The Human Mismatch Recognition Complex hMSH2-hMSH6 Functions as a Novel Molecular Switch

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

1994 • 2,071 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

MISMATCH REPAIR IN REPLICATION FIDELITY, GENETIC RECOMBINATION, AND CANCER BIOLOGY

1996 • 1,485 citations

MECHANISMS AND BIOLOGICAL EFFECTS OF MISMATCH REPAIR

1991 • 876 citations

Isolation of an hMSH2-p160 Heterodimer That Restores DNA Mismatch Repair to Tumor Cells

1995 • 599 citations

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.

1996 • 576 citations

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6

1996 • 541 citations

RGS Proteins and Signaling by Heterotrimeric G Proteins

1997 • 522 citations

Strand-specific mismatch correction in nuclear extracts of human and Drosophila melanogaster cell lines.

1990 • 408 citations

Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.

1995 • 403 citations

hMutSβ, a heterodimer of hMSH2 and hMSH3, binds to insertion/deletion loops in DNA

1996 • 363 citations

Signal transduction by guanine nucleotide binding proteins

1987 • 362 citations

Heteroduplex repair in extracts of human HeLa cells

1991 • 355 citations

Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.

1986 • 353 citations

MutS mediates heteroduplex loop formation by a translocation mechanism

1997 • 325 citations

Identification of mismatch repair genes and their role in the development of cancer

1995 • 319 citations

Isolation and Characterization of the Escherichia coli mutL Gene Product

1989 • 298 citations

Methyl-directed DNA Mismatch Correction

1989 • 297 citations

MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast

1994 • 287 citations

Strand-specific Mismatch Repair in Mammalian Cells

1997 • 253 citations

Guanine nucleotide exchange factors: Activators of the Ras superfamily of proteins

1995 • 217 citations

Emerging concepts in the Ras superfamily of GTP‐binding proteins

1993 • 208 citations

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies.

1996 • 205 citations

The mismatch-repair protein hMSH2 binds selectively to DNA adducts of the anticancer drug cisplatin

1996 • 198 citations

Mutation of MSH3 in endometrial cancer and evidence for its functional role in heteroduplex repair

1996 • 181 citations

Binding of Mismatched Microsatellite DNA Sequences by the Human MSH2 Protein

1994 • 166 citations

Altering the conserved nucleotide binding motif in the Salmonella typhimurium MutS mismatch repair protein affects both its ATPase and mismatch binding activities.

1991 • 164 citations

MutS homologs in mammalian cells

1997 • 163 citations

Genetic and Biochemical Analysis of Msh2p-Msh6p: Role of ATP Hydrolysis and Msh2p-Msh6p Subunit Interactions in Mismatch Base Pair Recognition

1997 • 129 citations

Dominant negative mutator mutations in the mutS gene of Escherichia coli

1994 • 127 citations

Ras-GTPase Activating Protein (GAP): A Putative Effector for Ras

1997 • 105 citations

Purified human MSH2 protein binds to DNA containing mismatched nucleotides.

1994 • 90 citations

The purification of a human mismatch-binding protein and identification of its associated ATPase and helicase activities.

1992 • 89 citations

Identification of homologous pairing and strand-exchange activity from a human tumor cell line based on Z-DNA affinity chromatography.

1988 • 87 citations

Influence of the Kinesin Neck Domain on Dimerization and ATPase Kinetics

1997 • 76 citations

The effect of DNA mismatches on the ATPase activity of MSH1, a protein in yeast mitochondria that recognizes DNA mismatches.

1994 • 69 citations

Cell cycle regulation of the human DNA mismatch repair genes hMSH2, hMLH1, and hPMS2.

1997 • 66 citations

Differential cellular expression of the human MSH2 repair enzyme in small and large intestine.

1995 • 64 citations

Signal transduction pathways involving RAS

1994 • 63 citations

DNA mismatch repair detected in human cell extracts.

1987 • 42 citations

Interaction of MutS Protein with the Major and Minor Grooves of a Heteroduplex DNA

1997 • 41 citations

Fate of mismatched base-pair regions in polyoma heteroduplex DNA during infection of mouse cells.

1976 • 40 citations

Direct visualization of dynamics and co-operative conformational changes within RecA filaments that appear to be associated with the hydrolysis of adenosine 5′-O-(3-thiotriphosphate)

1992 • 40 citations

Replacement of Gly815 in Helicase Motif V Alters the Single-stranded DNA-dependent ATPase Activity of the Herpes Simplex Virus Type 1 Helicase-Primase

1996 • 32 citations

Messenger RNA translation in prokaryotes: GTPase centers associated with translational factors

1996 • 20 citations