Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus

The Ki-67 protein: From the known and the unknown

2000 • 4,426 citations

Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

1999 • 3,805 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

Autoradiographic and histological evidence of postnatal hippocampal neurogenesis in rats

1965 • 3,461 citations

Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation

1996 • 3,079 citations

Running enhances neurogenesis, learning, and long-term potentiation in mice

1999 • 2,829 citations

Cardiovascular fitness, cortical plasticity, and aging

2004 • 1,612 citations

Astrocytes Give Rise to New Neurons in the Adult Mammalian Hippocampus

2001 • 1,475 citations

Neurogenesis in the Dentate Gyrus of the Adult Tree Shrew Is Regulated by Psychosocial Stress and NMDA Receptor Activation

1997 • 1,468 citations

Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo

2002 • 1,445 citations

Milestones of neuronal development in the adult hippocampus

2004 • 1,389 citations

Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease

2002 • 1,297 citations

Experience-Induced Neurogenesis in the Senescent Dentate Gyrus

1998 • 1,135 citations

Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus

1994 • 986 citations

Circulating Insulin-Like Growth Factor I Mediates Exercise-Induced Increases in the Number of New Neurons in the Adult Hippocampus

2001 • 976 citations

Early determination and long-term persistence of adult-generated new neurons in the hippocampus of mice

2002 • 954 citations

Doublecortin expression levels in adult brain reflect neurogenesis

2005 • 942 citations

Neuroplasticity in old age: Sustained fivefold induction of hippocampal neurogenesis by long‐term environmental enrichment

2002 • 881 citations

Peripheral Infusion of IGF-I Selectively Induces Neurogenesis in the Adult Rat Hippocampus

2000 • 838 citations

Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo

2004 • 816 citations

VEGF is necessary for exercise‐induced adult hippocampal neurogenesis

2003 • 801 citations

Circulating Insulin-Like Growth Factor I Mediates Effects of Exercise on the Brain

2000 • 734 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

Restoring production of hippocampal neurons in old age

1999 • 717 citations

Neural stem and progenitor cells in nestin‐GFP transgenic mice

2004 • 685 citations

Excitation-Neurogenesis Coupling in Adult Neural Stem/Progenitor Cells

2004 • 656 citations

Efficacy of doublecortin as a marker to analyse the absolute number anddendritic growth of newly generated neurons in the adult dentate gyrus

2004 • 638 citations

Genetic influence on neurogenesis in the dentate gyrus of adult mice

1997 • 624 citations

Subpopulations of proliferating cells of the adult hippocampus respond differently to physiologic neurogenic stimuli

2003 • 623 citations

Cell types, lineage, and architecture of the germinal zone in the adult dentate gyrus

2004 • 617 citations

Rapid extension of axons into the CA3 region by adult-generated granule cells

1999 • 597 citations

Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles

1999 • 561 citations

Exercise, experience and the aging brain1

2002 • 524 citations

Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain

2000 • 497 citations

Transient calretinin expression defines early postmitotic step of neuronal differentiation in adult hippocampal neurogenesis of mice

2003 • 475 citations

Why New Neurons? Possible Functions for Adult Hippocampal Neurogenesis

2002 • 464 citations

Subpopulation of nestin-expressing progenitor cells in the adult murine hippocampus shows electrophysiological and morphological characteristics of astrocytes

2003 • 460 citations

Mitotic neuroblasts in the 9-day-old and 11-month-old rodent hippocampus

1984 • 453 citations

Three‐dimensional counting: An accurate and direct method to estimate numbers of cells in sectioned material

1988 • 437 citations

Evidence that granule cells generated in the dentate gyrus of adult rats extend axonal projections

1988 • 429 citations

Neurogenesis in adulthood: a possible role in learning

1999 • 422 citations

Two Distinct Subpopulations of Nestin-Positive Cells in Adult Mouse Dentate Gyrus

2003 • 401 citations

Adrenal steroids and N-methyl-D-aspartate receptor activation regulate neurogenesis in the dentate gyrus of adult rats through a common pathway

1997 • 381 citations

Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis

2002 • 355 citations

Suppressed proliferation and apoptotic changes in the rat dentate gyrus after acute and chronic stress are reversible

2003 • 315 citations

Prominent decline of newborn cell proliferation, differentiation, and apoptosis in the aging dentate gyrus, in absence of an age-related hypothalamus–pituitary–adrenal axis activation

2003 • 311 citations

Physical exercise induces FGF-2 and its mRNA in the hippocampus

1997 • 286 citations

IGF-I has a direct proliferative effect in adult hippocampal progenitor cells

2003 • 272 citations

Spatial learning and physical activity contribute to the induction of fibroblast growth factor: neural substrates for increased cognition associated with exercise

1998 • 267 citations

Impact of age and caloric restriction on neurogenesis in the dentate gyrus of C57BL/6 mice

2003 • 260 citations

The exercise-induced expression of BDNF within the hippocampus varies across life-span

2005 • 256 citations

Adult hippocampal neurogenesis and voluntary running activity: Circadian and dose‐dependent effects

2004 • 231 citations

The murine Ki-67 cell proliferation antigen accumulates in the nucleolar and heterochromatic regions of interphase cells and at the periphery of the mitotic chromosomes in a process essential for cell cycle progression

1996 • 230 citations

Age‐dependent expression of glucocorticoid‐ and mineralocorticoid receptors on neural precursor cell populations in the adult murine hippocampus

2004 • 201 citations

Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor ε1 subunit

2003 • 137 citations

Adrenalectomy increases neurogenesis but not PSA‐NCAM expression in aged dentate gyrus

1999 • 135 citations

Age-dependence of the effect of treadmill exercise on cell proliferation in the dentate gyrus of rats

2003 • 110 citations

Marked species and age‐dependent differences in cell proliferation and neurogenesis in the hippocampus of wild‐living rodents

2004 • 107 citations

Complex Trait Analysis of the Hippocampus: Mapping and Biometric Analysis of Two Novel Gene Loci with Specific Effects on Hippocampal Structure in Mice

2001 • 98 citations

Running Wheel Accessibility Affects the Regional Electroencephalogram during Sleep in Mice

2005 • 69 citations

Voluntary wheel running modulates glutamate receptor subunit gene expression and stress hormone release in Lewis rats

2003 • 66 citations

Differential regulation of hippocampal progenitor proliferation by opioid receptor antagonists in running and non‐running spontaneously hypertensive rats

2004 • 65 citations