Transgenic animal models of Alzheimer's disease and related disorders: histopathology, behavior and therapy

Neuropathological stageing of Alzheimer-related changes

1991 • 14,533 citations

Emotion Circuits in the Brain

2000 • 8,055 citations

Alzheimer's Disease: Genes, Proteins, and Therapy

2001 • 5,919 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Frontotemporal lobar degeneration

1998 • 4,937 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Alzheimer's Disease Is a Synaptic Failure

2002 • 4,102 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Triple-Transgenic Model of Alzheimer's Disease with Plaques and Tangles

2003 • 3,802 citations

β-Secretase Cleavage of Alzheimer's Amyloid Precursor Protein by the Transmembrane Aspartic Protease BACE

1999 • 3,692 citations

Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17

1998 • 3,377 citations

Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse

1999 • 3,112 citations

Phases of Aβ-deposition in the human brain and its relevance for the development of AD

2002 • 2,850 citations

Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus

1995 • 2,548 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Neurodegenerative Tauopathies

2001 • 2,276 citations

Staging of alzheimer's disease-related neurofibrillary changes

1995 • 2,187 citations

Alzheimer Disease in the US Population

2003 • 2,179 citations

Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease

2000 • 1,954 citations

Tau protein isoforms, phosphorylation and role in neurodegenerative disorders11These authors contributed equally to this work.

2000 • 1,878 citations

High-Level Neuronal Expression of Aβ_1–42in Wild-Type Human Amyloid Protein Precursor Transgenic Mice: Synaptotoxicity without Plaque Formation

2000 • 1,793 citations

Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

1998 • 1,786 citations

Dopaminergic Loss and Inclusion Body Formation in α-Synuclein Mice: Implications for Neurodegenerative Disorders

2000 • 1,729 citations

Enhanced Neurofibrillary Degeneration in Transgenic Mice Expressing Mutant Tau and APP

2001 • 1,543 citations

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

2000 • 1,498 citations

Formation of Neurofibrillary Tangles in P301L Tau Transgenic Mice Induced by Aβ42 Fibrils

2001 • 1,469 citations

Familial Alzheimer's Disease–Linked Presenilin 1 Variants Elevate Aβ1–42/1–40 Ratio In Vitro and In Vivo

1996 • 1,467 citations

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N–terminus of β–amyloid

1992 • 1,453 citations

Mutation in the tau gene in familial multiple system tauopathy with presenile dementia

1998 • 1,440 citations

Increased amyloid-β42(43) in brains of mice expressing mutant presenilin 1

1996 • 1,439 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

2000 • 1,433 citations

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

2001 • 1,418 citations

Neuronal loss correlates with but exceeds neurofibrillary tangles in Alzheimer's disease

1997 • 1,395 citations

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo

2003 • 1,393 citations

A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity

2001 • 1,382 citations

Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report

2003 • 1,373 citations

Tau is a candidate gene for chromosome 17 frontotemporal dementia

1998 • 1,344 citations

The Topographical and Neuroanatomical Distribution of Neurofibrillary Tangles and Neuritic Plaques in the Cerebral Cortex of Patients with Alzheimer's Disease

1991 • 1,344 citations

Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes

1998 • 1,336 citations

Subacute meningoencephalitis in a subset of patients with AD after Aβ42 immunization

2003 • 1,313 citations

Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein

2000 • 1,311 citations

Clinical and neuropathological criteria for frontotemporal dementia. The Lund and Manchester Groups.

1994 • 1,291 citations

Mutant presenilins of Alzheimer's disease increase production of 42-residue amyloid β-protein in both transfected cells and transgenic mice

1997 • 1,259 citations

An english translation of alzheimer's 1907 paper, “über eine eigenartige erkankung der hirnrinde”

1995 • 1,166 citations

GSK-3α regulates production of Alzheimer's disease amyloid-β peptides

2003 • 1,145 citations

Cloning and sequencing of the cDNA encoding a core protein of the paired helical filament of Alzheimer disease: identification as the microtubule-associated protein tau.

1988 • 1,073 citations

Accelerated Amyloid Deposition in the Brains of Transgenic Mice Coexpressing Mutant Presenilin 1 and Amyloid Precursor Proteins

1997 • 1,015 citations

Tangle and neuron numbers, but not amyloid load, predict cognitive status in Alzheimer’s disease

2003 • 1,006 citations

Skeletal and CNS Defects in Presenilin-1-Deficient Mice

1997 • 953 citations

Protofibrillar intermediates of amyloid beta-protein induce acute electrophysiological changes and progressive neurotoxicity in cortical neurons.

