Nature, nurture and neurology: gene–environment interactions in neurodegenerative disease

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 • 7,941 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Parkinson's Disease

2003 • 5,061 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease

1991 • 4,533 citations

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

1995 • 3,985 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Chronic systemic pesticide exposure reproduces features of Parkinson's disease

2000 • 3,559 citations

More hippocampal neurons in adult mice living in an enriched environment

1997 • 3,476 citations

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. The Huntington's Disease Collaborative Research Group.

1993 • 3,080 citations

Exon 1 of the HD Gene with an Expanded CAG Repeat Is Sufficient to Cause a Progressive Neurological Phenotype in Transgenic Mice

1996 • 3,012 citations

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

1997 • 2,762 citations

Neural consequences of enviromental enrichment

2000 • 2,376 citations

A polymorphic DNA marker genetically linked to Huntington's disease

1983 • 2,329 citations

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

1997 • 2,184 citations

Alzheimer Disease in the US Population

2003 • 2,179 citations

Familial Alzheimer's disease in kindreds with missense mutations in a gene on chromosome 1 related to the Alzheimer's disease type 3 gene

1995 • 2,028 citations

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1994 • 1,813 citations

Mutation of the β-amyloid precursor protein in familial Alzheimer's disease increases β-protein production

1992 • 1,723 citations

Physical Activity and Risk of Cognitive Impairment and Dementia in Elderly Persons

2001 • 1,518 citations

Influence of Education and Occupation on the Incidence of Alzheimer's Disease

1994 • 1,373 citations

Uber eine eigenartige Erkrankung der Hirnrinde

1907 • 1,332 citations

Participation in Cognitively Stimulating Activities and Risk of Incident Alzheimer Disease

2002 • 1,297 citations

Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

2001 • 1,293 citations

Consumption of Fish and n-3 Fatty Acids and Risk of Incident Alzheimer Disease

2003 • 1,129 citations

The relationship between trinucleotide (CAG) repeat length and clinical features of Huntington's disease

1993 • 1,084 citations

Paired Helical Filaments in Electron Microscopy of Alzheimer's Disease

1963 • 956 citations

Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 • 941 citations

Aph-1, Pen-2, and Nicastrin with Presenilin Generate an Active γ-Secretase Complex

2003 • 933 citations

Characterization of Progressive Motor Deficits in Mice Transgenic for the Human Huntington’s Disease Mutation

1999 • 933 citations

Impaired synaptic plasticity and learning in aged amyloid precursor protein transgenic mice

1999 • 918 citations

Parkinson Disease in Twins<SUBTITLE>An Etiologic Study</SUBTITLE>

1999 • 861 citations

Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice

2005 • 859 citations

Anterograde transport of brain-derived neurotrophic factor and its role in the brain

1997 • 853 citations

Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague–dawley rats in vivo

2004 • 816 citations

A Familial Alzheimer's Disease Locus on Chromosome 1

1995 • 810 citations

Influence of leisure activity on the incidence of Alzheimer’s Disease

2001 • 793 citations

Chemical and Anatomical Plasticity of Brain

1964 • 757 citations

Venezuelan kindreds reveal that genetic and environmental factors modulate Huntington's disease age of onset

2004 • 737 citations

Environmental enrichment inhibits spontaneous apoptosis, prevents seizures and is neuroprotective

1999 • 733 citations

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

2000 • 722 citations

Vascular risk factors for Alzheimer’s disease:

2000 • 657 citations

Frontotemporal dementia and parkinsonism linked to chromosome 17: A consensus conference

1997 • 626 citations

Functional significance of adult neurogenesis

2004 • 625 citations

Effects of environmental enrichment on gene expression in the brain

2000 • 602 citations

Synergistic Effects of Traumatic Head Injury and Apolipoprotein-epsilon4 in Patients With Alzheimer's Disease

1995 • 588 citations

Head Trauma as a Risk Factor for Alzheimer's Disease: A Collaborative Re-Analysis of Case-Control Studies

1991 • 582 citations

Exercise, experience and the aging brain1

2002 • 524 citations

Increased cell proliferation and neurogenesis in the adult human Huntington's disease brain

2003 • 518 citations

The pattern of neurodegeneration in Huntington's disease: a comparative study of cannabinoid, dopamine, adenosine and GABAA receptor alterations in the human basal ganglia in Huntington's disease

2000 • 517 citations

E<scp>PIDEMIOLOGY OF</scp>N<scp>EURODEGENERATION</scp>

2003 • 513 citations

Altered brain neurotransmitter receptors in transgenic mice expressing a portion of an abnormal human Huntington disease gene

