Combretastatin A-4 phosphate as a tumor vascular-targeting agent: early effects in tumors and normal tissues.

Endostatin: An Endogenous Inhibitor of Angiogenesis and Tumor Growth

1997 • 4,504 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Angiostatin induces and sustains dormancy of human primary tumors in mice

1996 • 1,193 citations

Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.

1993 • 785 citations

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

1989 • 770 citations

Microtechnical Demonstration of Phosphatase in Tissue Sections.

1939 • 750 citations

Interstitial pressure gradients in tissue-isolated and subcutaneous tumors: implications for therapy.

1990 • 742 citations

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.

1988 • 680 citations

Combretastatin A-4, an agent that displays potent and selective toxicity toward tumor vasculature.

1997 • 627 citations

Tumor Infarction in Mice by Antibody-Directed Targeting of Tissue Factor to Tumor Vasculature

1997 • 485 citations

Nitric oxide and septic shock

1997 • 309 citations

Anti-vascular approaches to solid tumour therapy: evaluation of combretastatin A4 phosphate.

1999 • 260 citations

Nitric oxide is an important mediator for tumoricidal activity in vivo.

1994 • 249 citations

Antineoplastic agents 322. synthesis of combretastatin A-4 prodrugs.

1995 • 219 citations

Eradication of large solid tumors in mice with an immunotoxin directed against tumor vasculature.

1993 • 203 citations

The interaction with tubulin of a series of stilbenes based on combretastatin A-4

1995 • 175 citations

Vinca alkaloids: Anti-vascular effects in a murine tumour

1993 • 171 citations

Blood Flow Failure as a Major Determinant in the Antitumor Action of Flavone Acetic Acid

1989 • 151 citations

Matrix metalloproteinase inhibitors: Present achievements and future prospects

1997 • 128 citations

Antivascular approaches to solid tumour therapy: evaluation of tubulin binding agents.

1996 • 120 citations

Tumour vasculature as a target for cancer therapy.

1999 • 119 citations

Reduction of Tumor Blood Flow by Flavone Acetic Acid: A Possible Component of Therapy

1989 • 118 citations

Tumor-dependent increased plasma nitrate concentrations as an indication of the antitumor effect of flavone-8-acetic acid and analogues in mice.

1991 • 104 citations

Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine.

1997 • 101 citations

Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine (Ethyol): preclinical aspects.

1994 • 96 citations

Temporal chaos in the microcirculation.

1996 • 93 citations

Anti—vascular approaches to solid tumour therapy: Evaluation of vinblastine and flavone acetic acid

1995 • 83 citations

Clinical trials of antiangiogenic agents

1997 • 65 citations

Antitumor activity of combretastatin-A4 phosphate, a natural product tubulin inhibitor

1996 • 63 citations

Protection of Normal Tissues from the Cytotoxic Effects of Chemotherapy and Radiation by Amifostine (WR-2721): Preclinical Aspects

1995 • 54 citations

Effect of colchicine on human carcinoma

1940 • 52 citations

Modification of tumour blood flow using the hypertensive agent, angiotensin II

1993 • 45 citations

Ischemia reperfusion injury in tumors: the role of oxygen radicals and nitric oxide.

1995 • 45 citations

Nitric oxide in tumour biology and cancer therapy. Part 1: Physiological aspects

1997 • 35 citations

Characterisation of tumour blood flow using a 'tissue-isolated' preparation

1994 • 29 citations

Locomotory response ofPhreatichthys andruzzii Vinciguerra (Pisces, Cyprinidae) to chemical signals of conspecifics and of closely related species

1989 • 26 citations

“ Upstream” Modification of Vasoconstrictor Responses in Rat Epigastric Artery Supplying an Implanted Tumour

1994 • 20 citations

Determination of combretastatin A-4 and its phosphate ester pro-drug in plasma by high-performance liquid chromatography

1999 • 20 citations

The clinical experience with antiangiogenic agents

1995 • 17 citations

Reduced capacity of tumour blood vessels to produce endothelium-derived relaxing factor: significance for blood flow modification

1996 • 17 citations

Metabolic and clonogenic consequences of ischaemia reperfusion insult in solid tumours

1997 • 16 citations

Vascular markers for murine tumours

1989 • 16 citations

Flavone Acetic Acid Stimulates Nitric Oxide and Peroxynitrite Production in Subcutaneous Mouse Tumors

1997 • 14 citations