MEK kinase activity is not necessary for Raf-1 function

Mechanisms of angiogenesis

1997 • 5,696 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

Distinct roles of the receptor tyrosine kinases Tie-1 and Tie-2 in blood vessel formation

1995 • 1,808 citations

Raf-1 activates MAP kinase-kinase

1992 • 1,308 citations

Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKB

1997 • 1,162 citations

Phosphorylation and Regulation of Raf by Akt (Protein Kinase B)

1999 • 1,084 citations

MAP kinase kinase kinase, MAP kinase kinase and MAP kinase

1994 • 1,005 citations

Complexes of Ras⋅GTP with Raf-1 and Mitogen-Activated Protein Kinase Kinase

1993 • 987 citations

ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK

1992 • 948 citations

Rap1 mediates sustained MAP kinase activation induced by nerve growth factor

1998 • 868 citations

Activation of the MAP kinase pathway by the protein kinase raf

1992 • 816 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

Differentiation Stage-Specific Inhibition of the Raf-MEK-ERK Pathway by Akt

1999 • 762 citations

Activation of Mitogen-Activated Protein Kinase Kinase by v-Raf in NIH 3T3 Cells and in Vitro

1992 • 691 citations

Ras recruits Raf-1 to the plasma membrane for activation by tyrosine phosphorylation.

1995 • 609 citations

VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

1999 • 563 citations

Ras signalling and apoptosis

1998 • 559 citations

Activation of extracellular signal-regulated kinase, ERK2, by p21ras oncoprotein.

1992 • 490 citations

Raf-1 protein kinase is required for growth of induced NIH/3T3 cells

1991 • 489 citations

Serine and tyrosine phosphorylations cooperate in Raf-1, but not B-Raf activation

1999 • 456 citations

Differential Regulation of Raf-1, A-Raf, and B-Raf by Oncogenic Ras and Tyrosine Kinases

1997 • 446 citations

Requirement of Ras-GTP-Raf Complexes for Activation of Raf-1 by Protein Kinase C

1998 • 437 citations

Conditional transformation of cells and rapid activation of the mitogen-activated protein kinase cascade by an estradiol-dependent human raf-1 protein kinase.

1993 • 348 citations

KSR, a novel protein kinase required for RAS signal transduction

1995 • 335 citations

The C. elegans ksr-1 gene encodes a novel raf-related kinase involved in Ras-mediated signal transduction

1995 • 312 citations

Embryonic lethality and fetal liver apoptosis in mice lacking the c-raf-1 gene

2001 • 311 citations

The ksr-1 gene encodes a novel protein kinase involved in Ras-mediated signaling in C. elegans

1995 • 306 citations

Raf exists in a native heterocomplex with hsp90 and p50 that can be reconstituted in a cell-free system.

1993 • 302 citations

Endothelial apoptosis in Braf-deficient mice

1997 • 291 citations

The native structure of the activated Raf protein kinase is a membrane-bound multi-subunit complex.

1994 • 261 citations

Reconstitution of the Raf-1-MEK-ERK signal transduction pathway in vitro.

1993 • 251 citations

Control of the ERK MAP kinase cascade by Ras and Raf.

1996 • 249 citations

Mitogen-activated protein kinase/extracellular signal-regulated protein kinase activation by oncogenes, serum, and 12-O-tetradecanoylphorbol-13-acetate requires Raf and is necessary for transformation.

1994 • 237 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation.

1995 • 231 citations

Conditionally Oncogenic Forms of the A-Raf and B-Raf Protein Kinases Display Different Biological and Biochemical Properties in NIH 3T3 Cells

1995 • 222 citations

Kinase Suppressor of Ras Forms a Multiprotein Signaling Complex and Modulates MEK Localization

1999 • 214 citations

Disruption of thetalin gene arrests mouse development at the gastrulation stage

2000 • 208 citations

Reversal of Raf-1 Activation by Purified and Membrane-Associated Protein Phosphatases

1995 • 202 citations

Phosphorylation of Raf-1 Serine 338-Serine 339 Is an Essential Regulatory Event for Ras-Dependent Activation and Biological Signaling

1997 • 196 citations

Regulation of the MAP kinase pathway by mammalian Ksr through direct interaction with MEK and ERK

1998 • 196 citations

Vascular endothelial cell lineage-specific promoter in transgenic mice

1995 • 196 citations

Expression of raf family proto-oncogenes in normal mouse tissues.

