The chemistry of DNA damage from nitric oxide and peroxynitrite

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

NITRIC OXIDE AND MACROPHAGE FUNCTION

1997 • 4,106 citations

Biochemistry of Nitric Oxide and Its Redox-Activated Forms

1992 • 2,725 citations

Peroxynitrite oxidation of sulfhydryls.

1991 • 2,479 citations

A redox-based mechanism for the neuroprotective and neurodestructive effects of nitric oxide and related nitroso-compounds

1993 • 2,423 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Peroxynitrite-mediated tyrosine nitration catalyzed by superoxide dismutase

1992 • 1,499 citations

Formation of nitric oxide-derived inflammatory oxidants by myeloperoxidase in neutrophils

1998 • 1,494 citations

NO at work

1994 • 1,493 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

1994 • 1,065 citations

Oxidative Damage and Tyrosine Nitration from Peroxynitrite

1996 • 990 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

MUTAGENESIS BY APURINIC/APYRIMIDINIC SITES

1986 • 884 citations

Nitric Oxide: Pathophysiological Mechanisms

1995 • 876 citations

Formation of Reactive Nitrogen Species during Peroxidase-catalyzed Oxidation of Nitrite

1997 • 778 citations

Kinetics of superoxide dismutase- and iron-catalyzed nitration of phenolics by peroxynitrite

1992 • 758 citations

Biological Roles of Nitric Oxide

1992 • 731 citations

Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury.

1996 • 730 citations

Soluble Guanylate Cyclase from Bovine Lung: Activation with Nitric Oxide and Carbon Monoxide and Spectral Characterization of the Ferrous and Ferric States

1994 • 641 citations

Oxidation of nitrogen oxides by bound dioxygen in hemoproteins

1981 • 633 citations

Expression of inducible nitric oxide synthase and nitrotyrosine in colonic epithelium in inflammatory bowel disease

1996 • 588 citations

Rate of chain breakage at apurinic sites in double-stranded deoxyribonucleic acid

1972 • 586 citations

Rapid reaction between peroxonitrite ion and carbon dioxide: Implications for biological activity

1995 • 506 citations

Advances in second messenger and phosphoprotein research

1992 • 481 citations

Reactions of the bioregulatory agent nitric oxide in oxygenated aqueous media: Determination of the kinetics for oxidation and nitrosation by intermediates generated in the nitric oxide/oxygen reaction

1993 • 474 citations

Inhibition of tumor cell ribonucleotide reductase by macrophage-derived nitric oxide.

1991 • 436 citations

DNA Damage Induced by Peroxynitrite: Subsequent Biological Effects

1997 • 433 citations

Reaction Kinetics for Nitrosation of Cysteine and Glutathione in Aerobic Nitric Oxide Solutions at Neutral pH. Insights into the Fate and Physiological Effects of Intermediates Generated in the NO/O2 Reaction

1994 • 384 citations

Modulation of Superoxide-dependent Oxidation and Hydroxylation Reactions by Nitric Oxide

1996 • 355 citations

Formation of 8‐nitroguanine in DNA treated with peroxynitrite in vitro and its rapid removal from DNA by depurination

1995 • 343 citations

The surprising life of NITRIC OXIDE

1993 • 316 citations

Mechanism of Carbon Dioxide-Catalyzed Oxidation of Tyrosine by Peroxynitrite

1996 • 297 citations

Photosensitized formation of 7,8-dihydro-8-oxo-2'-deoxyguanosine (8-hydroxy-2'-deoxyguanosine) in DNA by riboflavin: a nonsinglet oxygen-mediated reaction

1992 • 295 citations

Formation of 8-nitroguanine by the reaction of guanine with peroxynitrite in vitro

1995 • 289 citations

Kinetics of the Reaction of Nitric Oxide with Oxygen in Aqueous Solutions

1994 • 288 citations

Nitric Oxide Regulation of Tissue Free Radical Injury

1996 • 278 citations

Acceleration of Peroxynitrite Oxidations by Carbon Dioxide

1996 • 277 citations

Production of nitric oxide and superoxide by activated macrophages and killing of Leishmania major

1994 • 264 citations

Nitric Oxide Induces Oxidative Damage in Addition to Deamination in Macrophage DNA

1995 • 258 citations

DNA Damage by Nitric Oxide

1996 • 248 citations

Mammalian synthesis of nitrite, nitrate, nitric oxide, and N-nitrosating agents

1988 • 243 citations

A stable solid that generates hydroxyl radical upon dissolution in aqueous solutions: reaction with proteins and nucleic acid

1992 • 229 citations

Guanine Radical Cations Are Precursors of 7,8-Dihydro-8-oxo-2‘-deoxyguanosine But Are Not Precursors of Immediate Strand Breaks in DNA

1996 • 206 citations

Nitric oxide, a biological effector

1991 • 203 citations

„REVERSIBLE” DNA

1961 • 190 citations

Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages.