1998 • 509 citations

Neurogenesis in Adult Mammals: Some Progress and Problems

2002 • 509 citations

Delaying the onset of Huntington's in mice

2000 • 507 citations

Post-Natal Origin of Microneurones in the Rat Brain

1965 • 468 citations

Caloric Intake and the Risk of Alzheimer Disease

2002 • 464 citations

Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17: A New Group of Tauopathies

1998 • 459 citations

Genetic evidence for a novel familial Alzheimer's disease locus on chromosome 14

1992 • 458 citations

The structure of the presenilin 1 (S182) gene and identification of six novel mutations in early onset AD families

1995 • 453 citations

Cognitive activity and incident AD in a population-based sample of older persons

2002 • 450 citations

Patients with Alzheimer's disease have reduced activities in midlife compared with healthy control-group members

2001 • 431 citations

Dietary factors and Alzheimer's disease

2004 • 430 citations

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

2003 • 417 citations

Abnormal Synaptic Plasticity and Impaired Spatial Cognition in Mice Transgenic for Exon 1 of the Human Huntington's Disease Mutation

2000 • 406 citations

Dietary Restriction Increases the Number of Newly Generated Neural Cells, and Induces BDNF Expression, in the Dentate Gyrus of Rats

2000 • 396 citations

Alzheimer's disease and Aβ toxicity: from top to bottom

2001 • 396 citations

Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment

1992 • 386 citations

Selective Discrimination Learning Impairments in Mice Expressing the Human Huntington's Disease Mutation

1999 • 383 citations

Cigarette smoking and protection from Parkinson's disease

1995 • 372 citations

Dysregulation of gene expression in the R6/2 model of polyglutamine disease: parallel changes in muscle and brain

2002 • 365 citations

Environmental Enrichment Rescues Protein Deficits in a Mouse Model of Huntington's Disease, Indicating a Possible Disease Mechanism

2004 • 363 citations

Transient and Progressive Electrophysiological Alterations in the Corticostriatal Pathway in a Mouse Model of Huntington's Disease

2003 • 353 citations

Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease

1999 • 348 citations

Endogenously Produced Neurotrophins Regulate Survival and Differentiation of Cortical Progenitors via Distinct Signaling Pathways

2003 • 338 citations

Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis

2002 • 335 citations

Environmental Enrichment Modifies the PKA-Dependence of Hippocampal LTP and Improves Hippocampus-Dependent Memory

2001 • 334 citations

Environmental enrichment slows disease progression in R6/2 Huntington's disease mice

2002 • 333 citations

Brain-derived neurotrophic factor in Huntington disease

2000 • 326 citations

A meta-analysis of Parkinson's disease and exposure to pesticides.

2000 • 320 citations

Changes in Cortical and Striatal Neurons Predict Behavioral and Electrophysiological Abnormalities in a Transgenic Murine Model of Huntington's Disease

2001 • 294 citations

Enrichment enhances spatial memory and increases synaptophysin levels in aged female mice

2003 • 293 citations

Benefits of cognitive-motor intervention in MCI and mild to moderate Alzheimer disease

2004 • 291 citations

NMDA receptor function in mouse models of Huntington disease

2001 • 277 citations

Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running.

2003 • 269 citations

Acceleration of Visual System Development by Environmental Enrichment

2004 • 265 citations

Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year

1999 • 257 citations

Huntington's disease

2002 • 245 citations

Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease

1997 • 245 citations

Cognitive reserve: Implications for diagnosis and prevention of Alzheimer’s disease

2004 • 238 citations

Environmental enrichment improves cognition in aged Alzheimer's transgenic mice despite stable β-amyloid deposition

2004 • 231 citations

Environmental Enrichment Exacerbates Amyloid Plaque Formation in a Transgenic Mouse Model of Alzheimer Disease

2003 • 214 citations

Environmental enrichment reverses cognitive and molecular deficits induced by developmental lead exposure

2002 • 206 citations

Neurofibrillary tangles of Alzheimer's disease: an immunohistochemical study.

