The role of nitric oxide (NO·) in the carcinogenic process

Methods in Enzymology , Vol

1966 • 26,261 citations

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

NITRIC OXIDE: A Physiologic Messenger Molecule

1994 • 2,299 citations

The Reaction of no With Superoxide

1993 • 2,133 citations

Hypertension in mice lacking the gene for endothelial nitric oxide synthase

1995 • 2,075 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

NO at work

1994 • 1,493 citations

Altered responses to bacterial infection and endotoxic shock in mice lacking inducible nitric oxide synthase

1995 • 1,454 citations

Nitric oxide synthase structure and mechanism

1993 • 1,342 citations

Peroxynitrite, a cloaked oxidant formed by nitric oxide and superoxide

1992 • 1,319 citations

Altered immune responses in mice lacking inducible nitric oxide synthase

1995 • 1,296 citations

DNA Deaminating Ability and Genotoxicity of Nitric Oxide and its Progenitors

1991 • 1,223 citations

Nitric Oxide Activation of Poly(ADP-Ribose) Synthetase in Neurotoxicity

1994 • 1,138 citations

Peroxynitrite formation from macrophage-derived nitric oxide

1992 • 1,118 citations

Chronic infections and inflammatory processes as cancer risk factors: possible role of nitric oxide in carcinogenesis

1994 • 1,065 citations

The essentials of DNA methylation

1992 • 960 citations

Increased cell division as a cause of human cancer.

1990 • 894 citations

Nitric Oxide: Pathophysiological Mechanisms

1995 • 876 citations

Nitric oxide synthase: Aspects concerning structure and catalysis

1994 • 865 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages

1993 • 782 citations

Too Many Rodent Carcinogens: Mitogenesis Increases Mutagenesis

1990 • 773 citations

Nitric oxide-mediated apoptosis in murine peritoneal macrophages.

1993 • 674 citations

Bactericidal activity of peroxynitrite

1992 • 436 citations

p53 expression in nitric oxide‐induced apoptosis

1994 • 403 citations

Activated murine macrophages induce apoptosis in tumor cells through nitric oxide-dependent or -independent mechanisms.

1994 • 372 citations

Metabolic fate of L-arginine in relation to microbiostatic capability of murine macrophages.

1990 • 356 citations

Quantitative estimation of endogenous nitrosation in humans by monitoring N-nitrosoproline excreted in the urine.

1981 • 346 citations

Apoptotic Cell Death Triggered by Nitric Oxide in Pancreatic β-Cells

1995 • 343 citations

Suppression of adjuvant-induced arthritis by selective inhibition of inducible nitric oxide synthase

1995 • 306 citations

Inactivation of Glutathione Peroxidase by Nitric Oxide

1995 • 304 citations

Formation and Metabolism of Alkylated Nucleosides: Possible Role in Carcinogenesis by Nitroso Compounds and Alkylating Agents

1977 • 304 citations

Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization.

1993 • 275 citations

Inactivation of the Poly(ADP-ribose) Polymerase Gene Affects Oxygen Radical and Nitric Oxide Toxicity in Islet Cells

1995 • 270 citations

Stimulated Human Phagocytes Produce Cytogenetic Changes in Cultured Mammalian Cells

1983 • 262 citations

Nitric Oxide Induces Oxidative Damage in Addition to Deamination in Macrophage DNA

1995 • 258 citations

A stable solid that generates hydroxyl radical upon dissolution in aqueous solutions: reaction with proteins and nucleic acid

1992 • 229 citations

Agonist-modulated Palmitoylation of Endothelial Nitric Oxide Synthase

1995 • 220 citations

N‐Monomethyl arginine, an inhibitor of nitric oxide synthase, suppresses the development of adjuvant arthritis in rats

1994 • 213 citations

Peroxynitrite-induced mutation spectra of pSP189 following replication in bacteria and in human cells

1996 • 212 citations

Nitromation of amines by stimulated macrophages

1987 • 208 citations

Binuclear [2Fe-2S] Clusters in the Escherichia coli SoxR Protein and Role of the Metal Centers in Transcription

1995 • 206 citations

Inverse correlation between expression of inducible nitric oxide synthase activity and production of metastasis in K-1735 murine melanoma cells.

