Significance of nitric oxide in carcinogenesis, tumor progression and cancer therapy.

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Nitric oxide, superoxide, and peroxynitrite: the good, the bad, and ugly

1996 • 5,498 citations

Nitric oxide synthases in mammals

1994 • 2,762 citations

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

1995 • 2,075 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor target cells.

1989 • 1,747 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Targeted disruption of the neuronal nitric oxide synthase gene

1993 • 1,300 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Roles of nitric oxide in tumor growth.

1995 • 791 citations

NO News Is Good News

1992 • 756 citations

Nitric oxide synthase activity in human breast cancer

1995 • 637 citations

Behavioural abnormalities in male mice lacking neuronal nitric oxide synthase

1995 • 603 citations

New insights into the regulation of inducible nitric oxide synthesis

1994 • 582 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

Nitric oxide synthase activity in human gynecological cancer.

1994 • 428 citations

Expression of nitric oxide synthase in human central nervous system tumors.

1995 • 370 citations

Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells.

1995 • 326 citations

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression

1997 • 234 citations

Tumor Cell Nitric Oxide Inhibits Cell Growthin Vitro,but Stimulates Tumorigenesis and Experimental Lung Metastasisin Vivo

1996 • 105 citations

Mechanism of cultured endothelial injury induced by lymphokine-activated killer cells.

1988 • 57 citations

Cloning and characterization of murine endothelial constitutive nitric oxide synthase

1996 • 55 citations

Enzymology, biochemistry and immunology

1992 • 20 citations