DNA Replication Fidelity

Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic Acid

1953 • 12,496 citations

DNA Repair and Mutagenesis

2006 • 4,725 citations

DNA repair and mutagenesis

1996 • 2,289 citations

Frameshift Mutations and the Genetic Code

1966 • 1,400 citations

Mutator phenotype may be required for multistage carcinogenesis.

1991 • 1,327 citations

A constant rate of spontaneous mutation in DNA-based microbes.

1991 • 1,194 citations

DNA Replication Fidelity

2000 • 980 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis

1992 • 875 citations

DNA Polymerases: Structural Diversity and Common Mechanisms

1999 • 814 citations

Mutagenesis by 8-oxoguanine: an enemy within

1993 • 805 citations

Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes

2002 • 730 citations

FIDELITY MECHANISMS IN DNA REPLICATION

1991 • 709 citations

Eukaryotic DNA Polymerases

2002 • 682 citations

Eukaryotic polymerases ι and ζ act sequentially to bypass DNA lesions

2000 • 621 citations

Crystal Structure of a Y-Family DNA Polymerase in Action

2001 • 602 citations

CONFORMATIONAL COUPLING IN DNA POLYMERASE FIDELITY

1993 • 558 citations

Fidelity of DNA Synthesis

1982 • 516 citations

EUKARYOTIC DNA POLYMERASES

1991 • 493 citations

Specialized DNA Polymerases, Cellular Survival, and the Genesis of Mutations

2002 • 441 citations

Biochemical Basis of DNA Replication Fidelity

1993 • 441 citations

An induced-fit kinetic mechanism for DNA replication fidelity: direct measurement by single-turnover kinetics

1991 • 364 citations

Initiation Of Eukaryotic DNA Replication In Vitro

1989 • 343 citations

Active Site Tightness and Substrate Fit in DNA Replication

2002 • 341 citations

Translesion DNA synthesis in eukaryotes: A one- or two-polymerase affair

2002 • 335 citations

Comparison between DNA melting thermodynamics and DNA polymerase fidelity.

1988 • 319 citations

The mutational specificity of DNA polymerase-beta during in vitro DNA synthesis. Production of frameshift, base substitution, and deletion mutations.

1985 • 317 citations

Specificity and Mechanism of Error-prone Replication by Human Immunodeficiency Virus-1 Reverse Transcriptase

1989 • 316 citations

An open and closed case for all polymerases

1999 • 310 citations

polι, a remarkably error-prone human DNA polymerase

2000 • 309 citations

Misalignment-mediated DNA synthesis errors

1990 • 306 citations

Base selection, proofreading, and mismatch repair during DNA replication in Escherichia coli.

1993 • 300 citations

Spectra of spontaneous mutations in Escherichia coli strains defective in mismatch correction: the nature of in vivo DNA replication errors.

1987 • 291 citations

Kinetic mechanism whereby DNA polymerase I (Klenow) replicates DNA with high fidelity

1988 • 278 citations

Eukaryotic DNA polymerase amino acid sequence required for 3'----5' exonuclease activity.

1991 • 277 citations

The in vitro replication of DNA containing the SV40 origin.

1990 • 268 citations

The Fidelity of Human DNA Polymerase γ with and without Exonucleolytic Proofreading and the p55 Accessory Subunit

2001 • 248 citations

Nearest Neighbor Influences on DNA Polymerase Insertion Fidelity

1989 • 247 citations

Preferential cis–syn thymine dimer bypass by DNA polymerase η occurs with biased fidelity

2004 • 241 citations

FRAMESHIFT MUTATION: DETERMINANTS OF SPECIFICITY

1990 • 238 citations

An exonucleolytic activity of human apurinic/apyrimidinic endonuclease on 3′ mispaired DNA

2002 • 236 citations

The 3′ to 5′ exonuclease activity located in the DNA polymerase delta subunit of Saccharomyces cerevisiae is required for accurate replication.