1994 • 195 citations

Interleukin-1β-Induced Nitric Oxide Production Activates Apoptosis in Pancreatic RINm5F Cells

1994 • 194 citations

Nitric oxide and cGMP analogs activate transcription from AP‐1‐responsive promoters in mammalian cells

1995 • 193 citations

Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages.

1994 • 187 citations

Peroxynitrite Causes DNA Nicks in Plasmid pBR322

1995 • 185 citations

The Fpg protein, a DNA repair enzyme, is inhibited by the biomediator nitric oxide in vitro and in vivo

1994 • 168 citations

Kinetic Analysis of the Fate of Nitric Oxide Synthesized by Macrophages in Vitro

1995 • 160 citations

L-Arginine is a precursor for nitrate biosynthesis in humans

1989 • 133 citations

Roles of nitric oxide in inducible resistance of Escherichia coli to activated murine macrophages

1995 • 130 citations

Kinetics of N-Nitrosation in Oxygenated Nitric Oxide Solutions at Physiological pH: Role of Nitrous Anhydride and Effects of Phosphate and Chloride

1995 • 121 citations

Oligomerization of Endothelial Nitric Oxide Synthase

1995 • 115 citations

Multifunctional role of nitric oxide in inflammation

1994 • 105 citations

Metabolism and Excretion of Methylamines in Rats

1994 • 102 citations

Inhibition of Ribonucleotide Reductase by Nitric Oxide Derived from Thionitrites: Reversible Modifications of Both Subunits

1995 • 99 citations

Nitric-Oxide Kills Hepatocytes by Mobilizing Mitochondrial Calcium

1994 • 94 citations

Apoptotic cell death triggered by nitric oxide in pancreatic beta-cells

1995 • 80 citations

Nitrosation by stimulated macrophages. Inhibitors, enhancers and substrates

1989 • 78 citations

The influence of delivery rate on the chemistry and biological effects of nitric oxide

1993 • 76 citations

Influence of ascorbic acid dose on N-nitrosoproline formation in humans

1987 • 74 citations

Elevated formation of nitrate and N-nitrosodimethylamine in woodchucks (Marmota monax) associated with chronic woodchuck hepatitis virus infection.

1991 • 68 citations

Evaluation of the cocarcinogenic effect of wounding in Rous sarcoma virus tumorigenesis.

1989 • 57 citations

Nitric oxide production in relation to spontaneous B-cell lymphoma and myositis in SJL mice.

1995 • 49 citations

Endogenous incorporation of nitric oxide from L-arginine into N-nitrosomorpholine sitmulated by Escherichia coli lipopolysaccharide in the rat

1991 • 48 citations

Nitric oxide and the post-transcriptional control of cellular iron traffic

1994 • 46 citations

Nitrosamines and related N-nitroso compounds. Chemistry and biochemistry

1995 • 44 citations

Nitrat biosynthesis in rats, ferrets and humans. Precursor studies with L-arginine

1990 • 42 citations

Nitrous acid cross-links duplex DNA fragments through deoxyguanosine residues at the sequence 5'-CG

1991 • 39 citations

in vivo nitrosation of amidopyrine in humans: use of ‘ethanol effect’ for biological monitoring of N-nitrosodimethylamine in urine

1985 • 35 citations

Mutagenicity of nitric oxide is not caused by deamination of cytosine or 5-methylcytosine in double-stranded DNA

1994 • 35 citations

Implication of nitric oxide synthase in carcinogenesis: analysis of the human inducible nitric oxide synthase gene

1995 • 10 citations