A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

1943 • 3,852 citations

The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer

1993 • 2,884 citations

Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer

1993 • 2,282 citations

The 1993–94 Généthon human genetic linkage map

1994 • 1,870 citations

Mutation of a mutL Homolog in Hereditary Colon Cancer

1994 • 1,834 citations

Mutations of two P/WS homologues in hereditary nonpolyposis colon cancer

1994 • 1,544 citations

The distribution of the numbers of mutants in bacterial populations

1949 • 1,471 citations

Hypermutability and mismatch repair deficiency in RER+ tumor cells

1993 • 1,042 citations

Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation.

1994 • 506 citations

Genomic instability in repeated sequences is an early somatic event in colorectal tumorigenesis that persists after transformation

1994 • 496 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Microsatellites for linkage analysis of genetic traits

1992 • 440 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.

1994 • 332 citations

DNA damage tolerance, mismatch repair and genome instability

1994 • 308 citations

MLH1, PMS1, and MSH2 Interactions During the Initiation of DNA Mismatch Repair in Yeast

1994 • 287 citations

Increased mutation rate at the hprt locus accompanies microsatellite instability in colon cancer.

1995 • 239 citations

Dual requirement in yeast DNA mismatch repair for MLH1 and PMS1, two homologs of the bacterial mutL gene.

1994 • 222 citations

Mismatch correction at O6-methylguanine residues in E. coli DNA

1982 • 215 citations

Isolation and partial characterization of human cell mutants differing in sensitivity to killing and mutation by methylnitrosourea and N-methyl-N'-nitro-N-nitrosoguanidine.

1986 • 203 citations

Self-destruction and tolerance in resistance of mammalian cells to alkylation damage

1992 • 173 citations

Isolation and characterization of cDNA clones derived from the divergently transcribed gene in the region upstream from the human dihydrofolate reductase gene

1989 • 148 citations

Dominant negative mutator mutations in the mutS gene of Escherichia coli

1994 • 127 citations

A human 200-kDa protein binds selectively to DNA fragments containing G.T mismatches.

1988 • 126 citations

O6-Methylguanine-DNA methyltransferase of human lymphoid cells: structural and kinetic properties and absence in repair-deficient cells.

1983 • 125 citations

DNA Mismatch Binding and Incision at Modified Guanine Bases by Extracts of Mammalian Cells: Implications for Tolerance to DNA Methylation Damage

1994 • 108 citations

A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype.

1994 • 79 citations

N-Methyl-N′-nitro-N-nitrosoguanidine sensitivity of E. coli mutants deficient in DNA methylation and mismatch repair

1981 • 59 citations

Tolerance to O6-methylguanine and 6-thioguanine cytotoxic effects: a cross-resistant phenotype in N-methylnitrosourea-resistant Chinese hamster ovary cells.

1990 • 42 citations

DNA replication arrest and tolerance to DNA methylation damage

1994 • 35 citations

Tolerance to methylnitrosourea-induced DNA damage is associated with 6-thioguanine resistance in CHO cells

1989 • 35 citations

Properties of N-methyl-N-nitrosourea-resistant, Mex- derivatives of an SV40-immortalized human fibroblast cell line

1989 • 28 citations

MNNG-induced partial phenotypic reversion of Mer^- cells

1987 • 20 citations

Differences in induction of sister chromatid exchanges in MNNG-resistant Hela S3 Mer⁻cell lines

1990 • 10 citations

Molecular and cellular characterization of Mex-/methylation-resistant phenotype. Gene and cDNA cloning, serum dependence, and tumor suppression of transfectant strains.

1993 • 9 citations