1999 • 917 citations

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

2000 • 896 citations

Tauopathy in Drosophila : Neurodegeneration Without Neurofibrillary Tangles

2001 • 894 citations

Functional gamma‐secretase inhibitors reduce beta‐amyloid peptide levels in brain

2001 • 876 citations

Reconstitution of γ-secretase activity

2003 • 868 citations

Immunization reverses memory deficits without reducing brain Aβ burden in Alzheimer's disease model

2002 • 858 citations

Alzheimer's disease: the cholesterol connection

2003 • 843 citations

β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: Implications for Alzheimer's therapy

1998 • 839 citations

Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease

1998 • 800 citations

Protofibrillar Intermediates of Amyloid β-Protein Induce Acute Electrophysiological Changes and Progressive Neurotoxicity in Cortical Neurons

1999 • 797 citations

aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

2002 • 795 citations

Antibodies against β-Amyloid Slow Cognitive Decline in Alzheimer's Disease

2003 • 783 citations

The biochemical pathway of neurofibrillary degeneration in aging and Alzheimer’s disease

1999 • 777 citations

A learning deficit related to age and β-amyloid plaques in a mouse model of Alzheimer's disease

2000 • 733 citations

The prolyl isomerase Pin1 restores the function of Alzheimer-associated phosphorylated tau protein

1999 • 701 citations

Abundant Tau Filaments and Nonapoptotic Neurodegeneration in Transgenic Mice Expressing Human P301S Tau Protein

2002 • 673 citations

Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms

2003 • 664 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Corticodentatonigral Degeneration With Neuronal Achromasia

1968 • 610 citations

TGF-β1 promotes microglial amyloid-β clearance and reduces plaque burden in transgenic mice

2001 • 576 citations

β-Amyloid peptides enhance α-synuclein accumulation and neuronal deficits in a transgenic mouse model linking Alzheimer's disease and Parkinson's disease

2001 • 573 citations

Age-Dependent Emergence and Progression of a Tauopathy in Transgenic Mice Overexpressing the Shortest Human Tau Isoform

1999 • 552 citations

Structural studies of tau protein and Alzheimer paired helical filaments show no evidence for beta-structure.

1994 • 544 citations

Cerebral amyloid angiopathy in the brains of patients with Alzheimer's disease

1996 • 532 citations

Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency

1999 • 517 citations

Aging renders the brain vulnerable to amyloid β-protein neurotoxicity

1998 • 513 citations

Aβ Deposition Is Associated with Neuropil Changes, but not with Overt Neuronal Loss in the Human Amyloid Precursor Protein V717F (PDAPP) Transgenic Mouse

1997 • 502 citations

Neocortical Neurofibrillary Tangles Correlate With Dementia Severity in Alzheimer's Disease

1995 • 488 citations

Cerebral Hemorrhage After Passive Anti-Aβ Immunotherapy

2002 • 485 citations

Human Wild-Type Tau Interacts with wingless Pathway Components and Produces Neurofibrillary Pathology in Drosophila

2002 • 474 citations

Tau Filament Formation in Transgenic Mice Expressing P301L Tau

2001 • 465 citations

Apolipoprotein E and Alzheimer's Disease

1996 • 457 citations

Validity and Reliability of the Preliminary NINDS Neuropathologic Criteria for Progressive Supranuclear Palsy and Related Disorders

1996 • 446 citations

The abnormal phosphorylation of tau protein at Ser-202 in Alzheimer disease recapitulates phosphorylation during development.

1993 • 439 citations

Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning

2002 • 437 citations

Somatodendritic localization and hyperphosphorylation of tau protein in transgenic mice expressing the longest human brain tau isoform.