1991 • 230 citations

MEIOTIC GENE CONVERSION MUTANTS IN SACCHAROMYCES CEREVISIAE. I. ISOLATION AND CHARACTERIZATION OF pms1-1 AND pms1-2

1985 • 220 citations

Kinetic mechanism of DNA polymerase I(Klenow fragment): identification of a second conformational change and evaluation of the internal equilibrium constant

1991 • 218 citations

Uncoupling of Leading- and Lagging-Strand DNA Replication During Lesion Bypass in Vivo

2003 • 217 citations

Replication of a cis–syn thymine dimer at atomic resolution

2003 • 214 citations

Kinetic partitioning between the exonuclease and polymerase sites in DNA error correction

1991 • 208 citations

Preferential Incorporation of G Opposite Template T by the Low-Fidelity Human DNA Polymerase ι

2000 • 195 citations

Cloning and nucleotide sequence of DNA mismatch repair gene PMS1 from Saccharomyces cerevisiae: homology of PMS1 to procaryotic MutL and HexB

1989 • 193 citations

SV40 DNA replication.

1988 • 184 citations

The mutational specificity of DNA polymerases-alpha and -gamma during in vitro DNA synthesis.

1985 • 176 citations

Fidelity of replication of phage phi X174 DNA by DNA polymerase III holoenzyme: spontaneous mutation by misincorporation.

1979 • 165 citations

Structural Insights into the Origins of DNA Polymerase Fidelity

2003 • 157 citations

DNA Structure and Aspartate 276 Influence Nucleotide Binding to Human DNA Polymerase β

2001 • 151 citations

Comparison of nucleotide interactions in water, proteins, and vacuum: model for DNA polymerase fidelity.

1986 • 148 citations

The effects of dNTP pool imbalances on frameshift fidelity during DNA replication.

1992 • 142 citations

Reverse transcriptases and genomic variability: the accuracy of DNA replication is enzyme specific and sequence dependent.

1990 • 141 citations

A Reexamination of the Nucleotide Incorporation Fidelity of DNA Polymerases

2002 • 140 citations

DNA polymerase I: from crystal structure to function via genetics

1987 • 138 citations

Structure of DNA Polymerase β with the Mutagenic DNA Lesion 8-Oxodeoxyguanine Reveals Structural Insights into Its Coding Potential

2003 • 137 citations

Frameshift errors initiated by nucleotide misincorporation.

1990 • 136 citations

Studies on the mutator gene, mutT of Escherichia coli. Molecular cloning of the gene, purification of the gene product, and identification of a novel nucleoside triphosphatase.

1988 • 130 citations

Differential extension of 3′ mispairs is a major contribution to the high fidelity of calf thymus DNA polymerase-α

1989 • 129 citations

Efficiency of Correct Nucleotide Insertion Governs DNA Polymerase Fidelity

2002 • 128 citations

Error-Prone DNA Polymerases

2001 • 127 citations

DNA Damage Control by Novel DNA Polymerases: Translesion Replication and Mutagenesis

2001 • 123 citations

Yeast DNA Polymerase η Utilizes an Induced-Fit Mechanism of Nucleotide Incorporation

2001 • 123 citations

Functions of human DNA polymerases η, κ and ι suggested by their properties, including fidelity with undamaged DNA templates

2003 • 122 citations

A specific role of MutT protein: to prevent dG.dA mispairing in DNA replication.

1989 • 120 citations

Fidelity of mammalian DNA replication and replicative DNA polymerases

1991 • 119 citations

A Structural Solution for the DNA Polymerase λ-Dependent Repair of DNA Gaps with Minimal Homology

2004 • 119 citations

Insight into the Catalytic Mechanism of DNA Polymerase β: Structures of Intermediate Complexes^,

2001 • 118 citations

Use of 2-Aminopurine Fluorescence To Examine Conformational Changes during Nucleotide Incorporation by DNA Polymerase I (Klenow Fragment)

2003 • 118 citations

Carcinogen-induced frameshift mutagenesis in repetitive sequences.

1992 • 107 citations

The Frameshift Infidelity of Human DNA Polymerase λ

2003 • 105 citations

Fidelity of DNA replication catalysed in vitro on a natural DNA template by the T4 bacteriophage multi-enzyme complex

1980 • 103 citations

Recent studies of the fidelity of DNA synthesis

1988 • 98 citations

Replication of non-hydrogen bonded bases by DNA polymerases: A mechanism for steric matching

1998 • 97 citations

Fidelity of a human cell DNA replication complex.

