Role of nitric oxide in tumor microcirculation. Blood flow, vascular permeability, and leukocyte-endothelial interactions.

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

1983 • 3,942 citations

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.

1995 • 3,139 citations

Nitric oxide: an endogenous modulator of leukocyte adhesion.

1991 • 3,079 citations

Nitric oxide: A cytotoxic activated macrophage effector molecule

1988 • 2,050 citations

Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines.

1995 • 1,762 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Transport of molecules across tumor vasculature

1987 • 856 citations

Roles of nitric oxide in tumor growth.

1995 • 791 citations

Endothelium‐derived nitric oxide: actions and properties

1989 • 686 citations

The 1991 Ulf von Euler Lecture:The <scp>l</scp>‐arginine: nitric oxide pathway

1992 • 654 citations

Nitric oxide synthase activity in human breast cancer

1995 • 637 citations

Nitric oxide modulates microvascular permeability

1992 • 564 citations

Synthesis of nitric oxide from <scp>l</scp>-arginine by neutrophils. Release and interaction with superoxide anion

1989 • 529 citations

Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial windows.

1994 • 463 citations

During angiogenesis, vascular endothelial growth factor regulate natural killer cell adhesion to tumor endothelium

1996 • 449 citations

Nitric oxide synthase activity in human gynecological cancer.

1994 • 428 citations

Expression of nitric oxide synthase in human central nervous system tumors.

1995 • 370 citations

Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice.

1992 • 368 citations

Application of the “two-slit” photometric technique to the measurement of microvascular volumetric flow rates

1978 • 309 citations

The induction of nitric oxide synthase and intestinal vascular permeability by endotoxin in the rat

1993 • 295 citations

Inhibition of endothelial-derived nitric oxide promotes P-selectin expression and actions in the rat microcirculation

1994 • 283 citations

Endothelium-derived relaxing factor reduces platelet adhesion to bovine endothelial cells.

1988 • 263 citations

Cyanine dye labeling reagents—carboxymethylindocyanine succinimidyl esters

1990 • 252 citations

Quantitation and physiological characterization of angiogenic vessels in mice: effect of basic fibroblast growth factor, vascular endothelial growth factor/vascular permeability factor, and host microenvironment.

1996 • 235 citations

Enhanced Vascular Permeability in Solid Tumor Is Mediated by Nitric Oxide and Inhibited by Both New Nitric Oxide Scavenger and Nitric Oxide Synthase Inhibitor

1994 • 222 citations

Microvascular Permeability of Albumin, Vascular Surface Area, and Vascular Volume Measured in Human Adenocarcinoma LS174T Using Dorsal Chamber in SCID Mice

1993 • 207 citations

Inhibitors of nitric oxide synthase selectively reduce flow in tumour‐associated neovasculature

1992 • 179 citations

Transforming growth factor-beta 1 inhibits the production of IL-8 and the transmigration of neutrophils through activated endothelium.

1996 • 162 citations

Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue

1988 • 157 citations

Tumor necrosis factor alpha-induced leukocyte adhesion in normal and tumor vessels: effect of tumor type, transplantation site, and host strain.

1995 • 127 citations

Nitric Oxide Affects Microvascular Permeability in the Intact and Inflamed Vasculature

1995 • 123 citations

Increased Vascular Permeability in Organs Mediated by the Systemic Administration of Lymphokine-Activated Killer Cells and Recombinant Interleukin-2 in Mice

1988 • 115 citations

Increased brain tumor microvessel permeability after intracarotid bradykinin infusion is mediated by nitric oxide.

1996 • 112 citations

Leukocyte-endothelial adhesion and angiogenesis in tumors

1996 • 105 citations

Platelet Activating Factor Modulates Microvascular Permeability through Nitric Oxide Synthesis

1995 • 98 citations

A comparison of tumor and normal tissue microvascular hematocrits and red cell fluxes in a rat window chamber model

1993 • 89 citations

Imaging of leukocytes within the rat brain cortex in vivo

1991 • 70 citations

NG-nitro-L-arginine methyl ester, an inhibitor of nitric oxide synthesis, ameliorates interleukin 2-induced capillary leakage and reduces tumour growth in adenocarcinoma-bearing mice

1996 • 65 citations

Induction of nitric oxide synthase in the neo‐vasculature of experimental tumours in mice

1993 • 59 citations

Modulation by nitric oxide of platelet‐activating factor‐induced albumin extravasation in the conscious rat

1993 • 54 citations

Possible role of nitric oxide in 5-hydroxytryptamine-induced increase in vascular permeability in mouse skin

1994 • 47 citations

Induction of hypoxia in experimental murine tumors by the nitric oxide synthase inhibitor, NG-nitro-L-arginine.

1994 • 43 citations

Role in nitric oxide in Kupffer cell-mediated hepatoma cell cytotoxicity in vitro and ex vivo

1996 • 38 citations

Capillary Reperfusion after L-Arginine, L-NMMA, and L-NNA Treatment in Cheek Pouch Microvasculature

1995 • 34 citations

A basolateral CHIP28/MIP26-related protein (BLIP) in kidney principal cells and gastric parietal cells

1994 • 34 citations

Nitric oxide synthase inhibition irreversibly decreases perfusion in the R3230Ac rat mammary adenocarcinoma

1995 • 30 citations

The Influence of Nitric Oxide on Tumour Vascular Tone

1995 • 20 citations