1995 • 427 citations

Disruption of Axonal Transport and Neuronal Viability by Amyloid Precursor Protein Mutations in Drosophila

2001 • 424 citations

Reversible Memory Loss in a Mouse Transgenic Model of Alzheimer's Disease

2002 • 423 citations

Contribution by synaptic zinc to the gender-disparate plaque formation in human Swedish mutant APP transgenic mice

2002 • 419 citations

Frontotemporal Dementia and Corticobasal Degeneration in a Family with a P301S Mutation in Tau

1999 • 418 citations

Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease

1997 • 417 citations

Role of the prolyl isomerase Pin1 in protecting against age-dependent neurodegeneration

2003 • 416 citations

Heritability for Alzheimer's Disease: The Study of Dementia in Swedish Twins

1997 • 402 citations

Corticobasal degeneration: A clinical study of 36 cases

1994 • 400 citations

Neuronal overexpression of mutant amyloid precursor protein results in prominent deposition of cerebrovascular amyloid

1999 • 392 citations

Neprilysin Gene Transfer Reduces Human Amyloid Pathology in Transgenic Mice

2003 • 379 citations

Prominent Axonopathy in the Brain and Spinal Cord of Transgenic Mice Overexpressing Four-Repeat Human tau Protein

1999 • 378 citations

Apolipoprotein E fragments present in Alzheimer's disease brains induce neurofibrillary tangle-like intracellular inclusions in neurons

2001 • 366 citations

Assessment of normal and mutant human presenilin function in Caenorhabditis elegans

1996 • 360 citations

Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits.

1999 • 355 citations

Axonopathy and amyotrophy in mice transgenic for human four-repeat tau protein

2000 • 355 citations

Association of mitogen-activated protein kinase with the microtubule cytoskeleton.

1995 • 354 citations

Pick’s Disease

1974 • 349 citations

Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy

2003 • 345 citations

Expression of human apolipoprotein E reduces amyloid-β deposition in a mouse model of Alzheimer's disease

1999 • 342 citations

Accuracy of clinical criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome)

1996 • 341 citations

Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5

2000 • 336 citations

Mapping of a gene predisposing to early–onset Alzheimer's disease to chromosome 14q24.3

1992 • 332 citations

Association of Microglia with Amyloid Plaques in Brains of APP23 Transgenic Mice

1999 • 332 citations

Carboxyl-terminal-truncated apolipoprotein E4 causes Alzheimer's disease-like neurodegeneration and behavioral deficits in transgenic mice

2003 • 328 citations

Non-Fc-Mediated Mechanisms Are Involved in Clearance of Amyloid-βIn Vivoby Immunotherapy

2002 • 315 citations

Glycogen Synthase Kinase-3β Phosphorylates Protein Tau and Rescues the Axonopathy in the Central Nervous System of Human Four-repeat Tau Transgenic Mice

2000 • 313 citations

Causative and susceptibility genes for Alzheimer’s disease: a review

2003 • 310 citations

Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease.

2000 • 307 citations

Fine Structural Study of Neurofibrillary Changes in a Family with Amyotrophic Lateral Sclerosis

1984 • 300 citations

Molecular Interactions among Protein Phosphatase 2A, Tau, and Microtubules

1999 • 293 citations

Wnt signaling function in Alzheimer’s disease

2000 • 289 citations

Characterization of Pathology in Transgenic Mice Over-Expressing Human Genomic and cDNA Tau Transgenes

2000 • 282 citations

Generation of antibodies specific for β-amyloid by vaccination of patients with Alzheimer disease

2002 • 279 citations

Spontaneous Hemorrhagic Stroke in a Mouse Model of Cerebral Amyloid Angiopathy

2001 • 274 citations

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice

1999 • 273 citations

Tau‐positive dial Inclusions in Progressive Supranuclear Palsy, Corticobasal Degeneration and Pick's Disease

1999 • 269 citations

Nasal administration of amyloid-? peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease

2000 • 252 citations

Tau filament formation and associative memory deficit in aged mice expressing mutant (R406W) human tau

2002 • 251 citations

Selectively Reduced Expression of Synaptic Plasticity-Related Genes in Amyloid Precursor Protein + Presenilin-1 Transgenic Mice

2003 • 247 citations

Expression of Human Apolipoprotein E4 in Neurons Causes Hyperphosphorylation of Protein Tau in the Brains of Transgenic Mice

2000 • 238 citations

SOD1 mutation is assosiated with accumulation of neurofilaments in amyotrophic lateral scelaries

1996 • 237 citations

Neurodegeneration with Tau Accumulation in a Transgenic Mouse Expressing V337M Human Tau

2002 • 229 citations

Age-Related Amyloid β Deposition in Transgenic Mice Overexpressing Both Alzheimer Mutant Presenilin 1 and Amyloid β Precursor Protein Swedish Mutant Is Not Associated with Global Neuronal Loss

2000 • 227 citations

Subunit structure of paired helical filaments in Alzheimer's disease.

