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A Randomized Trial of Bevacizumab, an Anti–Vascular Endothelial Growth Factor Antibody, for Metastatic Renal Cancer

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1995 • 2,650 citations

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1994 • 2,460 citations

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1992 • 2,293 citations

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2000 • 2,286 citations

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1989 • 2,267 citations

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Purification and Characterization of Hypoxia-inducible Factor 1

1995 • 2,010 citations

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1991 • 1,991 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis

1993 • 1,961 citations

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

2004 • 1,935 citations

Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells

1996 • 1,908 citations

Randomized Phase II Trial Comparing Bevacizumab Plus Carboplatin and Paclitaxel With Carboplatin and Paclitaxel Alone in Previously Untreated Locally Advanced or Metastatic Non-Small-Cell Lung Cancer

2004 • 1,894 citations

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2001 • 1,874 citations

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1996 • 1,670 citations

VEGF-Trap: A VEGF blocker with potent antitumor effects

2002 • 1,641 citations

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1997 • 1,590 citations

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2000 • 1,536 citations

Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor

1992 • 1,528 citations

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2001 • 1,520 citations

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1994 • 1,460 citations

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1991 • 1,375 citations

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1996 • 1,355 citations

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1998 • 1,192 citations

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2000 • 1,159 citations

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1992 • 1,145 citations

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2002 • 1,066 citations

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1996 • 1,031 citations

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2001 • 1,012 citations

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1991 • 999 citations

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1998 • 964 citations

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2002 • 955 citations

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2001 • 902 citations

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1996 • 886 citations

MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis

2002 • 879 citations

Thalidomide and its analogs overcome drug resistance of human multiple myeloma cells to conventional therapy

2000 • 868 citations

Blockage of the vascular endothelial growth factor stress response increases the antitumor effects of ionizing radiation.

1999 • 866 citations

SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo

2003 • 860 citations

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

1996 • 855 citations

Cell Adhesion Mediated Drug Resistance (CAM-DR): Role of Integrins and Resistance to Apoptosis in Human Myeloma Cell Lines

1999 • 850 citations

PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration.

2000 • 848 citations

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1997 • 847 citations

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2003 • 846 citations

Immunomodulatory drug CC-5013 overcomes drug resistance and is well tolerated in patients with relapsed multiple myeloma

2002 • 812 citations

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2002 • 807 citations

Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability

1999 • 802 citations

Vascular Trauma Induces Rapid but Transient Mobilization of VEGFR2 ⁺ AC133 ⁺ Endothelial Precursor Cells

2001 • 802 citations

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1997 • 792 citations

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1996 • 788 citations

Randomized Study of High-Dose and Low-Dose Interleukin-2 in Patients With Metastatic Renal Cancer

2003 • 778 citations

The evolution of thalidomide and its IMiD derivatives as anticancer agents

2004 • 774 citations

Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.

1995 • 766 citations

Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium.

1993 • 764 citations

A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

2001 • 729 citations

Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice

2002 • 726 citations

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

2002 • 706 citations

Specialization of tumour vasculature

2002 • 698 citations

Vascular Endothelial Growth Factor and Angiopoietin-1 Stimulate Postnatal Hematopoiesis by Recruitment of Vasculogenic and Hematopoietic Stem Cells

2001 • 692 citations

Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

2002 • 685 citations

Identification and characterization of the blood vessels of solid tumors that are leaky to circulating macromolecules.

1988 • 680 citations

Anti-Vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions.

2000 • 676 citations

Vasculogenic Mimicry and Tumor Angiogenesis

2000 • 673 citations

Angiogenesis in acute and chronic leukemias and myelodysplastic syndromes

2000 • 662 citations

Angiogenesis-Independent Endothelial Protection of Liver: Role of VEGFR-1

2003 • 658 citations

Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood

2000 • 658 citations

Bone marrow angiogenesis and progression in multiple myeloma

1994 • 656 citations

Circulating Activated Endothelial Cells in Sickle Cell Anemia

1997 • 653 citations

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment

2002 • 638 citations

Inhibition of the insulin-like growth factor receptor-1 tyrosine kinase activity as a therapeutic strategy for multiple myeloma, other hematologic malignancies, and solid tumors

2004 • 621 citations

The Carboxyl-terminal Domain(111–165) of Vascular Endothelial Growth Factor Is Critical for Its Mitogenic Potency

1996 • 615 citations

Velcade®: U.S. FDA Approval for the Treatment of Multiple Myeloma Progressing on Prior Therapy

2003 • 591 citations

Bone Marrow Neovascularization, Plasma Cell Angiogenic Potential, and Matrix Metalloproteinase-2 Secretion Parallel Progression of Human Multiple Myeloma

1999 • 590 citations

Molecular mechanisms mediating antimyeloma activity of proteasome inhibitor PS-341

2003 • 572 citations

Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth.

