Inducible nitric oxide synthase: identification of amino acid residues essential for dimerization and binding of tetrahydrobiopterin.

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Nitric oxide synthases: Roles, tolls, and controls

1994 • 2,945 citations

Cloning and Characterization of Inducible Nitric Oxide Synthase from Mouse Macrophages

1992 • 1,914 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

How calmodulin binds its targets: sequence independent recognition of amphiphilic α-helices

1990 • 839 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Macrophage Oxidation of L-Arginine to Nitric Oxide, Nitrite, and Nitrate

1989 • 681 citations

Calmodulin is a subunit of nitric oxide synthase from macrophages.

1992 • 640 citations

Reduced Biopterin as a Cofactor in the Generation of Nitrogen Oxides by Murine Macrophages

1989 • 571 citations

Complete coding sequence of rat tyrosine hydroxylase mRNA.

1985 • 544 citations

Mammalian Nitric Oxide Synthases

1992 • 514 citations

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

1991 • 458 citations

Macrophage nitric oxide synthase subunits. Purification, characterization, and role of prosthetic groups and substrate in regulating their association into a dimeric enzyme.

1993 • 391 citations

Calmodulin-binding domains: just two faced or multi-faceted?

1995 • 368 citations

Sequential induction of heme pathway enzymes during erythroid differentiation of mouse Friend leukemia virus-infected cells.

1976 • 318 citations

Molecular and biochemical characterization of dNOS: a Drosophila Ca2+/calmodulin-dependent nitric oxide synthase.

1995 • 244 citations

The pteridine binding site of brain nitric oxide synthase. Tetrahydrobiopterin binding kinetics, specificity, and allosteric interaction with the substrate domain.

1994 • 218 citations

Evidence for a bidomain structure of constitutive cerebellar nitric oxide synthase.

1994 • 201 citations

Prokaryotic Expression of the Heme- and Flavin-Binding Domains of Rat Neuronal Nitric Oxide Synthase as Distinct Polypeptides: Identification of the Heme-Binding Proximal Thiolate Ligand as Cysteine-415

1995 • 163 citations

Macrophage NO synthase: characterization of isolated oxygenase and reductase domains reveals a head-to-head subunit interaction

1995 • 149 citations

Optical difference spectrophotometry as a probe of rat brain nitric oxide synthase heme-substrate interaction

1993 • 149 citations

Sequence of Two mRNAs Encoding Active Rat Tryptophan Hydroxylase

1988 • 125 citations

Cysteine 184 of endothelial nitric oxide synthase is involved in heme coordination and catalytic activity.

1994 • 117 citations

L-arginine and calmodulin regulation of the heme iron reactivity in neuronal nitric oxide synthase.

1994 • 100 citations

Characterization of Neuronal Nitric Oxide Synthase and a C415H Mutant, Purified from a Baculovirus Overexpression System

1994 • 97 citations

Isolation and sequence of a cDNA clone which contains the complete coding region of rat phenylalanine hydroxylase. Structural homology with tyrosine hydroxylase, glucocorticoid regulation, and use of alternate polyadenylation sites.

1986 • 89 citations

Carboxyl terminus of inducible nitric oxide synthase. Contribution to NADPH binding and enzymatic activity.

1994 • 72 citations

Tetrahydrobiopterin-deficient nitric oxide synthase has a modified heme environment and forms a cytochrome P 420 analog

1995 • 65 citations

Delineation of the catalytic core of phenylalanine hydroxylase and identification of glutamate 286 as a critical residue for pterin function.

1994 • 51 citations

Modular Structure of Neuronal Nitric Oxide Synthase: Localization of the Arginine Binding Site and Modulation by Pterin

1995 • 50 citations

Isolation and expression of rat liver sepiapterin reductase cDNA.

1990 • 38 citations

Localization of cofactor binding sites with monoclonal anti-idiotype antibodies: phenylalanine hydroxylase.

1991 • 37 citations

Structural studies and isolation of cDNA clones providing the complete sequence of rat liver dihydropteridine reductase.

1987 • 30 citations