1985 • 224 citations

Accumulation of Phosphorylated Neurofilaments in Anterior Horn Motoneurons of Amyotrophic Lateral Sclerosis Patients

1988 • 223 citations

Phenotypic variation in hereditary frontotemporal dementia with tau mutations

1999 • 222 citations

Reduction of amyloid load and cerebral damage in transgenic mouse model of Alzheimer's disease by treatment with a β‐sheet breaker peptide

2002 • 216 citations

Interaction of Tau with the Neural Membrane Cortex Is Regulated by Phosphorylation at Sites That Are Modified in Paired Helical Filaments

2000 • 216 citations

Expression of tau protein in non-neuronal cells: microtubule binding and stabilization

1992 • 215 citations

A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L)

1999 • 214 citations

Conditioned taste aversion as a learning and memory paradigm

2001 • 209 citations

Glial Inclusions in CNS Degenerative Diseases

1996 • 209 citations

Neuronal overexpression of APPL, the Drosophila homologue of the amyloid precursor protein (APP), disrupts axonal transport

1999 • 204 citations

TauGene Mutation G389R Causes a Tauopathy with Abundant Pick Body-like Inclusions and Axonal Deposits

1999 • 204 citations

Reduced Protein Phosphatase 2A Activity Induces Hyperphosphorylation and Altered Compartmentalization of Tau in Transgenic Mice

2001 • 199 citations

Sporadic and Familial Cerebral Amyloid Angiopathies

2002 • 196 citations

A Critical Analysis of New Molecular Targets and Strategies for Drug Developments in Alzheimers Disease

2003 • 189 citations

Tau gene mutation in familial progressive subcortical gliosis

1999 • 189 citations

Rapidly progressive autosomal dominant parkinsonism and dementia with pallido‐ponto‐nigral degeneration

1992 • 184 citations

Image reconstruction of the Alzheimer paired helical filament.

1985 • 184 citations

Tau Pathology in a Family with Dementia and a P301L Mutation in Tau

1999 • 181 citations

Autosomal dominant dementia with widespread neurofibrillary tangles

1997 • 179 citations

Nerve inflammation halts trial for Alzheimer's drug

2002 • 176 citations

β-Amyloid Induces Paired Helical Filament-like Tau Filaments in Tissue Culture

2003 • 172 citations

Nonoverlapping but synergetic tau and APP pathologies in sporadic Alzheimer’s disease

2002 • 171 citations

Mutant Human Presenilin 1 Protects presenilin 1 Null Mouse against Embryonic Lethality and Elevates Aβ1–42/43 Expression

1998 • 169 citations

Age-Dependent Induction of Congophilic Neurofibrillary Tau Inclusions in Tau Transgenic Mice

2001 • 166 citations

Cholinergic Changes in the APP23 Transgenic Mouse Model of Cerebral Amyloidosis

2002 • 161 citations

Tau and transgenic animal models

2001 • 160 citations

Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei

2001 • 160 citations

The molecular and genetic basis of AD: The end of the beginning

2000 • 157 citations

Transgenic Drosophila expressing human amyloid precursor protein show γ-secretase activity and a blistered-wing phenotype

1998 • 155 citations

Activation of the ERK and JNK Signaling Pathways Caused by Neuron-Specific Inhibition of PP2A in Transgenic Mice

2003 • 150 citations

Transgenic Mouse Model of Tauopathies with Glial Pathology and Nervous System Degeneration

2002 • 144 citations

The pool of map kinase associated with microtubules is small but constitutively active.