1988 • 93 citations

Biological asymmetries and the fidelity of eukaryotic DNA replication

1992 • 93 citations

How many pols does it take to replicate nuclear DNA?

1991 • 90 citations

DNA polymerase III holoenzyme. Components, structure, and mechanism of a true replicative complex.

1991 • 90 citations

Polymerase β simulations suggest that Arg258 rotation is a slow step rather than large subdomain motions per se 1 1Edited by B. Honig

2002 • 89 citations

Structural insights into DNA polymerase β fidelity: hold tight if you want it right

1998 • 88 citations

Reexamination of induced fit as a determinant of substrate specificity in enzymic reactions

1995 • 79 citations

Structure-based interpretation of missense mutations in Y-family DNA polymerases and their implications for polymerase function and lesion bypass

2002 • 79 citations

Requirement of Watson-Crick Hydrogen Bonding for DNA Synthesis by Yeast DNA Polymerase η

2003 • 76 citations

The role of themutTgene ofEscherichia coliin maintaining replication fidelity

1997 • 76 citations

Proofreading of DNA Polymerase η-dependent Replication Errors

2001 • 74 citations

DNA precursor asymmetries, replication fidelity, and variable genome evolution

1992 • 68 citations

Streisinger Revisited: DNA Synthesis Errors Mediated by Substrate Misalignments

2000 • 67 citations

Fidelity of replication of bacteriophage X174 DNA in vitro and in Vivo

1983 • 63 citations

Molecular mechanisms of substitution mutagenesis. An experimental test of the Watson-Crick and topal-fresco models of base mispairings.

1981 • 62 citations

Exonucleolytic proofreading of leading and lagging strand DNA replication errors.

1991 • 57 citations

Escherichia coli mutT mutator effect during in vitro DNA synthesis. Enhanced A.G replicational errors.

1987 • 57 citations

N-Acetoxy-N-acetyl-2-aminofluorene-induced mutagenesis in the lacI gene of Escherichia coli

1990 • 54 citations

Hydrolysis of 3'-terminal mispairs in vitro by the 3' .fwdarw. 5' exonuclease of DNA polymerase .delta. permits subsequent extension by DNA polymerase .alpha.

1990 • 51 citations

Mechanistic aspects of DNA polymerases: Escherichia coli DNA polymerase I (Klenow fragment) as a paradigm

1990 • 49 citations

Mammalian Translesion DNA Synthesis across an Acrolein-derived Deoxyguanosine Adduct

2003 • 48 citations

The N²-Ethylguanine and the O⁶-Ethyl- and O⁶-Methylguanine Lesions in DNA: Contrasting Responses from the “Bypass” DNA Polymerase η and the Replicative DNA Polymerase α

2003 • 47 citations

In vitro evidence that UV-induced frameshift and substitution mutations at T tracts are the result of misalignment-mediated replication past a specific thymine dimer

1992 • 45 citations

Dissecting the Fidelity of Bacteriophage RB69 DNA Polymerase: Site-Specific Modulation of Fidelity by Polymerase Accessory Proteins

2002 • 39 citations

Discrimination against purine–pyrimidine mispairs in the polymerase active site of DNA polymerase I: A structural explanation

2002 • 36 citations

The Base Substitution Fidelity of DNA Polymerase β-dependent Single Nucleotide Base Excision Repair

2003 • 35 citations

Fidelity of DNA synthesis in a mammalian in vitro replication system.

1988 • 32 citations

DNA Lesion Bypass Polymerases Open Up

2001 • 25 citations

The fidelity of DNA synthesis by the catalytic subunit of yeast DNA polymerase α alone and with accessory proteins

1991 • 16 citations

Thermodynamics of A:G mismatch poly(dG) synthesis by human immunodeficiency virus 1 reverse transcriptase

1991 • 14 citations

Progress Report to the Readers of Cancer Research

1991 • 9 citations