Nitric oxide in cancer and chemoprevention

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

p53 Mutations in Human Cancers

1991 • 8,133 citations

Inflammation and cancer: back to Virchow?

2001 • 7,259 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1999 • 3,529 citations

Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation

2001 • 3,295 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

Oxyradicals and DNA damage

2000 • 1,876 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

Ulcerative Colitis and Colorectal Cancer

1990 • 1,755 citations

Therapeutic potential of inhibition of the NF-κB pathway in the treatment of inflammation and cancer

2001 • 1,548 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Reactive oxygen and nitrogen intermediates in the relationship between mammalian hosts and microbial pathogens

2000 • 1,429 citations

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

1996 • 1,311 citations

An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.

1990 • 1,209 citations

Nitric oxide production contributes to the angiogenic properties of vascular endothelial growth factor in human endothelial cells.

1997 • 1,162 citations

A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization.

1996 • 1,146 citations

Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

2000 • 1,087 citations

Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide.

1993 • 1,077 citations

Survival and Causes of Death in Cirrhotic and in Noncirrhotic Patients with Primary Hemochromatosis

1985 • 1,069 citations

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

1994 • 1,065 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

Nitric oxide mediates angiogenesis in vivo and endothelial cell growth and migration in vitro promoted by substance P.

1994 • 858 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Suppression of Apoptosis by Nitric Oxide via Inhibition of Interleukin-1β–converting Enzyme (ICE)-like and Cysteine Protease Protein (CPP)-32–like Proteases

1997 • 809 citations

Molecular mechanisms and therapeutic strategies related to nitric oxide

1995 • 791 citations

Roles of nitric oxide in tumor growth.

1995 • 791 citations

Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.

1993 • 785 citations

RNA interference—2001

2001 • 698 citations

Role of redox potential and reactive oxygen species in stress signaling

1999 • 695 citations

Nitric oxide synthase activity in human breast cancer

1995 • 637 citations

A hypoxia-responsive element mediates a novel pathway of activation of the inducible nitric oxide synthase promoter.

1995 • 630 citations

Nitric oxide as a mediator of nonadrenergic noncholinergic neurotransmission

1992 • 599 citations

Increased expression of inducible nitric oxide synthase and cyclooxygenase-2 in Barrett's esophagus and associated adenocarcinomas.

1998 • 595 citations

Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease

1996 • 588 citations

The chemistry of DNA damage from nitric oxide and peroxynitrite

1999 • 547 citations

Nitric Oxide as a Bioregulator of Apoptosis

2001 • 535 citations

Chronic immune activation and inflammation as the cause of malignancy

2001 • 534 citations

Oxidative stress and cell cycle checkpoint function11Both Drs. Paules and Kaufmann received their doctoral degrees in Experimental Pathology from the University of North Carolina at Chapel Hill School of Medicine (in 1984 and 1979, respectively).

2000 • 516 citations

Ulcerative colitis and Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis.

1994 • 512 citations

Inducible nitric oxide synthase, nitrotyrosine, and apoptosis in Helicobacter pylori gastritis: effect of antibiotics and antioxidants.

1996 • 494 citations

Molecular cloning and characterization of human endothelial nitric oxide synthase

1992 • 494 citations

Aflatoxin B1 induces the transversion of G-->T in codon 249 of the p53 tumor suppressor gene in human hepatocytes.

1993 • 482 citations

Endothelium-Dependent and -Independent Vasodilation Involving Cyclic GMP: Relaxation Induced by Nitric Oxide, Carbon Monoxide and Light

1991 • 476 citations

Increased p53 mutation load in noncancerous colon tissue from ulcerative colitis: a cancer-prone chronic inflammatory disease.

2000 • 475 citations

Frequent nitric oxide synthase-2 expression in human colon adenomas: implication for tumor angiogenesis and colon cancer progression.

1998 • 471 citations

Cellular regulation of endothelial nitric oxide synthase

2001 • 468 citations

Nitric oxide-induced p53 accumulation and regulation of inducible nitric oxide synthase expression by wild-type p53.

