Mismatch repair in correction of replication errors and processing of DNA damage

Methylation of the hMLH1 promoter correlates with lack of expression of hMLH1 in sporadic colon tumors and mismatch repair-defective human tumor cell lines.

1997 • 1,465 citations

Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients

1996 • 957 citations

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

1999 • 914 citations

Eukaryotic DNA mismatch repair

1999 • 860 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

DNA Replication Fidelity

2004 • 737 citations

Biallelic inactivation of hMLH 1 by epigenetic gene silencing, a novel mechanism causing human MSI cancers

1998 • 629 citations

The role of DNA mismatch repair in platinum drug resistance.

1996 • 607 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

Requirement for PCNA in DNA Mismatch Repair at a Step Preceding DNA Resynthesis

1996 • 569 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

1994 • 506 citations

Loss of DNA mismatch repair in acquired resistance to cisplatin.

1996 • 505 citations

MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas

1998 • 498 citations

Mammalian DNA Mismatch Repair

1999 • 451 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.

1996 • 422 citations

Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα

1998 • 405 citations

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.

1995 • 403 citations

Transformation of MutL by ATP Binding and Hydrolysis

1999 • 400 citations

Role of Postreplicative DNA Mismatch Repair in the Cytotoxic Action of Thioguanine

1996 • 394 citations

hMSH2–hMSH6 Forms a Hydrolysis-Independent Sliding Clamp on Mismatched DNA

1999 • 368 citations

hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

1996 • 363 citations

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.

1995 • 362 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

The Human Mismatch Recognition Complex hMSH2-hMSH6 Functions as a Novel Molecular Switch

1997 • 357 citations

Efficient and accurate replication in the presence of 7,8-dihydro-8-oxoguanine by DNA polymerase η

2000 • 340 citations

MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability

2000 • 323 citations

Role of DNA mismatch repair and p53 in signaling induction of apoptosis by alkylating agents

1999 • 314 citations

DNA damage tolerance, mismatch repair and genome instability

1994 • 308 citations

Cisplatin and Adriamycin Resistance Are Associated with MutLα and Mismatch Repair Deficiency in an Ovarian Tumor Cell Line

1996 • 297 citations

Functional specificity of MutL homologs in yeast: Evidence for three Mlh1-based heterocomplexes with distinct roles during meiosis in recombination and mismatch correction

1999 • 291 citations

Transcription-Coupled Repair Deficiency and Mutations in Human Mismatch Repair Genes

1996 • 289 citations

MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast

1994 • 287 citations

The Saccharomyces cerevisiae MLH 3 gene functions in MSH3-dependent suppression of frameshift mutations

1998 • 275 citations

Involvement of the Mismatch Repair System in Temozolomide-Induced Apoptosis

1998 • 275 citations

Human MLH1 deficiency predisposes to hematological malignancy and neurofibromatosis type 1.

1999 • 245 citations

Neurofibromatosis and early onset of cancers in hMLH1-deficient children.

1999 • 238 citations

The Type of DNA Glycosylase Determines the Base Excision Repair Pathway in Mammalian Cells

1999 • 236 citations

MSH2 and MSH6 Are Required for Removal of Adenine Misincorporated Opposite 8-Oxo-Guanine in S. cerevisiae

1999 • 230 citations

DNA Polymerase δ Is Required for Human Mismatch Repair in Vitro

1997 • 227 citations

Mismatch repair defects in human carcinogenesis

1996 • 227 citations

Functional Interaction of Proliferating Cell Nuclear Antigen with MSH2-MSH6 and MSH2-MSH3 Complexes

2000 • 223 citations

ATP-dependent interaction of human mismatch repair proteins and dual role of PCNA in mismatch repair

1998 • 218 citations

Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells.

1996 • 218 citations

Mismatch correction at O6-methylguanine residues in E. coli DNA

1982 • 215 citations

HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions

1999 • 212 citations

Mismatch repair deficiency associated with overexpression of the MSH3 gene

1998 • 210 citations

Recognition and Repair of Compound DNA Lesions (Base Damage and Mismatch) by Human Mismatch Repair and Excision Repair Systems

1997 • 198 citations

DNA replication fidelity.