1996 • 567 citations

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1993 • 564 citations

VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

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2001 • 562 citations

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2000 • 549 citations

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1997 • 546 citations

Expression of vascular endothelial growth factor and its receptors in hematopoietic malignancies.

1999 • 543 citations

VEGF145, a Secreted Vascular Endothelial Growth Factor Isoform That Binds to Extracellular Matrix

1997 • 529 citations

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1997 • 525 citations

How Tumors Become Angiogenic

1996 • 514 citations

Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans

2001 • 504 citations

Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor.

1990 • 503 citations

Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors

1996 • 497 citations

VEGF Receptor Signal Transduction

2001 • 496 citations

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1997 • 492 citations

Vascular Endothelial Growth Factor Signals Endothelial Cell Production of Nitric Oxide and Prostacyclin through Flk-1/KDR Activation of c-Src

1999 • 481 citations

Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains

1995 • 480 citations

Vascular Endothelial Growth Factor Stimulates Tyrosine Phosphorylation and Recruitment to New Focal Adhesions of Focal Adhesion Kinase and Paxillin in Endothelial Cells

1997 • 477 citations

Expression of Vascular Endothelial Growt Factor and Its Receptors fit and KDR in Ovarian Carcinoma

1995 • 469 citations

Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice

1999 • 466 citations

Evidence of increased angiogenesis in patients with acute myeloid leukemia

2000 • 465 citations

Vascular Endothelial Growth Factor, a Possible Paracrine Growth Factor in Human Acute Myeloid Leukemia

1997 • 465 citations

Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model.

2002 • 462 citations

Mutant p53 potentiates protein kinase C induction of vascular endothelial growth factor expression.

1994 • 453 citations

During angiogenesis, vascular endothelial growth factor regulate natural killer cell adhesion to tumor endothelium

1996 • 449 citations

Vascular endothelial growth factor: Crystal structure and functional mapping of the kinase domain receptor binding site

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Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues.

1992 • 443 citations

Expression and functional significance of VE-cadherin in aggressive human melanoma cells: Role in vasculogenic mimicry

2001 • 440 citations

A role for survivin in chemoresistance of endothelial cells mediated by VEGF

2002 • 438 citations

Adhesion of human myeloma-derived cell lines to bone marrow stromal cells stimulates interleukin-6 secretion

1993 • 437 citations

The Vascular Endothelial Growth Factor Receptor KDR Activates Multiple Signal Transduction Pathways in Porcine Aortic Endothelial Cells

1997 • 436 citations

Nitric Oxide Is an Upstream Signal of Vascular Endothelial Growth Factor-induced Extracellular Signal-regulated Kinase½ Activation in Postcapillary Endothelium

1998 • 436 citations

Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration

2000 • 435 citations

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

2001 • 420 citations

Angiogenesis and angiogenesis inhibition: An overview

1997 • 419 citations

A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases.

1996 • 416 citations

VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis

2002 • 372 citations

Amino acid and cDNA sequences of a vascular endothelial cell mitogen that is homologous to platelet-derived growth factor.

1990 • 368 citations

Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer.

1996 • 366 citations

Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma

2004 • 365 citations

Phosphorylation of the endothelial nitric oxide synthase at Ser‐1177 is required for VEGF‐induced endothelial cell migration

2000 • 363 citations

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1991 • 352 citations

Vascular endothelial growth factor (VEGF) directly enhances osteoclastic bone resorption and survival of mature osteoclasts

2000 • 345 citations

Both v-Ha-Ras and v-Raf Stimulate Expression of the Vascular Endothelial Growth Factor in NIH 3T3 Cells

1995 • 336 citations

The antiangiogenic property of docetaxel is synergistic with a recombinant humanized monoclonal antibody against vascular endothelial growth factor or 2-methoxyestradiol but antagonized by endothelial growth factors.

2001 • 333 citations

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1991 • 325 citations

Prognostic value of bone marrow angiogenesis in multiple myeloma.

2000 • 321 citations

Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14.

