Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma.

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

Cytokine therapeutics: lessons from interferonalpha.

1994 • 703 citations

The multifaceted roles of nitric oxide in cancer

1998 • 686 citations

Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas.

1995 • 442 citations

Induction and chemotherapeutic response of two transplantable ductal adenocarcinomas of the pancreas in C57BL/6 mice.

1984 • 341 citations

Interactive effects of nitric oxide and the p53 tumor suppressor gene in carcinogenesis and tumor progression

1997 • 234 citations

Enhancement by Interferon of the Expression of Surface Antigens on Murine Leukemia L 1210 Cells

1973 • 204 citations

Downregulation of interleukin 8 gene expression in human fibroblasts: unique mechanism of transcriptional inhibition by interferon.

1992 • 184 citations

Therapy of cancer metastasis by activation of the inducible nitric oxide synthase.

1998 • 175 citations

Antiproliferative Potencies of Interferons on Melanoma Cell Lines and Xenografts: Higher Efficacy of Interferon β

1992 • 144 citations

Why Do So Many Cancer Patients Fail to Respond to Interferon Therapy?

1996 • 101 citations

Inhibitory effects of interferon on the expression of genes regulated by platelet-derived growth factor.

1985 • 97 citations

Influence of nitric oxide synthase II gene disruption on tumor growth and metastasis.

2000 • 92 citations

Treatment of a human breast cancer xenograft with an adenovirus vector containing an interferon gene results in rapid regression due to viral oncolysis and gene therapy.

1996 • 89 citations

Differential regulation of glycosaminoglycan, fibronectin, and collagenase production in cultured human dermal fibroblasts by interferon-alpha,-beta, and-gamma

1989 • 87 citations

Mechanism of Interferon Beta-Induced Squamous Differentiation and Programmed Cell Death in Human Non--Small--Cell Lung Cancer Cell Lines

1995 • 61 citations

Genetic disruption of host nitric oxide synthase II gene impairs melanoma-induced angiogenesis and suppresses pleural effusion

2001 • 57 citations

Regulation of interleukin 8 expression in human malignant melanoma cells.

1998 • 50 citations

Interferons

1995 • 43 citations

Effects of interferons and other cytokines on tumors in animals: A review

1991 • 41 citations

Direct correlation between nitric oxide synthase II inducibility and metastatic ability of UV-2237 murine fibrosarcoma cells carrying mutant p53.

1999 • 33 citations

Interferons in Malignancy: Biological Products or Biological Response Modifiers?

1988 • 32 citations

Interferons and the tumor cell

1996 • 27 citations

Inhibitory effects of alpha-interferon on epidermal growth factor-mediated receptor-dependent events.

1993 • 18 citations

Experimental animal models of pancreatic cancer (review).

2000 • 13 citations

Interferon use in solid tumors

1998 • 6 citations