1990 • 194 citations

The Survival Function of the Bcr-Abl Oncogene Is Mediated by Bad-Dependent and -Independent Pathways: Roles for Phosphatidylinositol 3-Kinase and Raf

2000 • 188 citations

Activated MEK Stimulates Expression of AP-1 Components Independently of Phosphatidylinositol 3-Kinase (PI3-Kinase) but Requires a PI3-Kinase Signal To Stimulate DNA Synthesis

1999 • 186 citations

The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction.

1993 • 177 citations

Induction of Cell Proliferation in Quiescent NIH 3T3 Cells by Oncogenic c-Raf-1

1997 • 168 citations

A dominant-negative mutant of raf blocks mitogen-activated protein kinase activation by growth factors and oncogenic p21ras.

1993 • 161 citations

The Mouse B-raf Gene Encodes Multiple Protein Isoforms with Tissue-specific Expression

1995 • 161 citations

Post-natal lethality and neurological and gastrointestinal defects in mice with targeted disruption of the A-Raf protein kinase gene

1996 • 156 citations

Murine Ksr interacts with MEK and inhibits Ras-induced transformation

1998 • 151 citations

The mitogen-activated protein kinase cascade is activated by B-Raf in response to nerve growth factor through interaction with p21ras.

1994 • 141 citations

Activation of c-Raf-1 by Ras and Src through different mechanisms: activationin vivoandin vitro

1997 • 140 citations

Ras-Induced Activation of Raf-1 Is Dependent on Tyrosine Phosphorylation

1996 • 131 citations

Differential Raf requirement for activation of mitogen-activated protein kinase by growth factors, phorbol esters, and calcium.

1994 • 130 citations

Overlapping and specific functions of Braf and Craf-1 proto-oncogenes during mouse embryogenesis

2000 • 116 citations

Craf-1 protein kinase is essential for mouse development

1998 • 116 citations

Biochemical Analysis of MEK Activation in NIH3T3 Fibroblasts

1995 • 111 citations

Modulation of Kinase Activity and Oncogenic Properties by Alternative Splicing Reveals a Novel Regulatory Mechanism for B-Raf

1998 • 102 citations

Specific association of activated MAP kinase kinase kinase (Raf) with the plasma membranes of ras-transformed retinal cells.

1993 • 98 citations

Genetics of signal transduction in invertebrates

1994 • 96 citations

Raf, but Not MEK or ERK, Is Sufficient for Differentiation of Hippocampal Neuronal Cells

1996 • 89 citations

Conditional Transformation of Cells and Rapid Activation of the Mitogen-Activated Protein Kinase Cascade by An Estradiol-Dependent Human Raf-1 Protein Kinase

1993 • 86 citations

Activation of the Raf/MAP kinase cascade by the Ras-related protein TC21 is required for the TC21-mediated transformation of NIH 3T3 cells

1999 • 77 citations

Oncogenes, growth factors and phorbol esters regulate Raf-1 through common mechanisms

1998 • 73 citations

Association of MEK1 with p21ras.GMPPNP is dependent on B-Raf.

1994 • 73 citations

Abrogation of c-Raf expression induces apoptosis in tumor cells

1998 • 69 citations

Partial purification of a mitogen-activated protein kinase kinase activator from bovine brain. Identification as B-Raf or a B-Raf-associated activity.

1994 • 66 citations

Isoform-Specific Localization of A-RAF in Mitochondria

2000 • 63 citations

Reconstitution of the Raf-1-MEK-ERK Signal Transduction Pathway In Vitro

1993 • 51 citations

Signal transduction and cell fate specification during Caenorhabditis elegans vulval development

1994 • 51 citations

Dependence of SV40 large T-antigen cell cycle regulation on T-antigen expression levels.

1992 • 40 citations

Identification of a latent MAP kinase kinase kinase in PC12 cells as B‐raf

1994 • 37 citations

Expression of raf family proto-oncogenes in normal mouse tissues.

1990 • 37 citations

Expression of the A-raf proto-oncogene in the normal adult and embryonic mouse.

2000 • 36 citations

The Ankyrin Repeat-containing Adaptor Protein Tvl-1 Is a Novel Substrate and Regulator of Raf-1

1999 • 35 citations

The Mitogen-Activated Protein Kinase Cascade Is Activated by B-Raf in Response to Nerve Growth Factor through Interaction with p21^ras

1994 • 22 citations

Association of MEK1 with p21^ras GMPPNP Is Dependent on B-Raf

1994 • 13 citations