1996 • 455 citations

Nitric oxide synthase activity in human gynecological cancer.

1994 • 428 citations

Role of Nitric Oxide in Angiogenesis and Tumor Progression in Head and Neck Cancer

1998 • 427 citations

Inflammation and Oxidative Stress in Carcinogenesis

1993 • 419 citations

Diffusion of Nitric Oxide in the Aorta Wall Monitored in Situ by Porphyrinic Microsensors

1993 • 418 citations

Increased expression and cellular localization of inducible nitric oxide synthase and cyclooxygenase 2 in Helicobacter pylori gastritis☆, ☆☆

1999 • 408 citations

Molecular cloning, structure, and chromosomal localization of the human inducible nitric oxide synthase gene.

1994 • 403 citations

The regulatory role of nitric oxide in apoptosis

2001 • 384 citations

Expression of nitric oxide synthase in human central nervous system tumors.

1995 • 370 citations

Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.

1999 • 332 citations

Phosphorylation and subcellular translocation of endothelial nitric oxide synthase.

1993 • 329 citations

Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.

1995 • 326 citations

Molecular biology of nitric oxide synthases.

1998 • 326 citations

Hepatitis B virus X protein and p53 tumor suppressor interactions in the modulation of apoptosis

1997 • 322 citations

Human neutrophils and mononuclear cells inhibit platelet aggregation by releasing a nitric oxide-like factor.

1989 • 311 citations

Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte.

1993 • 302 citations

Chemical biology of nitric oxide: Regulation and protective and toxic mechanisms

1996 • 288 citations

Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

1996 • 284 citations

Geographic Variation of p53 Mutational Profile in Nonmalignant Human Liver

1994 • 282 citations

Role of nitric oxide in tumour progression: lessons from human tumours.

1998 • 275 citations

Nitric Oxide Suppresses Apoptosis via Interrupting Caspase Activation and Mitochondrial Dysfunction in Cultured Hepatocytes

1999 • 264 citations

Accumulation of HIF-1α under the influence of nitric oxide

2001 • 257 citations

DNA Damage by Nitric Oxide

1996 • 248 citations

Endogenous nitric oxide inhibits the synthesis of cyclooxygenase products and interleukin-6 by rat Kupffer cells

1993 • 248 citations

Increased p53 mutation load in nontumorous human liver of Wilson disease and hemochromatosis: Oxyradical overload diseases

2000 • 247 citations

Regulation of Murine Intestinal Inflammation by Reactive Metabolites of Oxygen and Nitrogen

2001 • 245 citations

Tumor-induced regulation of suppressor macrophage nitric oxide and TNF-alpha production. Role of tumor-derived IL-10, TGF-beta, and prostaglandin E2.

1994 • 244 citations

Increased expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in colonic mucosa of patients with active ulcerative colitis

1998 • 241 citations

Hepatitis B and C Virus, Clonorchis sinensis for the Risk of Liver Cancer: A Case-Control Study in Pusan, Korea

1996 • 235 citations

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression

1997 • 234 citations

Chemopreventive properties of a selective inducible nitric oxide synthase inhibitor in colon carcinogenesis, administered alone or in combination with celecoxib, a selective cyclooxygenase-2 inhibitor.

2002 • 229 citations

Coexpression of inducible nitric oxide synthase and COX-2 in hepatocellular carcinoma and surrounding liver: possible involvement of COX-2 in the angiogenesis of hepatitis C virus-positive cases.

2001 • 228 citations

The role of nitric oxide (NO·) in the carcinogenic process

1996 • 225 citations

Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor

1994 • 222 citations

Nitric oxide synthases

1996 • 222 citations

Nitric oxide–mediated inhibition of DNA repair potentiates oxidative DNA damage in cholangiocytes

2001 • 218 citations

Expression of nitric oxide synthases and formation of nitrotyrosine and reactive oxygen species in inflammatory bowel disease

1998 • 216 citations

The Effect of Various Nitric Oxide-Donor Agents on Hydrogen Peroxide-Mediated Toxicity: A Direct Correlation between Nitric Oxide Formation and Protection

1996 • 209 citations

Regulation of the Hypoxia-inducible Factor 1α by the Inflammatory Mediators Nitric Oxide and Tumor Necrosis Factor-α in Contrast to Desferroxamine and Phenylarsine Oxide

2001 • 207 citations

Purification and cDNA sequence of an inducible nitric oxide synthase from a human tumor cell line

1993 • 204 citations

Role of nitric oxide in angiogenesis and microcirculation in tumors.