1993 • 317 citations

Lymphoma-Specific Genetic Aberrations in Microvascular Endothelial Cells in B-Cell Lymphomas

2004 • 317 citations

Vascular Endothelial Growth Factor (VEGF)-driven Actin-based Motility Is Mediated by VEGFR2 and Requires Concerted Activation of Stress-activated Protein Kinase 2 (SAPK2/p38) and Geldanamycin-sensitive Phosphorylation of Focal Adhesion Kinase

2000 • 314 citations

Phase I Study of an Immunomodulatory Thalidomide Analog, CC-4047, in Relapsed or Refractory Multiple Myeloma

2004 • 311 citations

Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation.

1995 • 311 citations

Potent VEGF blockade causes regression of coopted vessels in a model of neuroblastoma

2002 • 308 citations

MEK kinase activity is not necessary for Raf-1 function

2001 • 308 citations

Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts.

2001 • 300 citations

Platelet-derived Growth Factor Receptor β and Vascular Endothelial Growth Factor Receptor 2 Bind to the β3Integrin through Its Extracellular Domain

2000 • 289 citations

Utilization of Distinct Signaling Pathways by Receptors for Vascular Endothelial Cell Growth Factor and Other Mitogens in the Induction of Endothelial Cell Proliferation

2000 • 285 citations

Vasculotropin/Vascular Endothelial Growth Factor Induces Differentiation in Cultured Osteoblasts

1994 • 285 citations

Human Vascular Permeability Factor

1989 • 282 citations

Vascular endothelial grouth facter B, a novel growth facter for endothelial cells

1996 • 279 citations

Angiogenesis in myelodysplastic syndromes

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BCR/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1α, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin

2002 • 276 citations

Inhibition of both paracrine and autocrine VEGF/ VEGFR-2 signaling pathways is essential to induce long-term remission of xenotransplanted human leukemias

2001 • 275 citations

Expression of a hemopoietic growth factor cDNA in a factor-dependent cell line results in autonomous growth and tumorigenicity

1985 • 273 citations

A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia

2003 • 272 citations

Primary Myeloma Cells Growing in SCID-hu Mice: A Model for Studying the Biology and Treatment of Myeloma and Its Manifestations

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VEGF165 promotes survival of leukemic cells by Hsp90-mediated induction of Bcl-2 expression and apoptosis inhibition

2002 • 260 citations

Antiangiogenic agents potentiate cytotoxic cancer therapies against primary and metastatic disease.

1992 • 259 citations

Metronomic scheduling: the future of chemotherapy?

2001 • 256 citations

Bone marrow angiogenesis and mast cell density increase simultaneously with progression of human multiple myeloma

1999 • 252 citations

Vascular Endothelial Growth Factor Receptor Localization and Activation in Human Trophoblast and Choriocarcinoma Cells1

1994 • 246 citations

Lysophosphatidic Acid Induction of Vascular Endothelial Growth Factor Expression in Human Ovarian Cancer Cells

2001 • 245 citations

Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor.

2000 • 244 citations

The Role of Phosphatidylinositol 3-Kinase in Vascular Endothelial Growth Factor Signaling

1999 • 239 citations

Flk-1, a Receptor for Vascular Endothelial Growth Factor (VEGF), Is Expressed by Retinal Progenitor Cells

1996 • 239 citations

Preferential Susceptibility of Brain Tumors to the Antiangiogenic Effects of an αv Integrin Antagonist

2001 • 236 citations

Interleukin-6 undergoes transition from paracrine growth inhibitor to autocrine stimulator during human melanoma progression.

1993 • 233 citations

Vascular Endothelial Growth Factor-Induced Migration of Vascular Smooth Muscle Cells in Vitro

1999 • 226 citations

Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer

1997 • 223 citations

Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia

2000 • 217 citations

Bone Marrow in Polycythemia Vera, Chronic Myelocytic Leukemia, and Myelofibrosis Has an Increased Vascularity

2000 • 216 citations

Cilengitide targeting of alpha(v)beta(3) integrin receptor synergizes with radioimmunotherapy to increase efficacy and apoptosis in breast cancer xenografts.

2002 • 208 citations

Expression of endothelial cell-specific receptor tyrosine kinases and growth factors in human brain tumors.

1995 • 205 citations

SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes

2003 • 203 citations

v 3 and αvβ5 integrin antagonists inhibit angiogenesis in vitro

2003 • 201 citations

Placental Growth Factor (PlGF) and Its Receptor Flt‐1 (VEGFR‐1)

2002 • 200 citations

Vascular endothelial growth factor regulates angiogenesis and vascular permeability in Kaposi's sarcoma.

