Nitric Oxide and Oxidative Stress (H₂O₂) Control Mammalian Iron Metabolism by Different Pathways

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Protein kinases and phosphatases: The Yin and Yang of protein phosphorylation and signaling

1995 • 2,907 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

1988 • 707 citations

Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5' untranslated region of ferritin heavy- and light-subunit mRNAs.

1988 • 684 citations

Measurement of endothelial cell free radical generation: evidence for a central mechanism of free radical injury in postischemic tissues.

1988 • 610 citations

Endothelial-cell heme uptake from heme proteins: induction of sensitization and desensitization to oxidant damage.

1993 • 603 citations

Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide.

1994 • 596 citations

Superoxide and peroxynitrite inactivate aconitases, but nitric oxide does not.

1994 • 585 citations

EPR demonstration of iron-nitrosyl complex formation by cytotoxic activated macrophages.

1990 • 512 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

The Biochemical Pathways of Nitric Oxide Formation from Nitrovasodilators

1991 • 478 citations

Biosynthesis of nitric oxide activates iron regulatory factor in macrophages.

1993 • 409 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction

1989 • 387 citations

Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.

1991 • 349 citations

Purification and characterization of cytosolic aconitase from beef liver and its relationship to the iron-responsive element binding protein.

1992 • 345 citations

Rapid responses to oxidative stress mediated by iron regulatory protein.

1995 • 331 citations

Cellular regulation of the iron-responsive element binding protein: disassembly of the cubane iron-sulfur cluster results in high-affinity RNA binding.

1992 • 324 citations

Evidence that the pathway of transferrin receptor mRNA degradation involves an endonucleolytic cleavage within the 3′ UTR and does not involve poly(A) tail shortening.

1994 • 290 citations

Iron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome

1995 • 285 citations

Generation of EPR-detectable nitrosyl-iron complexes in tumor target cells cocultured with activated macrophages

1991 • 280 citations

Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.

1994 • 273 citations

Reciprocal control of RNA-binding and aconitase activity in the regulation of the iron-responsive element binding protein: role of the iron-sulfur cluster.

1992 • 272 citations

Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity.

1994 • 262 citations

Nitric oxide signaling to iron-regulatory protein: direct control of ferritin mRNA translation and transferrin receptor mRNA stability in transfected fibroblasts.

1995 • 226 citations

Molecular characterization of a second iron-responsive element binding protein, iron regulatory protein 2. Structure, function, and post-translational regulation.

1994 • 221 citations

Reactive oxygen species as cellular messengers

1995 • 218 citations

Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells.

1993 • 210 citations

Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2.

1995 • 209 citations

Translational regulation of mammalian and Drosophila citric acid cycle enzymes via iron-responsive elements.

1996 • 182 citations

Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.

1993 • 169 citations

Oxidative Stress Induces Activation of a Cytosolic Protein Responsible for Control of Iron Uptake

1995 • 146 citations

Recombinant iron‐regulatory factor functions as an iron‐responsive‐element‐binding protein, a translational repressor and an aconitase

1993 • 144 citations

Purification of a Specific Repressor of Ferritin mRNA Translation from Rabbit Liver

1989 • 138 citations

Translational regulation by mRNA/protein interactions in eukaryotic cells: Ferritin and beyond

1993 • 134 citations

Modulation of the RNA-binding activity of a regulatory protein by iron in vitro: switching between enzymatic and genetic function?

1992 • 133 citations

Characterization and Expression of Iron Regulatory Protein 2 (IRP2)

1995 • 127 citations

Protein phosphatase 2A positively and negatively regulates Ras1-mediated photoreceptor development in Drosophila.

1996 • 116 citations

The effect of redox-related species of nitrogen monoxide on transferrin and iron uptake and cellular proliferation of erythroleukemia (K562) cells

1995 • 99 citations

Differential Modulation of the RNA-binding Proteins IRP-1 and IRP-2 in Response to Iron

1995 • 98 citations

11 Control of disease by selective iron depletion: a novel therapeutic strategy utilizing iron chelators

1994 • 97 citations

Iron regulatory factor expressed from recombinant baculovirus: conversion between the RNA-binding apoprotein and Fe-S cluster containing aconitase

1993 • 93 citations

Iron regulates the activity of the iron-responsive element binding protein without changing its rate of synthesis or degradation.

1992 • 75 citations

Cellular pharmacology of deferrioxamine B and derivatives in cultured rat hepatocytes in relation to iron mobilization

1985 • 74 citations

Differential regulation of two related RNA-binding proteins, iron regulatory protein (IRP) and IRPB.

1995 • 69 citations

Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells

1995 • 65 citations

1 Molecular regulation of iron proteins

1994 • 37 citations