1998 • 201 citations

Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells.

1994 • 195 citations

Inducible nitric oxide synthase expression, apoptosis, and angiogenesis in in situ and invasive breast carcinomas.

2000 • 194 citations

Nitric Oxide and Oxidative Stress (H₂O₂) Control Mammalian Iron Metabolism by Different Pathways

1996 • 194 citations

Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.

1997 • 193 citations

Role of nitric oxide in tumor progression: lessons from experimental tumors.

1998 • 193 citations

NO: the Primary EDRF

1999 • 192 citations

Role of nitric oxide in inflammation

2001 • 187 citations

Cross‐sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high‐risk area in northeast thailand

1994 • 186 citations

Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth

1999 • 185 citations

Cytokine-induced expression of a nitric oxide synthase in rat renal tubule cells.

1993 • 184 citations

Nitric Oxide Synthase/COX Cross-Talk: Nitric Oxide Activates COX-1 But Inhibits COX-2-Derived Prostaglandin Production

2000 • 182 citations

Nitric Oxide Inhibits Macrophage-Colony Stimulating Factor Gene Transcription in Vascular Endothelial Cells

1995 • 180 citations

Endogenous DNA damage and mutation

2001 • 178 citations

Chemoprevention of colonic aberrant crypt foci by an inducible nitric oxide synthase-selective inhibitor

1999 • 178 citations

Therapy of cancer metastasis by activation of the inducible nitric oxide synthase.

1998 • 175 citations

Inducible Nitric Oxide: An Autoregulatory Feedback Inhibitor of Vascular Inflammation

1998 • 174 citations

Nitric Oxide Synthase Inhibition by NG-Nitro-l-Arginine Methyl Ester Inhibits Tumor-Induced Angiogenesis in Mammary Tumors

1999 • 173 citations

RESPONSE: Re: Relationship Between p53 Mutations and Inducible Nitric Oxide Synthase Expression in Human Colorectal Cancer

1999 • 172 citations

Nitric oxide regulates nitric oxide synthase-2 gene expression by inhibiting NF-κB binding to DNA

1997 • 171 citations

Environmental exposure to asbestos and risk of pleural mesothelioma: review and meta-analysis.

2000 • 170 citations

Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.

1997 • 168 citations

Nitric Oxide-Mediated Regulation of Chemosensitivity in Cancer Cells

2001 • 168 citations

Induction of vascular endothelial growth factor by nitric oxide in human glioblastoma and hepatocellular carcinoma cells

1997 • 167 citations

Inducible nitric oxide synthase expression in chronic viral hepatitis. Evidence for a virus-induced gene upregulation.

1998 • 156 citations

Increased level of exhaled nitric oxide and up-regulation of inducible nitric oxide synthase in patients with primary lung cancer

1998 • 154 citations

Suppression of intestinal polyposis in Apc(Min/+) mice by inhibiting nitric oxide production.

2001 • 142 citations

Physiology and pathophysiology of nitric oxide.

1996 • 141 citations

PROSPECTIVE EVALUATION OF RISK OF CERVICAL CANCER AFTER CYTOLOGICAL EVIDENCE OF HUMAN PAPILLOMAVIRUS INFECTION

1986 • 140 citations

Role of inducible nitric oxide synthase in trinitrobenzene sulphonic acid induced colitis in mice

1999 • 140 citations

Reduced oxidative and nitrosative damage in murine experimental colitis in the absence of inducible nitric oxide synthase

1999 • 133 citations

Role of nitric oxide in genotoxicity: implication for carcinogenesis.

