Examining novel concepts of the pathophysiology of depression in the chronic psychosocial stress paradigm in tree shrews

How Do Glucocorticoids Influence Stress Responses? Integrating Permissive, Suppressive, Stimulatory, and Preparative Actions*

2000 • 6,211 citations

Requirement of Hippocampal Neurogenesis for the Behavioral Effects of Antidepressants

2003 • 4,175 citations

A Syndrome produced by Diverse Nocuous Agents

1936 • 3,733 citations

Chronic Antidepressant Treatment Increases Neurogenesis in Adult Rat Hippocampus

2000 • 3,047 citations

Functional neurogenesis in the adult hippocampus

2002 • 2,813 citations

Brain Corticosteroid Receptor Balance in Health and Disease*

1998 • 2,442 citations

Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis

1997 • 2,235 citations

Adult neurogenesis produces a large pool of new granule cells in the dentate gyrus

2001 • 1,554 citations

Assessing antidepressant activity in rodents: recent developments and future needs

2002 • 1,525 citations

Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation

1997 • 1,468 citations

Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress

1998 • 1,386 citations

Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus

2004 • 1,256 citations

The cellular neurobiology of depression

2001 • 1,169 citations

Untreated Depression and Hippocampal Volume Loss

2003 • 1,140 citations

Chronic mild stress-induced anhedonia: A realistic animal model of depression

1992 • 1,120 citations

Stress-induced changes in cerebral metabolites, hippocampal volume, and cell proliferation are prevented by antidepressant treatment with tianeptine

2001 • 1,082 citations

Adult brain neurogenesis and psychiatry: a novel theory of depression

2000 • 936 citations

Plasticity of the Hippocampus: Adaptation to Chronic Stress and Allostatic Load

2001 • 836 citations

Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation

1996 • 829 citations

Cell Proliferation in Adult Hippocampus is Decreased by Inescapable Stress: Reversal by Fluoxetine Treatment

2003 • 796 citations

Neurogenesis in the adult brain: death of a dogma

2000 • 796 citations

Reorganization of the morphology of hippocampal neurites and synapses after stress-induced damage correlates with behavioral improvement

2000 • 747 citations

Repeated restraint stress suppresses neurogenesis and induces biphasic PSA‐NCAM expression in the adult rat dentate gyrus

2003 • 641 citations

Neural plasticity to stress and antidepressant treatment

1999 • 638 citations

Enhancement of Hippocampal Neurogenesis by Lithium

2000 • 613 citations

Preclinical models: status of basic research in depression

2002 • 548 citations

Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain

2000 • 497 citations

Enhancing neuronal plasticity and cellular resilience to develop novel, improved therapeutics for Difficult-to-Treat depression

2003 • 494 citations

3D MRI studies of neuroanatomic changes in unipolar major depression: the role of stress and medical comorbidity

2000 • 486 citations

Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile Rhesus monkeys

2003 • 463 citations

Decreased Benzodiazepine Receptor Binding in Prefrontal Cortex in Combat-Related Posttraumatic Stress Disorder

2000 • 445 citations

Depressed new Neurons?—Adult hippocampal neurogenesis and a cellular plasticity hypothesis of major depression

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Contribution of life events to causation of psychiatric illness

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Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis

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Role of the dopaminergic system in depression

1992 • 346 citations

Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system.

1993 • 335 citations

Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible

2003 • 315 citations

Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus–pituitary–adrenal axis activation

2003 • 311 citations

Blockade of CRF1 or V1b receptors reverses stress-induced suppression of neurogenesis in a mouse model of depression

2003 • 309 citations

Neurogenesis in the Dentate Gyrus of the Rat Following Electroconvulsive Shock Seizures

2000 • 298 citations

Hippocampal Apoptosis in Major Depression Is a Minor Event and Absent from Subareas at Risk for Glucocorticoid Overexposure