1985 • 201 citations

Dendritic spine pathology and deficits in experience‐dependent dendritic plasticity in R6/1 Huntington's disease transgenic mice

2004 • 189 citations

Environmental enrichment: Effects on spatial memory and hippocampal CREB immunoreactivity

2001 • 188 citations

The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: Neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis

2001 • 187 citations

Environmental enrichment results in cortical and subcortical changes in levels of synaptophysin and PSD-95 proteins

2004 • 185 citations

Effects of Environmental Enrichment on Spatial Memory and Neurochemistry in Middle-Aged Mice

2003 • 161 citations

Enriched environment and acceleration of visual system development

2004 • 159 citations

Decreased hippocampal cell proliferation in R6/1 Huntington’s mice

2004 • 150 citations

Pharmacotherapeutic approaches to the treatment of Alzheimer's disease

2004 • 146 citations

ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory

2003 • 145 citations

Alzheimer’s disease: Insights from epidemiology

2001 • 142 citations

Increased huntingtin protein length reduces the number of polyglutamine-induced gene expression changes in mouse models of Huntington's disease

2002 • 142 citations

Gene–Diet Interactions in Brain Aging and Neurodegenerative Disorders

2003 • 138 citations

Delayed onset of huntington′s disease in mice in an enriched environment correlates with delayed loss of cannabinoid CB1 receptors

2003 • 138 citations

Enhancement of neurogenesis by running wheel exercises is suppressed in mice lacking NMDA receptor ε1 subunit

2003 • 137 citations

Evidence for the GluR6 gene associated with younger onset age of Huntington’s disease

1999 • 137 citations

Head injury as a risk factor in Alzheimer's disease

1995 • 135 citations

Striatal Transplantation in a Transgenic Mouse Model of Huntington's Disease

1998 • 122 citations

N-Acetylaspartate and DARPP-32 levels decrease in the corpus striatum of Huntingtonʼs disease mice

2000 • 120 citations

Essential fatty acids given from conception prevent topographies of motor deficit in a transgenic model of Huntington’s disease

2002 • 120 citations

Huntingtin in health and disease

2003 • 117 citations

Deficits in Experience-Dependent Cortical Plasticity and Sensory-Discrimination Learning in Presymptomatic Huntington's Disease Mice

2005 • 115 citations

Age of onset in Huntington disease: sex specific influence of apolipoprotein E genotype and normal CAG repeat length.

1999 • 115 citations

Neuronal Structure is Altered by Amyloid Plaques

2004 • 111 citations

Upregulation of the immediate early gene arc in the brains of rats exposed to environmental enrichment: implications for molecular plasticity

2001 • 109 citations

Environmental enrichment prevents effects of dark-rearing in the rat visual cortex

2004 • 103 citations

Familial influence on age of onset among siblings with Huntington disease*

2001 • 98 citations

Genetic contributions to Parkinson's disease

2004 • 90 citations

Differential clinical and motor control function in a pair of monozygotic twins with Huntington's disease

1999 • 90 citations

“Impoverished” rats weigh more than “Enriched” rats because they eat more

1977 • 89 citations

Complexity of sensory environment drives the expression of candidate-plasticity gene, nerve growth factor induced-A

2002 • 88 citations

Environmental, pharmacological, and genetic modulation of the HD phenotype in transgenic mice

2004 • 85 citations

Huntington's Disease (3rd edn)

2003 • 84 citations

Tocopherol (Vitamin E) in Alzheimer???s Disease and Other Neurodegenerative Disorders

2004 • 82 citations

Gene Expression Profiling in the Intact and Injured Brain Following Environmental Enrichment

2004 • 75 citations

Transgenic models of Huntington'sdisease

1999 • 73 citations

Enriched environment influences brain-derived neurotrophic factor levels in rat forebrain after focal stroke

2001 • 69 citations

The Role of Cholesterol and Statins in Alzheimer's Disease

2003 • 66 citations

Age-Environment and Gene-Environment Interactions in the Pathogenesis of Parkinson's Disease

2002 • 64 citations

Anterior cingulate cortical transplantation in transgenic Huntington’s disease mice

2001 • 62 citations

Genetic and environmental factors in the pathogenesis of Huntington’s disease

2004 • 59 citations

Regular Exercise: An Effective Means to Reduce Oxidative Stress in Old Rats

2004 • 55 citations

Parkinson's disease, pesticides and individual vulnerability

2004 • 50 citations

Caffeinated clues from epidemiology of Parkinson’s disease

2003 • 48 citations

Mouse models of Alzheimer's disease: The long and filamentous road

2003 • 46 citations

Remotivation Therapy and Huntingtonʼs Disease

2001 • 45 citations

Impaired learning-dependent cortical plasticity in Huntington's disease transgenic mice

2004 • 42 citations

Pharmacotherapeutic approaches to the prevention of Alzheimer's disease

2004 • 39 citations

Molecular mediators, environmental modulators and experience-dependent synaptic dysfunction in Huntington's disease.

2004 • 24 citations

Huntington's disease: which drugs might help patients?

2004 • 22 citations