1996 • 190 citations

Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells

1993 • 187 citations

Inhibition of cultured cell growth by vascular endothelial cadherin (cadherin-5/VE-cadherin).

1996 • 187 citations

Vascular endothelial growth factor and basic fibroblast growth factor present in Kaposi's sarcoma (KS) are induced by inflammatory cytokines and synergize to promote vascular permeability and KS lesion development.

1998 • 186 citations

Synthesis, Antitubulin and Antimitotic Activity, and Cytotoxicity of Analogs of 2-Methoxyestradiol, an Endogenous Mammalian Metabolite of Estradiol That Inhibits Tubulin Polymerization by Binding to the Colchicine Binding Site

1995 • 185 citations

In vitro and in vivo production of vascular endothelial growth factor by chronic lymphocytic leukemia cells

2000 • 183 citations

Vascular Endothelial Growth Factor-induced Migration of Multiple Myeloma Cells Is Associated with β1 Integrin- and Phosphatidylinositol 3-Kinase-dependent PKCα Activation

2002 • 182 citations

Endothelial cells in the bone marrow of patients with multiple myeloma

2003 • 177 citations

Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts.

2002 • 169 citations

Proteasome inhibitor PS-341 abrogates IL-6 triggered signaling cascades via caspase-dependent downregulation of gp130 in multiple myeloma

2003 • 169 citations

The vascular endothelial growth factor receptor tyrosine kinase inhibitor PTK787/ZK222584 inhibits growth and migration of multiple myeloma cells in the bone marrow microenvironment

2003 • 169 citations

Evaluation and clinical correlations of bone marrow angiogenesis in myelofibrosis with myeloid metaplasia

2000 • 168 citations

Internal and external autocrine VEGF/KDR loops regulate survival of subsets of acute leukemia through distinct signaling pathways

2004 • 165 citations

AIDS-associated kaposi's sarcoma cells in culture express vascular endothelial growth factor

1992 • 164 citations

Cancer and Leukemia Group B 90206

2004 • 163 citations

Ultraviolet B and H2O2 Are Potent Inducers of Vascular Endothelial Growth Factor Expression in Cultured Keratinocytes

1996 • 159 citations

Vessel counts and vascular endothelial growth factor expression in pancreatic adenocarcinoma

1998 • 158 citations

Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma

1999 • 156 citations

Protein Kinase G Mediates Vascular Endothelial Growth Factor-induced Raf-1 Activation and Proliferation in Human Endothelial Cells

1998 • 156 citations

RANKL and Vascular Endothelial Growth Factor (VEGF) Induce Osteoclast Chemotaxis through an ERK1/2-dependent Mechanism

2003 • 152 citations

Bone marrow microvessel density is a prognostic factor for survival in patients with multiple myeloma

2000 • 151 citations

Characterization of adhesion molecules on human myeloma cell lines

1992 • 150 citations

Essential Role of Caveolae in Interleukin-6- and Insulin-like Growth Factor I-triggered Akt-1-mediated Survival of Multiple Myeloma Cells

2003 • 148 citations

Role of phospholipase C, protein kinase C, and calcium in VEGF-induced venular hyperpermeability

1999 • 147 citations

VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis

2004 • 147 citations

Rapid turnover of the platelet-derived growth factor receptor in sis-transformed cells and reversal by suramin. Implications for the mechanism of autocrine transformation.

1988 • 147 citations

Design and Discovery of Small Molecules Targeting Raf-1 Kinase

2002 • 146 citations

Expression of VEGF and its receptors by myeloma cells

2003 • 146 citations

Vascular endothelial growth factor and its receptors in normal human testicular tissue

1997 • 143 citations

Preclinical studies of the combination of angiogenic inhibitors with cytotoxic agents

1997 • 140 citations

Induction of apoptosis in human lung cancer cells after wild-type p53 activation by methoxyestradiol

1997 • 138 citations

Effects of 17 beta-estradiol metabolites on cell cycle events in MCF-7 cells.

1992 • 135 citations

Mechanisms by which SGN-40, a Humanized Anti-CD40 Antibody, Induces Cytotoxicity in Human Multiple Myeloma Cells: Clinical Implications

2004 • 134 citations

Uterine smooth muscle cells express functional receptors (flt-1 and KDR) for vascular permeability factor/vascular endothelial growth factor.

1997 • 132 citations

The Proteasome Is Involved in Angiogenesis

1998 • 131 citations

Pharmacological characterization of CP-547,632, a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor for cancer therapy.

