Loss of DNA mismatch repair in acquired resistance to cisplatin.

New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening

1990 • 9,412 citations

MUTATIONS OF BACTERIA FROM VIRUS SENSITIVITY TO VIRUS RESISTANCE

1943 • 3,852 citations

Feasibility of a High-Flux Anticancer Drug Screen Using a Diverse Panel of Cultured Human Tumor Cell Lines

1991 • 3,158 citations

Inactivation of the mouse Msh2 gene results in mismatch repair deficiency, methylation tolerance, hyperrecombination, and predisposition to cancer

1995 • 785 citations

An alkylation-tolerant, mutator human cell line is deficient in strand-specific mismatch repair.

1993 • 445 citations

Mutator phenotypes in human colorectal carcinoma cell lines.

1994 • 428 citations

Evidence for a connection between the mismatch repair system and the G2 cell cycle checkpoint.

1995 • 362 citations

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage

1993 • 361 citations

Defective mismatch repair in extracts of colorectal and endometrial cancer cell lines exhibiting microsatellite instability.

1994 • 332 citations

Identification of mismatch repair genes and their role in the development of cancer

1995 • 319 citations

Frequent microsatellite instability in primary small cell lung cancer.

1994 • 224 citations

Differential potentiation of alkylating and platinating agent cytotoxicity in human ovarian carcinoma cells by glutathione depletion.

1985 • 195 citations

DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines.

1995 • 168 citations

Cell-mediated immunity to human malignant cells

1972 • 148 citations

Microsatellite instability and other molecular abnormalities in non-small cell lung cancer

1995 • 117 citations

DNA Mismatch Binding and Incision at Modified Guanine Bases by Extracts of Mammalian Cells: Implications for Tolerance to DNA Methylation Damage

1994 • 108 citations

Microsatellite instability in ovarian neoplasms

1995 • 103 citations

Mutagenicity and genotoxicity of the major DNA adduct of the antitumor drug cis-diamminedichloroplatinum(II)

1993 • 97 citations

Pitfalls and practice of Luria-Delbrück fluctuation analysis: a review.

1988 • 85 citations

High-Density Genetic Map of the BRCA1 Region of Chromosome 17q12-q21

1993 • 84 citations

A mismatch recognition defect in colon carcinoma confers DNA microsatellite instability and a mutator phenotype.

1994 • 79 citations

Characterization of a hydroxyurea-resistant human KB cell line with supersensitivity to 6-thioguanine.

1994 • 56 citations

Cross-resistance between cisplatin, antimony potassium tartrate, and arsenite in human tumor cells.

1995 • 51 citations

Modeling and measurement of the spontaneous mutation rate in mammalian cells

1995 • 50 citations

Multiple biological markers in germ cell tumor patients treated with platinum-based chemotherapy.

1992 • 50 citations

Microsatellite instability in human testicular germ cell tumours

1995 • 39 citations

A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.

1995 • 38 citations

DNA replication arrest and tolerance to DNA methylation damage

1994 • 35 citations

In vitro mutational specificity of cisplatin in the human hypoxanthine guanine phosphoribosyltransferase gene.

1992 • 32 citations

Mismatch binding proteins and tolerance to alkylating agents in human cells

1990 • 29 citations

Genetic consequences of tolerance to methylation DNA damage in mammalian cells

1993 • 25 citations

Mammalian cells share a common pathway for the relief of DNA replication arrest by O6-alkyl guanine, incorporated 6-thioguanine and UV photoproducts

1992 • 10 citations

Mechanisms of resistance to 6-thioguanine in a murine pancreatic tumor

1992 • 7 citations