Selective recognition of a cisplatin-DNA adduct by human mismatch repair proteins

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

Cellular responses to cisplatin. The roles of DNA-binding proteins and DNA repair.

1994 • 646 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Loss of DNA mismatch repair in acquired resistance to cisplatin.

1996 • 505 citations

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.

1996 • 422 citations

Role of Postreplicative DNA Mismatch Repair in the Cytotoxic Action of Thioguanine

1996 • 394 citations

Cellular pharmacology of cisplatin: perspectives on mechanisms of acquired resistance.

1990 • 393 citations

hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

1996 • 363 citations

Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum(II) and cis-dichloro(ethylenediamine)platinum(II)

1983 • 329 citations

DNA damage tolerance, mismatch repair and genome instability

1994 • 308 citations

Cisplatin and Adriamycin Resistance Are Associated with MutLα and Mismatch Repair Deficiency in an Ovarian Tumor Cell Line

1996 • 297 citations

Microsatellite instability, apoptosis, and loss of p53 function in drug-resistant tumor cells.

1996 • 218 citations

Analysis of Incision Sites Produced by Human Cell Extracts and Purified Proteins during Nucleotide Excision Repair of a 1,3-Intrastrand d(GpTpG)-Cisplatin Adduct

1996 • 205 citations

The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin

1996 • 198 citations

Enhanced replicative bypass of platinum-DNA adducts in cisplatin-resistant human ovarian carcinoma cell lines.

1994 • 178 citations

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

1995 • 168 citations

Relationship between platinum-DNA adduct formation and removal and cisplatin cytotoxicity in cisplatin-sensitive and -resistant human ovarian cancer cells.

1994 • 134 citations

Characterization of a DNA damage-recognition protein from mammalian cells that binds specifically to intrastrand d(GpG) and d(ApG) DNA adducts of the anticancer drug cisplatin

1990 • 133 citations

Differential human nucleotide excision repair of paired and mispaired cisplatin-DNA adducts

1997 • 128 citations

Repair synthesis by human cell extracts in DNA damaged bycis- andtrans-diamminedichloroplatinum(II)

1989 • 113 citations

An intrastrand d(GpG) platinum crosslink in duplex M13 DNA is refractory to repair by human cell extracts.

1992 • 113 citations

DNA Mismatch Binding and Incision at Modified Guanine Bases by Extracts of Mammalian Cells: Implications for Tolerance to DNA Methylation Damage

1994 • 108 citations

DNA polymerase beta bypasses in vitro a single d(GpG)-cisplatin adduct placed on codon 13 of the HRAS gene.

1995 • 108 citations

Effect of the antitumor drug cis-diamminedichloroplatinum(II) and related platinum complexes on eukaryotic DNA replication

1990 • 103 citations

Binding of human single-stranded DNA binding protein to DNA damaged by the anticancer drug cis-diamminedichloroplatinum (II).

1992 • 91 citations

A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype.

1994 • 79 citations

Selective binding to DNA base pair mismatches by proteins from human cells

1989 • 49 citations

Role of DNA replication in carrier-ligand-specific resistance to platinum compounds in L1210 cells

1991 • 46 citations

Fork-like DNA templates support bypass replication of lesions that block DNA synthesis on single-stranded templates

1996 • 46 citations

hMSH2-independent DNA Mismatch Recognition by Human Proteins

1996 • 23 citations

Disseminated testicular cancer: current chemotherapy strategies.

1989 • 11 citations