1992 • 191 citations

Nucleotide-promoted Release of hMutSα from Heteroduplex DNA Is Consistent with an ATP-dependent Translocation Mechanism

1998 • 190 citations

Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation

1998 • 189 citations

Unmasking a killer: DNA O6-methylguanine and the cytotoxicity of methylating agents

2000 • 185 citations

Identification of hMutLβ, a Heterodimer of hMLH1 and hPMS1

1999 • 183 citations

hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damage

1999 • 181 citations

Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair

1996 • 181 citations

Products of DNA mismatch repair genes mutS and mutL are required for transcription-coupled nucleotide-excision repair of the lactose operon in Escherichia coli.

1996 • 174 citations

hMSH2 and hMSH6 play distinct roles in mismatch binding and contribute differently to the ATPase activity of hMutSalpha

1998 • 173 citations

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

1995 • 168 citations

Binding of insertion/deletion DNA mismatches by the heterodimer of yeast mismatch repair proteins MSH2 and MSH3

1996 • 163 citations

Mouse models for hereditary nonpolyposis colorectal cancer.

1998 • 162 citations

Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins

1997 • 162 citations

Msh2 status modulates both apoptosis and mutation frequency in the murine small intestine

1999 • 159 citations

Human exonuclease I interacts with the mismatch repair protein hMSH2.

1998 • 159 citations

Functional Overlap in Mismatch Repair by Human MSH3 and MSH6

1998 • 152 citations

Defective expression of the DNA mismatch repair protein, MLH1, alters G2-M cell cycle checkpoint arrest following ionizing radiation.

1998 • 150 citations

Competency in mismatch repair prohibits clonal expansion of cancer cells treated with N-methyl-N'-nitro-N-nitrosoguanidine.

1996 • 148 citations

Different mutator phenotypes in Mlh1 - versus Pms2 -deficient mice

1999 • 138 citations

Methylator resistance mediated by mismatch repair deficiency in a glioblastoma multiforme xenograft.

1997 • 132 citations

Mismatch Repair Processing of Carcinogen-DNA Adducts Triggers Apoptosis

1999 • 132 citations

Differential induction of c-Jun NH2-terminal kinase and c-Abl kinase in DNA mismatch repair-proficient and -deficient cells exposed to cisplatin.

1997 • 129 citations

Spontaneous development of drug resistance: mismatch repair and p53 defects in resistance to cisplatin in human tumor cells

2000 • 121 citations

Cytotoxic Mechanism of 6-Thioguanine: hMutSα, the Human Mismatch Binding Heterodimer, Binds to DNA Containing S⁶-Methylthioguanine

1997 • 117 citations

Discrete in vivo roles for the MutL homologs Mlh2p and Mlh3p in the removal of frameshift intermediates in budding yeast

2000 • 114 citations

DNA Mismatch Binding and Incision at Modified Guanine Bases by Extracts of Mammalian Cells: Implications for Tolerance to DNA Methylation Damage

1994 • 108 citations

Genomic instability and tolerance to alkylating agents.

1996 • 106 citations

The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA

1998 • 104 citations

Nuclear Translocation of Mismatch Repair Proteins MSH2 and MSH6 as a Response of Cells to Alkylating Agents

2000 • 103 citations

Specific Binding of Human MSH2·MSH6 Mismatch-Repair Protein Heterodimers to DNA Incorporating Thymine- or Uracil-containing UV Light Photoproducts Opposite Mismatched Bases

1999 • 102 citations

MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2

1996 • 101 citations

Dependence on RAD52 and RAD1 for anticancer drug resistance mediated by inactivation of mismatch repair genes

1999 • 98 citations

Role of MED1 (MBD4) Gene in DNA repair and human cancer

2001 • 96 citations

Differences in the spectrum of spontaneous mutations in the hprt gene between tumor cells of the microsatellite mutator phenotype

1996 • 90 citations

Functional Studies on the Candidate ATPase Domains of Saccharomyces cerevisiae MutLα

2000 • 90 citations

The role of mismatch repair in the prevention of base pair mutations in Saccharomyces cerevisiae

1998 • 88 citations

Role of DNA mismatch repair in the cytotoxicity of ionizing radiation.

1997 • 88 citations

Molecular analysis of mutations in mutator colorectal carcinoma cell lines

1995 • 86 citations

Enhancement of MSH2–MSH3-mediated mismatch recognition by the yeast MLH1–PMS1 complex

1997 • 82 citations

Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.