1996 • 142 citations

Analysis of Protein Domain Families inCaenorhabditis elegans

1997 • 133 citations

Overexpression ofhAPPsweImpairs Rewarded Alternation and Contextual Fear Conditioning in a Transgenic Mouse Model of Alzheimer's Disease

2002 • 133 citations

Formation of Filamentous Tau Aggregations in Transgenic Mice Expressing V337M Human Tau

2001 • 132 citations

Impaired fear conditioning in Alzheimer’s disease

2002 • 126 citations

Expression of human β‐secretase in the mouse brain increases the steady‐state level of β‐amyloid

2002 • 120 citations

Stereologic analysis of neurofibrillary tangle formation in prefrontal cortex area 9 in aging and Alzheimer’s disease

2003 • 118 citations

Quantitative neuropathologic analysis of Pick's disease cases: cortical distribution of Pick bodies and coexistence with Alzheimer's disease

1994 • 117 citations

Familial presenile dementia with psychosis associated with cortical neurofibrillary tangles and degeneration of the amygdala

1992 • 117 citations

Presenilin is required for proper morphology and function of neurons in C. elegans

2000 • 106 citations

Oligodendroglial tau filament formation in transgenic mice expressing G272V tau

2001 • 103 citations

Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes

2003 • 99 citations

Axonopathy, tau abnormalities, and dyskinesia, but no neurofibrillary tangles in p25‐transgenic mice

2002 • 99 citations

Somatodendritic localization of phosphorylated tau in neonatal and adult rat cerebral cortex

1997 • 95 citations

Frontotemporal dementia: Neuropil spheroids and presynaptic terminal degeneration

1998 • 95 citations

Mapping of a disease locus for familial rapidly progressive frontotemporal dementia to chromosome 17q12-21

1997 • 92 citations

Accelerated extinction of conditioned taste aversion in P301L tau transgenic mice

2004 • 91 citations

Proline‐directed phosphorylation and isomerization in mitotic regulation and in Alzheimer's Disease

2003 • 88 citations

Dosing in phase II trial of Alzheimer's vaccine suspended

2002 • 87 citations

The structure of divalent cation-induced aggregates of PIP2 and their alteration by gelsolin and tau

1997 • 86 citations

Localization of frontotemporal dementia with parkinsonism in an Australian kindred to chromosome 17q21–22

1997 • 82 citations

A mutation in the microtubule-associated protein tau in pallido-nigro-luysian degeneration

1999 • 82 citations

Coexpression of Human cdk5 and Its Activator p35 with Human Protein Tau in Neurons in Brain of Triple Transgenic Mice

2001 • 80 citations

Glial Cells Under Physiologic and Pathologic Conditions

2002 • 80 citations

Gustatory and olfactory dysfunction in dementia: Not specific to Alzheimer's disease

1990 • 79 citations

Human tau filaments induce microtubule and synapse loss in an in vivo model of neurofibrillary degenerative disease

2000 • 77 citations

Tau complexes with phospholipase C-γ in situ

1998 • 76 citations

Stabilization of the cyclin‐dependent kinase 5 activator, p35, by paclitaxel decreases β‐amyloid toxicity in cortical neurons

2003 • 73 citations

Structure and elasticity of microtubule-associated protein tau

1988 • 72 citations

Calpain inhibitors

2002 • 71 citations

A clinical pathological comparison of three families with frontotemporal dementia and identical mutations in the tau gene (P301L)

1999 • 68 citations

Alzheimer's and Parkinson's disease – overlapping or synergistic pathologies?

2002 • 62 citations

Extensive Dendritic Sprouting Induced by Close Axotomy of Central Neurons in the Lamprey

1983 • 60 citations

Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer’s disease?

2000 • 60 citations

Identification of 3′UTR region implicated in tau mRNA stabilization in neuronal cells

1999 • 58 citations

Staging of Neurofibrillary Degeneration Caused by Human Tau Overexpression in a Unique Cellular Model of Human Tauopathy

2001 • 57 citations

Prevention and Reduction of AD‐type Pathology in PDAPP Mice Immunized with Aβ_1–42

2000 • 53 citations

The generation and characterization of potentially therapeutic Aβ antibodies in mice: differences according to strain and immunization protocol

2002 • 50 citations

Neurofibrillary Degeneration Can Be Arrested in an In Vivo Cellular Model of Human Tauopathy by Application of a Compound Which Inhibits Tau Filament Formation In Vitro

2002 • 38 citations

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1991 • 30 citations

Transgenic and Knockout Models of PP2A

2003 • 30 citations

Role of apoE/Aβ interactions in Alzheimer's disease: insights from transgenic mouse models

2002 • 30 citations

[Taste impairment in Alzheimer's disease].

2001 • 27 citations

Transgenic Mouse Models with Tau Pathology to Test Therapeutic Agents for Alzheimers Disease

2002 • 10 citations