2001 • 281 citations

Neither major depression nor glucocorticoid treatment affects the cellular integrity of the human hippocampus

2001 • 247 citations

Reduced cell proliferation in the dentate gyrusis not correlated with the development of learned helplessness

2003 • 222 citations

In vivo neurogenesis in the adult brain: regulation and functional implications

2000 • 212 citations

Antidepressant treatment with tianeptine reduces apoptosis in the hippocampal dentate gyrus and temporal cortex

2004 • 199 citations

Hibernation-induced structural changes in synaptic contacts between mossy fibres and hippocampal pyramidal neurons

1992 • 194 citations

Effects of estrogen in the CNS

1999 • 191 citations

Social stress in tree shrews

2002 • 185 citations

Electroconvulsive seizures increase hippocampal neurogenesis after chronic corticosterone treatment

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Hypothalamic-Pituitary-Adrenocortical Axis Changes in the Rat after Long-Term Treatment with the Reversible Monoamine Oxidase-A Inhibitor Moclobemide

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Elucidation of the neurobiology of depression: insights from a novel genetic animal model

2000 • 172 citations

Psychosocial stress in tree shrews: Clomipramine counteracts behavioral and endocrine changes

1996 • 168 citations

Chapter 21 The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia

1992 • 160 citations

Substance P receptor antagonist and clomipramine prevent stress-induced alterations in cerebral metabolites, cytogenesis in the dentate gyrus and hippocampal volume

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Effect of Chronic High-Dose Exogenous Cortisol on Hippocampal Neuronal Number in Aged Nonhuman Primates

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Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain

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Steroid hormones as mediators of neural plasticity

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Animal models of depression: are there any?

2003 • 126 citations

Identification of genes regulated by chronic psychosocial stress and antidepressant treatment in the hippocampus

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Effect of chronic psychosocial stress and long-term cortisol treatment on hippocampus-mediated memory and hippocampal volume: a pilot-study in tree shrews

2000 • 115 citations

Adult neurogenesis: a compensatory mechanism for neuronal damage

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Chronic psychosocial stress does not affect the number of pyramidal neurons in tree shrew hippocampus

1997 • 98 citations

5HT_1A‐receptors and behaviour under chronic stress: selective counteraction by testosterone

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Cortisol, 11-deoxycortisol, and ACTH concentrations after dexamethasone in depressed patients and healthy volunteers

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Perturbations in brain monoamine systems during stress

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Chronic psychosocial stress reduces the density of dopamine transporters

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Antidepressant medications, mood and male fertility

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Isolation and Pharmacological Characterization of Two Functional Splice Variants of Corticotropin‐Releasing Factor Type 2 Receptor from Tupaia belangeri

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Corticotropin‐releasing factor receptor type 1 from Tupaia belangeri

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Regulation of α2A-adrenoceptor expression by chronic stress in neurons of the brain stem

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Effects of Various Concentrations of Adrenocorticotrophic Hormone on Electrical Activity of Brain and on Sensitivity to Convulsion-Inducing Agents

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Cloning of glucocorticoid receptor and mineralocorticoid receptor cDNA and gene expression in the central nervous system of the tree shrew (Tupaia belangeri)

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Diazepam Has No Beneficial Effects on Stress-Induced Behavioural and Endocrine Changes in Male Tree Shrews

2000 • 51 citations

Male reproductive systems under chronic fluoxetine or trimipramine treatment

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Automated determination of clomipramine and its major metabolites in human and rat serum by high-performance liquid chromatography with on-line column-switching

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Chinning by maleTupaia belangeri: The effects of scent marks of conspecifics and of other species

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Non-competitive inhibition of clomipramineN-demethylation by fluvoxamine

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Chronic stress reduces fighting behavior of rats: The effect of antidepressants

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Clomipramine concentration as a predictor of delayed response: a naturalistic study

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High-Performance Liquid Chromatography of Clomipramine and Metabolites in Human Plasma and Urine

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