1998 • 133 citations

Induction ofp53 andp21/WAF1/CIP1 expression by nitric oxide and their association with apoptosis in human cancer cells

1996 • 130 citations

Protein–protein interactions controlling nitric oxide synthases

2000 • 130 citations

Activation of nitric oxide synthase gene for inhibition of cancer metastasis

1996 • 127 citations

Oxy-radical induced mutagenesis of hotspot codons 248 and 249 of the human p53 gene.

1994 • 127 citations

Mechanisms for nitric oxide-induced cell death: Involvement of apoptosis

1995 • 120 citations

Cytokine‐induced expression of an inducible type of nitric oxide synthase gene in cultured vascular smooth muscle cells

1993 • 117 citations

Enhanced expression of inducible nitric oxide synthase and nitrotyrosine in gastric mucosa of gastric cancer patients.

1999 • 111 citations

Intrahepatic accumulation of nitrotyrosine in chronic viral hepatitis is associated with histological severity of liver disease

2000 • 109 citations

Human mesothelioma samples overexpress both cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (NOS2): in vitro antiproliferative effects of a COX-2 inhibitor.

2000 • 106 citations

Tumor Cell Nitric Oxide Inhibits Cell Growthin Vitro,but Stimulates Tumorigenesis and Experimental Lung Metastasisin Vivo

1996 • 105 citations

Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine.

1997 • 101 citations

The role of mutant Apc in the development of dysplasia and cancer in the mouse model of dextran sulfate sodium–induced colitis

2001 • 101 citations

Nitric oxide inhibits proliferation of human endothelial cells via a mechanism independent of cGMP

1999 • 97 citations

Mutagenesis associated with nitric oxide production in transgenic SJL mice

1996 • 97 citations

Base Analog and Neighboring Base Effects on Substrate Specificity of Recombinant Human G:T Mismatch-Specific Thymine DNA−Glycosylase

1996 • 97 citations

Peroxynitrite-induced DNA damage in the supF gene: correlation with the mutational spectrum

2000 • 94 citations

Inducible nitric oxide synthase expression in benign prostatic hyperplasia, low‐ and high‐grade prostatic intraepithelial neoplasia and prostatic carcinoma

2001 • 93 citations

Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis.

2000 • 92 citations

Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation

1996 • 90 citations

Suppression of Tumorigenicity and Metastasis of Human Renal Carcinoma Cells by Infection with Retroviral Vectors Harboring the Murine Inducible Nitric Oxide Synthase Gene

1998 • 89 citations

Destruction of Bystander Cells by Tumor Cells Transfected With Inducible Nitric Oxide (NO) Synthase Gene

1997 • 87 citations

Direct correlation between expression of endogenous inducible nitric oxide synthase and regression of M5076 reticulum cell sarcoma hepatic metastases in mice treated with liposomes containing lipopeptide CGP 31362.

1995 • 83 citations

Studies of iron deposits, inducible nitric oxide synthase and nitrotyrosine in a rat model for esophageal adenocarcinoma

1998 • 83 citations

Oxidative Stress and p53 Mutations in the Carcinogenesis of Iron Overload-Associated Hepatocellular Carcinoma

2001 • 81 citations

Expression of inducible nitric oxide synthase in human breast cancer depends on tumor grade

1999 • 81 citations

Significance of nitric oxide in carcinogenesis, tumor progression and cancer therapy.

1998 • 81 citations

Studies on biomarkers in cancer etiology and prevention: a summary and challenge of 20 years of interdisciplinary research

2000 • 79 citations

Genetic Alterations in Ulcerative Colitis‐associated Neoplasia Focusing on APC, K‐ras Gene and Microsatellite Instability

1999 • 78 citations

Etheno adducts in spleen DNA of SJL mice stimulated to overproduce nitric oxide

1998 • 78 citations

Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.