2003 • 126 citations

Autostimulatory effects of IL-6 on excessive B cell differentiation in patients with systemic lupus erythematosus: analysis of IL-6 production and IL-6R expression

1992 • 125 citations

Anti-Vascular Endothelial Growth Factor Monoclonals in Non-Small Cell Lung Cancer

2004 • 125 citations

Ex vivo induction of multiple myeloma–specific cytotoxic T lymphocytes

2003 • 124 citations

2-Methoxyestradiol overcomes drug resistance in multiple myeloma cells

2002 • 121 citations

VRAP Is an Adaptor Protein That Binds KDR, a Receptor for Vascular Endothelial Cell Growth Factor

2000 • 120 citations

LY317615 decreases plasma VEGF levels in human tumor xenograft-bearing mice

2004 • 118 citations

Specific roles for the PI3K and the MEK–ERK pathway in IGF-1-stimulated chemotaxis, VEGF secretion and proliferation of multiple myeloma cells: study in the 5T33MM model

2004 • 114 citations

Identification of Vascular Endothelial Growth Factor Receptor-1 Tyrosine Phosphorylation Sites and Binding of SH2 Domain-containing Molecules

1998 • 112 citations

Bevacizumab in the Treatment of Breast Cancer: Rationale and Current Data

2004 • 110 citations

Vascular endothelial growth factor chimeric toxin is highly active against endothelial cells.

1999 • 107 citations

Prognostic value of angiogenesis in solitary bone plasmacytoma

2003 • 107 citations

High-Time Chemotherapy or High Time for Low Dose

2000 • 107 citations

Angiogenesis in B Cell Lymphoproliferative Diseases. Biological and Clinical Studies

1995 • 106 citations

Expression of vascular endothelial growth factor and its receptors in multiple myeloma and other hematopoietic malignancies

2001 • 105 citations

VEGF Stimulates MAPK through a Pathway That Is Unique for Receptor Tyrosine Kinases

1999 • 102 citations

Ecstasy danger hits the headlines

2002 • 101 citations

Thalidomide in multiple myeloma, myelodysplastic syndromes and histiocytosis. Analysis of clinical results and of surrogate angiogenesis markers

2001 • 99 citations

Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-δ and by mobilization of intracellular Ca2+

2001 • 98 citations

Protein Tyrosine Kinases Expressed in Glomeruli and Cultured Glomerular Cells: Flt-1 and VEGF Expression in Renal Mesangial Cells

1995 • 97 citations

Identification of a Heparin Binding Peptide on the Extracellular Domain of the KDR VEGF Receptor

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Effect of thalidomide therapy on bone marrow angiogenesis in multiple myeloma

2004 • 93 citations

Private and public autocrine loops in neoplastic cells.

1989 • 90 citations

HCPTPA, a Protein Tyrosine Phosphatase That Regulates Vascular Endothelial Growth Factor Receptor-mediated Signal Transduction and Biological Activity

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Interactions of FLT-1 and KDR with Phospholipase C γ: Identification of the Phosphotyrosine Binding Sites

1997 • 88 citations

2‐methoxyestradiol blocks cell‐cycle progression at G₂/M phase and inhibits growth of human prostate cancer cells

2001 • 88 citations

Expression of Protein Tyrosine Kinases in Islet Cells: Possible Role of the Flk-1 Receptor forβ-Cell Maturation from Duct Cells

1994 • 88 citations

The physiological estrogen metabolite 2-methoxyestradiol reduces tumor growth and induces apoptosis in human solid tumors

2001 • 87 citations

Vascular Endothelial Growth Factor Signaling Pathway as an Emerging Target in Hematologic Malignancies

2001 • 86 citations

Cilengitide (EMD 121974) arrests the growth of a heavily pretreated highly vascularised head and neck tumour

2003 • 85 citations

Heterogeneous vascular endothelial growth factor (VEGF) isoform mRNA and receptor mRNA expression in human glomeruli, and the identification of VEGF148 mRNA, a novel truncated splice variant

1999 • 85 citations

CD40 activation induces p53-dependent vascular endothelial growth factor secretion in human multiple myeloma cells

2002 • 85 citations

GW654652, the pan-inhibitor of VEGF receptors, blocks the growth and migration of multiple myeloma cells in the bone marrow microenvironment

2003 • 84 citations

Vascular endothelial growth factor and its receptors in multiple myeloma

2003 • 79 citations

New Chemotherapeutic Advances in Pancreatic, Colorectal, and Gastric Cancers

2004 • 79 citations

Effects of SU5416, a small molecule tyrosine kinase receptor inhibitor, on FLT3 expression and phosphorylation in patients with refractory acute myeloid leukemia

2004 • 78 citations

The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells

2000 • 75 citations

Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma

2001 • 73 citations

An in vitro tumor model: analysis of angiogenic factor expression after chemotherapy.

