Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells.

de la Chapelle, A.

1997 • 3,184 citations

p53-dependent apoptosis modulates the cytotoxicity of anticancer agents

1993 • 2,969 citations

Thymocyte apoptosis induced by p53-dependent and independent pathways

1993 • 2,322 citations

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

1992 • 1,877 citations

Isolation and characterization of rat and human glyceraldehyde-3-phosphate dehydrogenase cDNAs: genomic complexity and molecular evolution of the gene

1985 • 1,836 citations

Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53

1992 • 1,358 citations

Apoptotic death in epithelial cells: cleavage of DNA to 300 and/or 50 kb fragments prior to or in the absence of internucleosomal fragmentation.

1993 • 1,144 citations

Adriamycin

1974 • 1,051 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

Structural aspects of platinum anticancer drug interactions with DNA

1987 • 927 citations

Identification of a p53-dependent negative response element in the bcl-2 gene.

1994 • 747 citations

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

1984 • 398 citations

Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance.

1990 • 393 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

Mismatch Repair Deficiency in Phenotypically Normal Human Cells

1995 • 314 citations

Similar biochemical changes associated with multidrug resistance in human breast cancer cells and carcinogen-induced resistance to xenobiotics in rats.

1986 • 301 citations

The control of apoptosis and drug resistance in ovarian cancer: influence of p53 and Bcl-2.

1995 • 293 citations

Acquired cisplatin resistance in human ovarian cancer cells is associated with enhanced repair of cisplatin-DNA lesions and reduced drug accumulation.

1991 • 288 citations

Periodicity of DNA folding in higher order chromatin structures.

1990 • 275 citations

Genetic instability in human ovarian cancer cell lines.

1994 • 134 citations

Cross-resistance to diverse drugs is associated with primary cisplatin resistance in ovarian cancer cell lines.

1993 • 129 citations

A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.

1988 • 126 citations

The multidrug resistance phenotype

1988 • 92 citations

Relevance of interstrand DNA crosslinking induced by anthracyclines for their biological activity

1994 • 61 citations

Endogenous degradation of rat liver chromatin studied by agar gel electrophoresis of nuclei

1989 • 13 citations