Nitric oxide-induced apoptosis: p53-dependent and p53-independent signalling pathways

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

WAF1, a potential mediator of p53 tumor suppression

1993 • 8,360 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

p53 is required for radiation-induced apoptosis in mouse thymocytes

1993 • 2,911 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Nitric oxide, a novel neuronal messenger

1992 • 1,864 citations

NO at work

1994 • 1,493 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

DNA damage and mutation in human cells exposed to nitric oxide in vitro.

1992 • 980 citations

p53-Dependent apoptosis in the absence of transcriptional activation of p53-target genes

1994 • 857 citations

DNA strand breaks: the DNA template alterations that trigger p53-dependent DNA damage response pathways.

1994 • 850 citations

p53 and E2F-1 cooperate to mediate apoptosis.

1994 • 844 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Mediation of c-Myc-Induced Apoptosis by p53

1994 • 741 citations

DNA damage can induce apoptosis in proliferating lymphoid cells via p53-independent mechanisms inhibitable by Bcl-2

1994 • 671 citations

Glucocorticoids activate a suicide process in thymocytes through an elevation of cytosolic Ca2+ concentration

1989 • 549 citations

Autoradiography using storage phosphor technology

1990 • 531 citations

p53 expression in nitric oxide‐induced apoptosis

1994 • 403 citations

On the Mechanism of NO Release from Sydnonimines

1989 • 305 citations

Inactivation of Glutathione Peroxidase by Nitric Oxide

1995 • 304 citations

Nitric oxide and nitric oxide-generating agents induce a reversible inactivation of protein kinase C activity and phorbol ester binding.

1993 • 302 citations

Role of Cysteine Residues in Regulation of p53 Function

1995 • 301 citations

Peroxynitrite-induced Apoptosis in HL-60 Cells

1995 • 300 citations

Molecular controls of growth arrest and apoptosis: p53-dependent and independent pathways.

1995 • 282 citations

p53 induction is associated with neuronal damage in the central nervous system.

1994 • 262 citations

Nitric Oxide Induces Oxidative Damage in Addition to Deamination in Macrophage DNA

1995 • 258 citations

DNA Strand Breaks: the DNA Template Alterations That Trigger p53-Dependent DNA Damage Response Pathways

1994 • 198 citations

Nitric oxide-induced apoptosis in RAW 264.7 macrophages is antagonized by protein kinase C- and protein kinase A-activating compounds.

1995 • 178 citations

Nitric oxide causes inactivation of the low molecular weight phosphotyrosine protein phosphatase.

1994 • 143 citations

Cell death induced by β-amyloid 1–40 in MES 23.5 hybrid clone: the role of nitric oxide and NMDA-gated channel activation leading to apoptosis

1995 • 137 citations

Modulation of AP‐1 activity by nitric oxide (NO) in vitro: NO‐mediated modulation of AP‐1

1994 • 109 citations

Nitric oxide induced poly(ADP‐ribose) polymerase cleavage in RAW 264.7 macrophage apoptosis is blocked by Bcl‐2

1996 • 103 citations

Inhibition of cell growth mediated by plasmids encoding p53 anti-sense.

1987 • 99 citations

Direct involvement of p53 in programmed cell death of oligodendrocytes.

1995 • 89 citations

The iron-responsive element binding protein: a target for synaptic actions of nitric oxide.

1994 • 78 citations

Protein thiol modification and apoptotic cell death as cGMP-independent nitric oxide (NO) signaling pathways

1995 • 76 citations

Formation of high molecular mass DNA fragments is a marker of apoptosis in the human leukaemic cell line, U937

1994 • 63 citations

Wild-type p53 is required for apoptosis induced by growth factor deprivation in factor-dependent leukaemic cells

1994 • 62 citations

p53: DNA damage, DNA repair, and apoptosis

1995 • 50 citations

Role of Retinoblastoma Gene Product in p53-Mediated DNA Damage Response

1994 • 23 citations