1995 • 77 citations

Mutagenesis associated with nitric oxide production in macrophages

1998 • 74 citations

Reduced sensitivity of inducible nitric oxide synthase-deficient mice to chronic colitis

2001 • 74 citations

Immunohistochemical localization of inducible nitric oxide synthase and 3-nitrotyrosine in rat liver tumors induced by N-nitrosodiethylamine

1999 • 73 citations

Mechanism of inhibition of matrix metalloproteinase-9 induction by NO in vascular smooth muscle cells

2001 • 70 citations

Differential regulation of vascular endothelial growth factor and its receptor fms-like-tyrosine kinase is mediated by nitric oxide in rat renal mesangial cells

1999 • 69 citations

Chronic Hepatitis C Virus Infection in Humans: Induction of Hepatic Nitric Oxide Synthase and Proposed Mechanisms for Carcinogenesis

1997 • 65 citations

NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis, ameliorates interleukin 2-induced capillary leakage and reduces tumour growth in adenocarcinoma-bearing mice

1996 • 65 citations

Specific pattern of p53 phosphorylation during nitric oxide-induced cell cycle arrest

2000 • 64 citations

Bacteriological studies of bile from the gallbladder in patients with carcinoma of the gallbladder, cholelithiasis, common bile duct stones and no gallstones disease.

1994 • 64 citations

Nitric oxide synthase II gene disruption: implications for tumor growth and vascular endothelial growth factor production.

2001 • 62 citations

Nitric Oxide Inhibits Endothelial IL-1β-induced ICAM-1 Gene Expression at the Transcriptional Level Decreasing Sp1 and AP-1 Activity

2001 • 61 citations

Inducible nitric oxide synthase activity in colon biopsies from inflammatory areas: correlation with inflammation intensity in patients with ulcerative colitis but not with Crohn's disease

2000 • 60 citations

Genetic disruption of host nitric oxide synthase II gene impairs melanoma-induced angiogenesis and suppresses pleural effusion

2001 • 57 citations

Introduction to EDRF Research

1993 • 56 citations

Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma.

2001 • 54 citations

Inducible nitric oxide synthase expression in human urinary bladder cancer

2000 • 54 citations

The effect of inhibitors of inducible nitric oxide synthase on chronic colitis in the rhesus monkey.

1997 • 53 citations

Inhibition of NF-κB and HIV-1 Long Terminal Repeat Transcriptional Activation by Inducible Nitric Oxide Synthase 2 Activity

1998 • 52 citations

Activation of inducible nitric oxide synthase results in nitric oxide-mediated radiosensitization of hypoxic EMT-6 tumor cells.

1998 • 50 citations

N-(3-(Aminomethyl)benzyl)acetamidine, an inducible nitric oxide synthase inhibitor, decreases colonic inflammation induced by trinitrobenzene sulphonic acid in rats

2001 • 50 citations

Nitric oxide synthase inhibition results in synergistic anti-tumour activity with melphalan and tumour necrosis factor alpha-based isolated limb perfusions

2000 • 50 citations

Nitric oxide production in relation to spontaneous B-cell lymphoma and myositis in SJL mice.

1995 • 49 citations

Expression of nitric oxide synthase in inflammatory bowel disease is not affected by corticosteroid treatment.

1998 • 49 citations

Differential expression of nitric oxide synthase in human stomach cancer

1999 • 49 citations

Differential expression of inducible nitric oxide synthase mRNA in human brain tumours

1995 • 47 citations

Helicobacter pylori Infection on the Risk of Stomach Cancer and Chronic Atrophic Gastritis

1999 • 46 citations

Nitric oxide-induced mutations in theHPRT gene of human lymphoblastoid TK6 cells and inSalmonella typhimurium

2000 • 46 citations

Bladder cancer in the spinal cord-injured patient with long-term catheterization: a casual relationship?

1992 • 45 citations

Nitric oxide donors, sodium nitroprusside and S-nitroso-N-acetylpenicillamine, stimulate myoblast proliferation in vitro

1999 • 43 citations

Expression of nitric oxide synthase isoforms and nitrotyrosine immunoreactivity by B‐cell non‐Hodgkin’s lymphomas and multiple myeloma

2001 • 42 citations

The Role of Nitric Oxide in the Regulation of Cellular Iron Metabolism

1997 • 40 citations

Role of inducible nitric oxide synthase in dextran sulphate sodium‐induced colitis

2000 • 39 citations

Hepatitis B Virus X Protein Transactivates the Inducible Nitric Oxide Synthase Promoter

1999 • 38 citations

Therapy of human pancreatic carcinoma implants by irinotecan and the oral immunomodulator JBT 3002 is associated with enhanced expression of inducible nitric oxide synthase in tumor-infiltrating macrophages.

