Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs.

1986 • 6,585 citations

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

2001 • 644 citations

Tumoritropic and lymphotropic principles of macromolecular drugs.

1989 • 576 citations

Antagonistic action of imidazolineoxyl N-oxides against endothelium-derived relaxing factor/.bul.NO (nitric oxide) through a radical reaction

1993 • 569 citations

Conjugates of anticancer agents and polymers: advantages of macromolecular therapeutics in vivo

1992 • 548 citations

Quantitative and kinetic characterization of nitric oxide and EDRF released from cultured endothelial cells

1988 • 342 citations

Use of oily contrast medium for selective drug targeting to tumor: enhanced therapeutic effect and X-ray image.

1984 • 283 citations

A New Approach to Cancer Chemotherapy: Selective Enhancement of Tumor Blood Flow With Angiotensin II<xref ref-type="fn" rid="fn2">2</xref><xref ref-type="fn" rid="fn3">3</xref>

1981 • 268 citations

SMANCS and polymer-conjugated macromolecular drugs: advantages in cancer chemotherapy

1991 • 209 citations

Microvascular architecture of experimental colon tumors in the rat.

1990 • 174 citations

Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue

1988 • 157 citations

Therapeutic Effects of Imidazolineoxyl N-Oxide Against Endotoxin Shock through Its Direct Nitric Oxide-Scavenging Activity

1994 • 142 citations

Purification and identification of [hydroxyprolyl3]bradykinin in ascitic fluid from a patient with gastric cancer.

1988 • 127 citations

Increased Vascular Permeability in Organs Mediated by the Systemic Administration of Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 in Mice

1988 • 115 citations

Kinin‐generating Cascade in Advanced Cancer Patients and in vitro Study

1991 • 103 citations

Medial regression and its functional significance in tumor-supplying host arteries. A morphometric study of hepatic arteries in human livers with hepatocellular carcinoma

1987 • 46 citations

Comparison of cyclic GMP in human internal mammary artery and saphenous vein: implications for coronary artery bypass graft patency

1992 • 34 citations

Increase in Tumor Vascular Area Due to Increased Blood Flow by Angiotensin II in Rats

1985 • 32 citations

Release of Multiple Endothelium-Derived Relaxing Factors from Porcine Coronary Arteries

1992 • 20 citations