2002 • 67 citations

Antitumor activity of lysophosphatidic acid acyltransferase-beta inhibitors, a novel class of agents, in multiple myeloma.

2003 • 67 citations

A Role for Cadherin-5 in Regulation of Vascular Endothelial Growth Factor Receptor 2 Activity in Endothelial Cells

1999 • 66 citations

Tyrosine 1213 of Flt-1 Is a Major Binding Site of Nck and SHP-2

1998 • 64 citations

Vascular endothelial growth factor is a potent angiogenic factor in AIDS-associated Kaposi's sarcoma-derived spindle cells.

1997 • 63 citations

Expression of multiple β1 integrins on circulating monoclonal B cells in patients with multiple myeloma

1993 • 62 citations

Tyrosine phosphorylation of the vascular endothelial-growth-factor receptor-2 (VEGFR-2) is modulated by Rho proteins

2000 • 61 citations

Vascular endothelial growth factor-induced prostacyclin production is mediated by a protein kinase C (PKC)-dependent activation of extracellular signal-regulated protein kinases 1 and 2 involving PKC-δ and by mobilization of intracellular Ca2+

2001 • 58 citations

Vascular endothelial growth factor receptor tyrosine kinase inhibitors: PTK787/ZK 222584

2003 • 54 citations

Evidence for internal autocrine regulation of growth in acute myeloblastic leukemia cells.

1994 • 48 citations

Vascular Endothelial Growth Factor/Vascular Permeability Factor in the Pathogenesis of Primary Effusion Lymphomas

2001 • 48 citations

The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells

2000 • 45 citations

Intratumoral microvascular density in malignant lymphomas of B‐cell origin

2001 • 42 citations

Sck Interacts with KDR and Flt-1 via Its SH2 Domain

1998 • 38 citations

Comparative Expression of Novel Vascular Endothelial Growth Factor/Vascular Permeability Factor Transcripts in Skin, Papillomas, and Carcinomas of v-Ha-rasTg.AC Transgenic Mice and FVB/N Mice

1998 • 36 citations

Immunohistochemical Detection of VEGF in the Bone Marrow of Patients With Acute Myeloid Leukemia: Correlation Between VEGF Expression and the FAB Category

2003 • 35 citations

Immunohistochemical Detection of VEGF in the Bone Marrow of Patients With Chronic Myeloid Leukemia and Correlation With the Phase of Disease

2004 • 35 citations

Adhesive Interactions of Human Multiple Myeloma Cell Lines with Different Extracellular Matrix Molecules

1998 • 34 citations

Expression of VEGF Splice Variants 144/145 and 205/206 in Adult Male Tissues

1999 • 33 citations

Immunohistochemical Detection of VEGF in the Bone Marrow of Patients With Acute Myeloid Leukemia

2003 • 31 citations

Regional localization of the human c-ros-1 on 6q22 and flt on 13q12.

1987 • 30 citations

A phase I clinical and pharmacokinetic study of the Raf kinase inhibitor (RKI) BAY 43-9006 administered in combination with doxorubicin in patients with solid tumors

2003 • 28 citations

Rapid in situ cellular kinetics of intracerebral tumor angiogenesis using a monoclonal antibody to bromodeoxyuridine

1989 • 26 citations

Rapid In Situ Cellular Kinetics of Intracerebral Tumor Angiogenesis Using a Monoclonal Antibody to Bromodeoxyuridine

1989 • 21 citations

The kinase insert domain receptor gene (KDR) has been relocated to chromosome 4q11→q12

1995 • 19 citations

ZD-6474. AstraZeneca.

2003 • 18 citations

Targeted Therapy Using Novel Agents in the Treatment of Non—Small-Cell Lung Cancer

2002 • 16 citations

Involvement of Vascular Endothelial Growth Factor in Kaposi's Sarcoma Associated with Acquired Immunodeficiency Syndrome

1996 • 11 citations

Mechanism of action of thalidomide and 3-aminothalidomide in multiple myeloma

2001 • 8 citations

Deleted Work

1955 • 0 citations