Induction of haem oxygenase-1 by nitric oxide and ischaemia in experimental solid tumours and implications for tumour growth

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Bilirubin Is an Antioxidant of Possible Physiological Importance

1987 • 3,406 citations

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

1989 • 3,308 citations

THE HEME OXYGENASE SYSTEM:A Regulator of Second Messenger Gases

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Nitric oxide: A cytotoxic activated macrophage effector molecule

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The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase.

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Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis.

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Roles of nitric oxide in tumor growth.

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Cloning and expression of cDNA for rat heme oxygenase.

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Nitric oxide synthase activity in human gynecological cancer.

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Carbon monoxide: an endogenous modulator of sinusoidal tone in the perfused rat liver.

1995 • 388 citations

Expression of nitric oxide synthase in human central nervous system tumors.

1995 • 370 citations

Cobalt Induction of Hepatic Heme Oxygenase; with Evidence That Cytochrome P -450 Is Not Essential for This Enzyme Activity

1974 • 261 citations

Loss and Degradation of Enzyme-bound Heme Induced by Cellular Nitric Oxide Synthesis

1995 • 237 citations

In vivo EPR detection and imaging of endogenous nitric oxide in lipopolysaccharide-treated mice

1996 • 235 citations

Activation of Human Neutrophil Procollagenase by Nitrogen Dioxide and Peroxynitrite: A Novel Mechanism for Procollagenase Activation Involving Nitric Oxide

1997 • 226 citations

Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor

1994 • 222 citations

Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma.

1996 • 221 citations

Nitrogen oxide‐induced autoprotection in isolated rat hepatocytes

1995 • 211 citations

Modulation of enhanced vascular permeability in tumors by a bradykinin antagonist, a cyclooxygenase inhibitor, and a nitric oxide scavenger.

1998 • 211 citations

Production of angiogenic activity by human monocytes requires an L-arginine/nitric oxide-synthase-dependent effector mechanism.

1994 • 205 citations

Carbon monoxide: a role in carotid body chemoreception.

1995 • 194 citations

Role of nitric oxide in tumor progression: lessons from experimental tumors.

1998 • 193 citations

Selective inhibition of inducible nitric oxide synthase inhibits tumor growth in vivo: studies with 1400W, a novel inhibitor.

1997 • 193 citations

Induction of Heme Oxygenase-1 Expression in Vascular Smooth Muscle Cells

1997 • 192 citations

Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages.

1994 • 187 citations

Zinc · protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat

1981 • 186 citations

Inhibitors of nitric oxide synthase selectively reduce flow in tumour‐associated neovasculature

1992 • 179 citations

Excessive production of nitric oxide in rat solid tumor and its implication in rapid tumor growth

1996 • 173 citations

Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue

1988 • 157 citations

Expression of Heme Oxygenase and Inducible Nitric Oxide Synthase mRNA in Human Brain Tumors

1996 • 120 citations

Increased brain tumor microvessel permeability after intracarotid bradykinin infusion is mediated by nitric oxide.

1996 • 112 citations

Increased expression of heme oxygenase mRNA in rat brain following transient forebrain ischemia

1994 • 103 citations

Inhibition of nitric oxide synthase induces a selective reduction in tumor blood flow that is reversible with L-arginine.

1997 • 101 citations

Expression of Heme Oxygenase Isozyme mRNAs in the Human Brain and Induction of Heme Oxygenase‐1 by Nitric Oxide Donors

1996 • 97 citations

Induction of iron-derived EPR signals in murine cancers by nitric oxide. Evidence for multiple intracellular targets.

1994 • 90 citations

Nanomolar Quantification and Identification of Various Nitrosothiols by High Performance Liquid Chromatography Coupled with Flow Reactors of Metals and Griess Reagent

1997 • 81 citations

Expression of inducible nitric oxide synthase and its involvement in pulmonary granulomatous inflammation in rats.

1996 • 70 citations

A New Monoclonal Antibody, TRPM-3, Binds Specifically to Certain Rat Macrophage Populations: Immunohistochemical and Immunoelectron Microscopic Analysis

1987 • 60 citations

Induction of nitric oxide synthase in the neo‐vasculature of experimental tumours in mice

1993 • 59 citations

Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation.

1978 • 57 citations

Induction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-nitro-L-arginine.

1994 • 43 citations

Expression of heme oxygenase in arsenic-resistant human lung adenocarcinoma cells

1994 • 38 citations

The Influence of Nitric Oxide on Tumour Vascular Tone

1995 • 20 citations

Reduction of hepatic metastases in rabbits by administration of an oily anticancer agent into the portal vein.

1987 • 15 citations

Quantitative measurement of heme oxygenase-1 in the human renal adenocarcinoma

1996 • 13 citations