Mutator phenotype in Msh2-deficient murine embryonic fibroblasts.

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

Isolation of a transforming sequence from a human bladder carcinoma cell line

1982 • 776 citations

Cancer risk associated with germline DNA mismatch repair gene mutations

1997 • 693 citations

The role of DNA mismatch repair in platinum drug resistance.

1996 • 607 citations

Male mice defective in the DNA mismatch repair gene PMS2 exhibit abnormal chromosome synapsis in meiosis

1995 • 536 citations

GTBP, a 160-Kilodalton Protein Essential for Mismatch-binding Activity in Human Cells

1995 • 528 citations

Loss of DNA mismatch repair in acquired resistance to cisplatin.

1996 • 505 citations

On the nature of hereditable variation in cultured somatic cells

1976 • 497 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

Mutations of GTBP in Genetically Unstable Cells

1995 • 471 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.

1996 • 422 citations

MSH2 deficient mice are viable and susceptible to lymphoid tumours

1995 • 378 citations

Li-Fraumeni syndrome fibroblasts homozygous for p53 mutations are deficient in global DNA repair but exhibit normal transcription-coupled repair and enhanced UV resistance.

1995 • 351 citations

APC mutations in colorectal tumors with mismatch repair deficiency.

1996 • 329 citations

Comparison of the in vitro transforming activities of human papillomavirus types.

1988 • 303 citations

Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines.

1995 • 301 citations

Transcription-Coupled Repair Deficiency and Mutations in Human Mismatch Repair Genes

1996 • 289 citations

The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin

1996 • 198 citations

Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair

1996 • 181 citations

Binding of Mismatched Microsatellite DNA Sequences by the Human MSH2 Protein

1994 • 166 citations

Spontaneous intestinal carcinomas and skin neoplasms in Msh2-deficient mice.

1996 • 165 citations

Immortalization of rat embryo fibroblasts by the cellular p53 oncogene.

1988 • 157 citations

Inactivation of the cellular p53 gene is a common feature of Friend virus-induced erythroleukemia: relationship of inactivation to dominant transforming alleles.

1990 • 115 citations

Differential cellular expression of the human MSH2 repair enzyme in small and large intestine.

1995 • 64 citations

Loss of Heterozygosity and Base Substitution at the APRT Locus in Mismatch-Repair-Proficient and -Deficient Colorectal Carcinoma Cell Lines

1996 • 32 citations

Cloning and expression of the Xenopus and mouse Msh2 DNA mismatch repair genes

1994 • 25 citations