Aging Results in Reduced Epidermal Growth Factor Receptor Signaling, Diminished Olfactory Neurogenesis, and Deficits in Fine Olfactory Discrimination

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

Long-Distance Neuronal Migration in the Adult Mammalian Brain

1994 • 2,291 citations

Cellular Composition and Three-Dimensional Organization of the Subventricular Germinal Zone in the Adult Mammalian Brain

1997 • 1,878 citations

Restricted proliferation and migration of postnatally generated neurons derived from the forebrain subventricular zone

1993 • 1,799 citations

Autoradiographic and histological studies of postnatal neurogenesis. IV. Cell proliferation and migration in the anterior forebrain, with special reference to persisting neurogenesis in the olfactory bulb

1969 • 1,471 citations

Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells

1994 • 1,400 citations

Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration

2004 • 1,261 citations

Enhanced synaptic plasticity in newly generated granule cells of the adult hippocampus

2004 • 1,256 citations

Multipotent CNS Stem Cells Are Present in the Adult Mammalian Spinal Cord and Ventricular Neuroaxis

1996 • 1,209 citations

Autoradiographic and histological studies of postnatal neurogenesis. I. A longitudinal investigation of the kinetics, migration and transformation of cells incoorporating tritiated thymidine in neonate rats, with special reference to postnatal neurogenesis in some brain regions

1966 • 904 citations

Becoming a new neuron in the adult olfactory bulb

2003 • 787 citations

Sonic Hedgehog Is Required for Progenitor Cell Maintenance in Telencephalic Stem Cell Niches

2003 • 695 citations

Pregnancy-Stimulated Neurogenesis in the Adult Female Forebrain Mediated by Prolactin

2003 • 690 citations

Maturation and Death of Adult-Born Olfactory Bulb Granule Neurons: Role of Olfaction

2002 • 670 citations

Enriched Odor Exposure Increases the Number of Newborn Neurons in the Adult Olfactory Bulb and Improves Odor Memory

2002 • 662 citations

Erythropoietin Regulates theIn VitroandIn VivoProduction of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells

2001 • 649 citations

Regeneration of a germinal layer in the adult mammalian brain

1999 • 638 citations

Functional organization of olfactory system

1996 • 531 citations

Neural Stem Cell Detection, Characterization, and Age-Related Changes in the Subventricular Zone of Mice

2004 • 510 citations

Importance of newly generated neurons in the adult olfactory bulb for odor discrimination

2000 • 484 citations

Transforming Growth Factor-α Null and Senescent Mice Show Decreased Neural Progenitor Cell Proliferation in the Forebrain Subependyma

1997 • 442 citations

Centre–surround inhibition among olfactory bulb glomeruli

2003 • 423 citations

The generation, migration, and differentiation of olfactory neurons in the adult primate brain

2001 • 416 citations

A Systems Perspective on Early Olfactory Coding

1999 • 359 citations

Dendrodendritic Inhibition in the Olfactory Bulb Is Driven by NMDA Receptors

1998 • 349 citations

In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain

1998 • 304 citations

Electrophysiological Differentiation of New Neurons in the Olfactory Bulb

2003 • 300 citations

The Ciliary Neurotrophic Factor/Leukemia Inhibitory Factor/gp130 Receptor Complex Operates in the Maintenance of Mammalian Forebrain Neural Stem Cells

2001 • 291 citations

Functional Integration of Adult-Born Neurons

2002 • 289 citations

Isolation and Characterization of Neural Stem Cells from the Adult Human Olfactory Bulb

2000 • 223 citations

Adult Subventricular Zone Neuronal Precursors Continue to Proliferate and Migrate in the Absence of the Olfactory Bulb

1999 • 220 citations

Dendritic processing within olfactory bulb circuits

2003 • 213 citations

The neural cell adhesion molecule in synaptic plasticity and ageing

2000 • 209 citations

Proliferation in the Rat Olfactory Epithelium: Age-Dependent Changes

1997 • 202 citations

How simple is the organization of the olfactory glomerulus?: the heterogeneity of so-called periglomerular cells

1998 • 200 citations

Compartmental organization of the olfactory bulb glomerulus

1999 • 181 citations

Oxytocin and vasopressin release in the olfactory bulb of parturient ewes: changes with maternal experience and effects on acetylcholine, γ-aminobutyric acid, glutamate and noradrenaline release