2000 • 38 citations

Suppression of azoxymethane-induced colonic aberrant crypt foci by a nitric oxide synthase inhibitor

2000 • 38 citations

Evidence for in vivo peroxynitrite production in human chronic hepatitis

1998 • 36 citations

Mutagenesis of codon 248 of the human p53 tumor suppressor gene by N-ethyl-N-nitrosourea.

1994 • 36 citations

Role of nitric oxide in IL-2 therapy-induced capillary leak syndrome.

1998 • 36 citations

Enhanced Expression of Inducible Nitric Oxide Synthase in Chronic Gastritis With Intestinal Metaplasia

1998 • 35 citations

Nitric oxide production in SJL mice bearing the RcsX lymphoma: a model for in vivo toxicological evaluation of NO.

1996 • 35 citations

Significance of contracted cholecystitis lesions as high risk for gallbladder carcinogenesis

2001 • 33 citations

Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53.

1999 • 33 citations

Activation of nitric oxide synthase is involved in tamoxifen‐induced apoptosis of human erythroleukemia K562 cells

1998 • 32 citations

N^G‐Nitro‐L‐arginine Methyl Ester Inhibits Bone Metastasis after Modified Intracardiac Injection of Human Breast Cancer Cells in a Nude Mouse Model

1997 • 30 citations

Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to 238Pu alpha-particles in human bronchial epithelial cells

1997 • 29 citations

The comparative effects of the NOS inhibitor, nω-nitro-l-arginine, and the haemoxygenase inhibitor, zinc protoporphyrin IX, on tumour blood flow

1998 • 27 citations

Estimation of Relative Risk From Vital Data: Smoking and Cancers of the Lung and Bladder<xref ref-type="fn" rid="FN2">2</xref>

1979 • 26 citations

Role Of Nitric Oxide Synthase Inhibitor In Experimental Colitis Induced By 2,4,6‐Trinitrobenzene Sulphonic Acid In Rats

2001 • 25 citations

Nitric Oxide Synthase Inhibition Promotes Carcinogen-Induced Preneoplastic Changes in the Colon of Rats

2000 • 25 citations

Nitric oxide synthase immunoreactivity in human bladder carcinoma

2001 • 24 citations

Oral Administration of Inducible Nitric Oxide Synthase Inhibitors Reduces Nitric Oxide Synthesis but Has No Effect on the Severity of Experimental Colitis

2000 • 24 citations

Effect of nitric oxide on mouse clonal osteogenic cell, MC3T3-E1, proliferation in vitro.

2001 • 23 citations

Increase in experimental pulmonary metastasis in mice by L-arginine under inhibition of nitric oxide production by NG-nitro-L-arginine methyl ester

1998 • 22 citations

Aminoguanidine Has Both an Anti-Inflammatory Effect on Experimental Colitis and a Proliferative Effect on Colonic Mucosal Cells

1999 • 21 citations

ROLE OF NITRIC OXIDE IN PATHOGENESIS OF SEROTONINE-INDUCED GASTRIC LESIONS IN RATS

1997 • 21 citations

Aminoguanidine prevents concanavalin A-induced hepatitis in mice

2000 • 19 citations

Activation of Microvascular Endothelial Cells in Active Ulcerative Colitis and Detection of Inducible Nitric Oxide Synthase

1998 • 18 citations

Barrett's esophagus and esophageal cancer.

1994 • 18 citations

Intensified Regression of Colon Cancer Liver Metastases in Mice Treated with Irinotecan and the Immunomodulator JBT 3002

2000 • 14 citations

Differing effects of two nitric oxide synthase inhibitors on experimental colitis.

2001 • 13 citations

Deleted Work

1955 • 0 citations