1994 • 187 citations

Peroxynitrite Causes DNA Nicks in Plasmid pBR322

1995 • 185 citations

[13] Nitric oxide-cyclic GMP signal transduction system

1996 • 183 citations

The Nitric Oxide–Cyclic GMP Signal Transduction System for Intracellular and Intercellular Communication

1994 • 177 citations

Nitric Oxide-induced Deamination of Cytosine and Guanine in Deoxynucleosides and Oligonucleotides

1998 • 176 citations

Peroxynitrite Mediated Oxidation of Purine Bases of Nucleosides and Isolated DNA

1996 • 174 citations

Effects of carbon dioxide/bicarbonate on induction of DNA single‐strand breaks and formation of 8‐nitroguanine, 8‐oxoguanine and base‐propenal mediated by peroxynitrite

1996 • 168 citations

Quantitation of 8-Oxoguanine and Strand Breaks Produced by Four Oxidizing Agents

1997 • 163 citations

Kinetic Analysis of the Fate of Nitric Oxide Synthesized by Macrophages in Vitro

1995 • 160 citations

DNA damage by peroxynitrite characterized with DNA repair enzymes

1996 • 159 citations

No-induced oxidative stress and glutathione metabolism in rodent and human cells

1996 • 158 citations

Nitrous Acid And Nitrosation

1959 • 152 citations

Cytotoxicity of nitric oxide in Fu5 rat hepatoma cells: evidence for co-operative action with hydrogen peroxide

1993 • 127 citations

Photosensitized Reaction of 8-Oxo-7,8-dihydro-2‘-deoxyguanosine: Identification of 1-(2-Deoxy-β-<scp>d</scp>-erythro-pentofuranosyl)cyanuric Acid as the Major Singlet Oxygen Oxidation Product

1996 • 124 citations

Nitric Oxide in Cells

1992 • 121 citations

Kinetics of N-Nitrosation in Oxygenated Nitric Oxide Solutions at Physiological pH: Role of Nitrous Anhydride and Effects of Phosphate and Chloride

1995 • 121 citations

Kinetics of S-Nitrosation of Thiols in Nitric Oxide Solutions

1996 • 121 citations

Permeability of Nitric Oxide through Lipid Bilayer Membranes

1996 • 120 citations

[38] Stopped-flow, rapid mixing measurements of ligand binding to hemoglobin and red cells

1981 • 117 citations

Nitric oxide (NO•), the only nitrogen monoxide redox form capable of activating soluble guanylyl cyclase

1996 • 107 citations

Pancreatic islet cells are highly susceptible towards the cytotoxic effects of chemically generated nitric oxide

1993 • 103 citations

In vivo dosimetry of 4-aminobiphenyl in rats via a cysteine adduct in hemoglobin.

1984 • 100 citations

Inhibition of Ribonucleotide Reductase by Nitric Oxide Derived from Thionitrites: Reversible Modifications of Both Subunits

1995 • 99 citations

Isolation and Characterization of a Novel Product, 2‘-Deoxyoxanosine, from 2‘-Deoxyguanosine, Oligodeoxynucleotide, and Calf Thymus DNA Treated by Nitrous Acid and Nitric Oxide

1996 • 97 citations

Mutagenesis associated with nitric oxide production in transgenic SJL mice

1996 • 97 citations

Competitive reactions of peroxynitrite with 2′-deoxyguanosine and 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxodG): Relevance to the formation of 8-oxodG in DNA exposed to peroxynitrite

1996 • 91 citations

Mutations induced by saturated aqueous nitric oxide in the pSP189 supF gene in human Ad293 and E. coli MBM7070 cells

1993 • 91 citations

A Mechanistic Analysis of Nitric Oxide-Induced Cellular Toxicity

1997 • 90 citations

An Adduct between Peroxynitrite and 2‘-Deoxyguanosine: 4,5-Dihydro-5-hydroxy-4-(nitrosooxy)-2‘-deoxyguanosine

1996 • 90 citations

Iron-mediated DNA damage: Sensitive detection of DNA strand breakage catalyzed by iron

1992 • 87 citations

The surprising life of nitric oxide

1993 • 78 citations

The influence of delivery rate on the chemistry and biological effects of nitric oxide

1993 • 76 citations

Purification and properties of mitochondrial uracil-DNA glycosylase from rat liver

1988 • 73 citations

Growth and viability of macrophages continuously stimulated to produce nitric oxide

1997 • 70 citations

Methylene blue-mediated photooxidation of 7,8-dihydro-8-oxo-2′-deoxyguanosine

1995 • 62 citations

13. Nitrosation, diazotisation, and deamination. Part I. Principles, background, and method for the kinetic study of diazotisation

1958 • 41 citations

DNA Damage and Cytotoxicity Caused by Nitric Oxide

1994 • 36 citations

Nitric oxide production in SJL mice bearing the RcsX lymphoma: a model for in vivo toxicological evaluation of NO.

1996 • 35 citations

Modification of macrophage glyceraldehyde-3-phosphate dehydrogenase in response to nitric oxide

1996 • 33 citations

Isoforms of Nitric Oxide Synthase and the Nitric Oxide-Cyclic Gmp Signal Transduction System

1993 • 8 citations

The chemistry of nitric oxide-induced deamination and cross-linking of DNA

1997 • 2 citations

Deleted Work

1955 • 0 citations