1995 • 174 citations

Mechanisms of Lateral Inhibition in the Olfactory Bulb: Efficiency and Modulation of Spike-Evoked Calcium Influx into Granule Cells

2003 • 171 citations

Glycoprotein 130 Signaling RegulatesNotch1Expression and Activation in the Self-Renewal of Mammalian Forebrain Neural Stem Cells

2003 • 164 citations

The aging olfactory epithelium: Neurogenesis, response to damage, and odorant‐induced activity

1996 • 161 citations

Decline in Taste and Odor Discrimination Abilities with Age, and Relationship between Gustation and Olfaction

2000 • 146 citations

Lateral inhibition in the olfactory bulb and in olfaction

2002 • 132 citations

PSA‐NCAM: an important regulator of hippocampal plasticity

2000 • 131 citations

Recovery of emotional behaviour in neural cell adhesion molecule (NCAM) null mutant mice through transgenic expression of NCAM180

2000 • 127 citations

Peripheral Odor Coding in the Rat and Frog: Quality and Intensity Specification

2000 • 125 citations

Olfactory bulb core is a rich source of neural progenitor and stem cells in adult rodent and human

2003 • 124 citations

The effect of continuous intraventricular infusion of L1 and NCAM antibodies on spatial learning in rats

1996 • 120 citations

Proliferation, migration and differentiation of neuronal progenitor cells in the adult mouse subventricular zone surgically separated from its olfactory bulb

1998 • 109 citations

Epidermal growth factor-induced apoptosis in A431 cells can be reversed by reducing the tyrosine kinase activity.

1996 • 105 citations

Old-age deficits in the sense of smell as gauged by thresholds, magnitude matching, and odor identification.

1987 • 101 citations

Old-age deficits in the sense of smell as gauged by thresholds, magnitude matching, and odor identification.

1987 • 98 citations

Comparative study of aging in the mouse olfactory bulb

2002 • 94 citations

Age-Related Olfactory Dysfunction: Cellular and Molecular Characterization in the Rat

2003 • 71 citations

Importance of the CNGA4 channel gene for odor discrimination and adaptation in behaving mice

2003 • 70 citations

Odorant Threshold Following Methyl Bromide-Induced Lesions of the Olfactory Epithelium

1997 • 68 citations

Striatal TGF-α: postnatal developmental expression and evidence for a role in the proliferation of subependymal cells

1995 • 67 citations

Functional organization of the main olfactory bulb

1993 • 67 citations

GABA_BReceptors Inhibit Dendrodendritic Transmission in the Rat Olfactory Bulb

2003 • 61 citations

Ligand-induced, p38-dependent Apoptosis in Cells Expressing High Levels of Epidermal Growth Factor Receptor and ErbB-2

2004 • 61 citations

Comparison between epidermal growth factor, transforming growth factor-α and EGF receptor levels in regions of adult rat brain

1992 • 59 citations

An ultrastructural study of age-related changes in mouse olfactory epithelium

1999 • 53 citations

Proliferation Markers, Proliferating Cell Nuclear Antigen, Ki67, 5-Bromo-2′-Deoxyuridine, and Cyclin D1 in Mouse Olfactory Epithelium

2000 • 51 citations

Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues.

1996 • 47 citations

Linking oxidative stress and genetics of aging with p66Shc signaling and forkhead transcription factors.

2003 • 46 citations

Induction of EGF-Dependent Apoptosis by Vacuolar-Type H+-ATPase Inhibitors in A431 Cells Overexpressing the EGF Receptor

2002 • 40 citations

Odor Discrimination and Task Duration in Young and Older Adults

2000 • 29 citations

Enhancement by T-Type Ca²⁺Currents of Odor Sensitivity in Olfactory Receptor Cells

2001 • 29 citations

In vivo regulation of precursor cells in the subventricular zone of adult rat brain by thyroid hormone and retinoids

2000 • 25 citations

Up-regulation of α2β1 integrin cell-surface expresssion protects A431 cells from epidermal growth factor-induced apoptosis

2000 • 25 citations

Postnatal decrease in transforming growth factor α is associated with enlarged ventricles, deficient amygdaloid vasculature and performance deficits

2000 • 23 citations

Sequence-Specific Impairment of Memory Formation by NCAM Antisense Oligonucleotides

1999 • 18 citations

EGF mediates multiple signals: dependence on the conditions

2004 • 18 citations

Receptor Heterogeneity and its Effect on Sensitivity and Coding Range in Olfactory Sensory Neurons

2001 • 10 citations