1997 • 80 citations

Mismatch repair, G 2 /M cell cycle arrest and lethality after DNA damage

1999 • 74 citations

Mismatch repair of cis-diamminedichloroplatinum(II)-induced DNA damage.

1985 • 74 citations

N-(2-chloroethyl)-N'-cyclohexyl-N-nitrosourea sensitivity in mismatch repair-defective human cells.

1998 • 73 citations

A role for mismatch repair in production of chromosome aberrations by methylating agents in human cells

1995 • 68 citations

Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice

1997 • 67 citations

The human MLH1 cDNA complements DNA mismatch repair defects in Mlh1-deficient mouse embryonic fibroblasts.

1999 • 66 citations

Human MutSα Specifically Binds to DNA Containing Aminofluorene and Acetylaminofluorene Adducts

1996 • 64 citations

Mismatch repair and differential sensitivity of mouse and human cells to methylating agents

1999 • 64 citations

Mutator phenotype in Msh2-deficient murine embryonic fibroblasts.

1997 • 63 citations

Identification of a Second MutL DNA Mismatch Repair Complex (hPMS1 and hMLH1) in Human Epithelial Cells

2000 • 63 citations

Sensitivity to DNA cross-linking chemotherapeutic agents in mismatch repair-defective cellsin vitro and in xenografts

2000 • 54 citations

Spectra of spontaneous mutations at the hprt locus in colorectal carcinoma cell lines defective in mismatch repair

1997 • 53 citations

Ionizing radiation-induced apoptosis via separate Pms2- and p53-dependent pathways.

2000 • 46 citations

The Effect of O6-Methylguanine DNA Adducts on the Adenosine Nucleotide Switch Functions of hMSH2-hMSH6 and hMSH2-hMSH3

2000 • 46 citations

Mismatch Repair Mutants in Yeast Are Not Defective in Transcription-Coupled DNA Repair of UV-Induced DNA Damage

1996 • 45 citations

RETRACTED: Requirement for DNA mismatch repair proteins in the transcription-coupled repair of thymine glycols in Saccharomyces cerevisiae

1998 • 44 citations

Mismatch repair deficiency is associated with resistance to DNA minor groove alkylating agents

1999 • 42 citations

Mice defective in the DNA mismatch gene PMS2 are hypersensitive to MNU induced thymic lymphoma and are partially protected by transgenic expression of human MGMT

1999 • 40 citations

Repair of Large Insertion/Deletion Heterologies in Human Nuclear Extracts Is Directed by a 5′ Single-strand Break and Is Independent of the Mismatch Repair System

1999 • 39 citations

A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.

1995 • 38 citations

Effect of hMSH6 cDNA expression on the phenotype of mismatch repair-deficient colon cancer cell line HCT15

1999 • 37 citations

The mismatch repair protein, hMLH1, mediates 5-substituted halogenated thymidine analogue cytotoxicity, DNA incorporation, and radiosensitization in human colon cancer cells.

1999 • 37 citations

Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability

1998 • 36 citations

DNA replication arrest and tolerance to DNA methylation damage

1994 • 35 citations

Characterization of Distinct Human Endometrial Carcinoma Cell Lines Deficient in Mismatch Repair That Originated from a Single Tumor

1998 • 33 citations

Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate

1998 • 31 citations

Mismatch repair is required for O6-methylguanine-induced homologous recombination in human fibroblasts

2000 • 29 citations

Correction of Large Mispaired DNA Loops by Extracts ofSaccharomyces cerevisiae

1999 • 28 citations

Properties of N-methyl-N-nitrosourea-resistant, Mex- derivatives of an SV40-immortalized human fibroblast cell line

1989 • 28 citations

Combined mismatch and nucleotide excision repair defects in a human cell line: mismatch repair processes methylation but not UV- or ionizing radiation-induced DNA damage

1999 • 25 citations

Genetic consequences of tolerance to methylation DNA damage in mammalian cells

1993 • 25 citations

Cytotoxicity and Mutagenicity of Frameshift-Inducing Agent ICR191 in Mismatch Repair-Deficient Colon Cancer Cells

2000 • 22 citations

Sister chromatid exchanges in cells defective in mismatch, post-replication and excision repair

1995 • 16 citations

P III A.8 Sensitivity to CCNU in methylation tolerant mismatch repair defective human cells

1997 • 9 citations

Multiple mutations and frameshifts are the hallmark of defective hPMS2 in pZ189-transfected human tumor cells

2000 • 9 citations