A Mutation in the Tyrosine Kinase Domain of the Insulin Receptor Associated with Insulin Resistance in an Obese Woman*

A general method ofin vitropreparation and specific mutagenesis of DNA fragments: study of protein and DNA interactions

1988 • 2,410 citations

Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes

1985 • 2,257 citations

Insulin-like growth factor I receptor primary structure: comparison with insulin receptor suggests structural determinants that define functional specificity.

1986 • 1,866 citations

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

1988 • 1,582 citations

The human insulin receptor cDNA: The structural basis for hormone-activated transmembrane signalling

1985 • 1,485 citations

Replacement of insulin receptor tyrosine residues 1162 and 1163 compromises insulin-stimulated kinase activity and uptake of 2-deoxyglucose

1986 • 1,100 citations

Simple and Rapid Preparation of Samples for PCR

1989 • 596 citations

A cascade of tyrosine autophosphorylation in the beta-subunit activates the phosphotransferase of the insulin receptor.

1988 • 467 citations

Two Mutant Alleles of the Insulin Receptor Gene in a Patient with Extreme Insulin Resistance

1988 • 308 citations

Hyperandrogenism, insulin resistance, and acanthosis nigricans syndrome: A common endocrinopathy with distinct pathophysiologic features

1983 • 291 citations

Insulin-Resistant Diabetes Due to a Point Mutation That Prevents Insulin Proreceptor Processing

1988 • 253 citations

Primary Structure of a Putative Receptor for a Ligand of the Insulin Family

1989 • 224 citations

Human Diabetes Associated with a Mutation in the Tyrosine Kinase Domain of the Insulin Receptor

1989 • 192 citations

Five mutant alleles of the insulin receptor gene in patients with genetic forms of insulin resistance.

1990 • 183 citations

Acanthosis nigricans in Obese Women with Hyperandrogenism: Characterization of an Insulin-Resistant State Distinct from the Type A and B Syndromes

1985 • 156 citations

A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes.

1989 • 155 citations

A nonsense mutation causing decreased levels of insulin receptor mRNA: detection by a simplified technique for direct sequencing of genomic DNA amplified by the polymerase chain reaction.

1990 • 155 citations

Detection of an Alteration in the Insulin-Receptor Gene in a Patient with Insulin Resistance, Acanthosis Nigricans, and the Polycystic Ovary Syndrome (Type A Insulin Resistance)

1988 • 153 citations

Insulin Resistance Associated with Androgen Excess in Women with Autoantibodies to the Insulin Receptor

1982 • 146 citations

Identification of the insulin receptor tyrosine residues undergoing insulin-stimulated phosphorylation in intact rat hepatoma cells.

1988 • 145 citations

Substrate Phosphorylation Catalyzed by the Insulin Receptor Tyrosine Kinase

1989 • 132 citations

Human Diabetes Associated with a Deletion of the Tyrosine Kinase Domain of the Insulin Receptor

1989 • 129 citations

Isolation of a Drosophila genomic sequence homologous to the kinase domain of the human insulin receptor and detection of the phosphorylated Drosophila receptor with an anti-peptide antibody.

1986 • 123 citations

The Rat Insulin Receptor: Primary Structure and Conservation of Tissue-Specific Alternative Messenger RNA Splicing

1990 • 119 citations

A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance.

1990 • 118 citations

Human Insulin-Receptor Gene: Partial Sequence and Amplification of Exons by Polymerase Chain Reaction

1990 • 115 citations

Insulin Resistance, Acanthosis Nigricans, and Normal Insulin Receptors in a Young Woman: Evidence for a Postreceptor Defect

1978 • 94 citations

Insulin-resistant diabetes associated with partial deletion of insulin-receptor gene

1990 • 73 citations

Primary amenorrhea associated with hirsutism, acanthosis nigricans, dermoid cysts of the ovaries and a new type of insulin resistance

1978 • 69 citations

Normal Insulin-Receptor cDNA Sequence in Pima Indians With NIDDM

1989 • 69 citations

Tyrosine Kinase Activity of the Insulin Receptor of Patients with Type A Extreme Insulin Resistance: Studies with Circulating Mononuclear Cells and Cultured Lymphocytes

1984 • 60 citations

Functional Properties of a Naturally Occurring Trp¹²⁰⁰→ Ser¹²⁰⁰Mutation of the Insulin Receptor

1990 • 48 citations

Insulin resistance by unprocessed insulin proreceptors point mutation at the cleavage site

1988 • 46 citations

The Amino Acid Sequence of the Insulin Receptor Is Normal in an Insulin-Resistant Pima Indian*

1990 • 43 citations

Acanthosis nigricans and obesity: Acquired and intrinsic defects in insulin action

1986 • 41 citations

Immunological Abnormalities in Insulin Receptors on Cultured EBV-Transformed Lymphocytes From Insulin-Resistant Patient With Leprechaunism

1988 • 23 citations

Tyrosine kinase activity of insulin receptors from an insulin-resistant patient with leprechaunism

1987 • 15 citations