Specialization of tumour vasculature

The Hallmarks of Cancer

2000 • 27,569 citations

Angiogenesis in cancer and other diseases

2000 • 8,734 citations

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

1996 • 6,878 citations

Integrin Signaling

1999 • 3,705 citations

Requirement of Vascular Integrin α _v β ₃ for Angiogenesis

1994 • 3,016 citations

Vessel Cooption, Regression, and Growth in Tumors Mediated by Angiopoietins and VEGF

1999 • 2,176 citations

Cancer Treatment by Targeted Drug Delivery to Tumor Vasculature in a Mouse Model

1998 • 2,040 citations

Vascular Channel Formation by Human Melanoma Cells in Vivo and in Vitro: Vasculogenic Mimicry

1999 • 1,921 citations

Genes Expressed in Human Tumor Endothelium

2000 • 1,838 citations

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

2001 • 1,707 citations

Openings between Defective Endothelial Cells Explain Tumor Vessel Leakiness

2000 • 1,627 citations

Definition of Two Angiogenic Pathways by Distinct α _v Integrins

1995 • 1,333 citations

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

2001 • 1,217 citations

Lack of Pericytes Leads to Endothelial Hyperplasia and Abnormal Vascular Morphogenesis

2001 • 1,067 citations

Angiosarcomas Express Mixed Endothelial Phenotypes of Blood and Lymphatic Capillaries

1999 • 1,060 citations

Clinical applications of angiogenic growth factors and their inhibitors

1999 • 1,017 citations

Vascular endothelial growth factor-C-mediated lymphangiogenesis promotes tumour metastasis

2001 • 957 citations

Anti-cancer activity of targeted pro-apoptotic peptides

1999 • 904 citations

Aminopeptidase N is a receptor for tumor-homing peptides and a target for inhibiting angiogenesis.

2000 • 853 citations

Detection of tumor angiogenesis in vivo by αvβ3-targeted magnetic resonance imaging

1998 • 851 citations

Antiintegrin alpha v beta 3 blocks human breast cancer growth and angiogenesis in human skin.

1995 • 840 citations

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

2001 • 816 citations

Regulation of angiogenesis via vascular endothelial growth factor receptors.

2000 • 749 citations

The Adaptor Protein Shc Couples a Class of Integrins to the Control of Cell Cycle Progression

1996 • 739 citations

Symmetrical Mutant Phenotypes of the Receptor EphB4 and Its Specific Transmembrane Ligand ephrin-B2 in Cardiovascular Development

1999 • 708 citations

Embryonic mesodermal defects in α5 integrin-deficient mice

1993 • 694 citations

Vasculogenic Mimicry and Tumor Angiogenesis

2000 • 673 citations

Mosaic blood vessels in tumors: Frequency of cancer cells in contact with flowing blood

2000 • 658 citations

The role of αv integrins during angiogenesis: insights into potential mechanisms of action and clinical development

1999 • 651 citations

Extensive Vasculogenesis, Angiogenesis, and Organogenesis Precede Lethality in Mice Lacking All αv Integrins

1998 • 649 citations

Regulation of Angiogenesis in Vivo by Ligation of Integrin α5β1 with the Central Cell-Binding Domain of Fibronectin

2000 • 622 citations

Enhanced pathological angiogenesis in mice lacking β3 integrin or β3 and β5 integrins

2002 • 604 citations

Role of αvβ3 integrin in the activation of vascular endothelial growth factor receptor-2

1999 • 597 citations

NG2 proteoglycan is expressed exclusively by mural cells during vascular morphogenesis

2001 • 554 citations

VEGFR-3 and Its Ligand VEGF-C Are Associated with Angiogenesis in Breast Cancer

1999 • 550 citations

In situ detection of tissue factor in vascular endothelial cells: Correlation with the malignant phenotype of human breast disease

1996 • 544 citations

Apoptosis of adherent cells by recruitment of caspase-8 to unligated integrins

2001 • 544 citations

Angiogenesis promoted by vascular endothelial growth factor: Regulation through α₁β₁and α₂β₁ integrins

1997 • 516 citations

Up-regulation of vascular endothelial growth factor and its cognate receptors in a rat glioma model of tumor angiogenesis.

1993 • 502 citations

Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation.

2000 • 466 citations

A Mechanism for Modulation of Cellular Responses to VEGF Activation of the Integrins

2000 • 441 citations

Inhibition of tumor angiogenesis as a strategy to circumvent acquired resistance to anti‐cancer therapeutic agents

1991 • 441 citations

Expression and functional significance of VE-cadherin in aggressive human melanoma cells: Role in vasculogenic mimicry

2001 • 440 citations

LYVE-1 is not restricted to the lymph vessels: expression in normal liver blood sinusoids and down-regulation in human liver cancer and cirrhosis.

2001 • 439 citations

Cell surface tumor endothelial markers are conserved in mice and humans.

2001 • 414 citations

Enhancement of tumor necrosis factor α antitumor immunotherapeutic properties by targeted delivery to aminopeptidase N (CD13)

2000 • 408 citations

Elevated matrix metalloprotease and angiostatin levels in integrin α1 knockout mice cause reduced tumor vascularization

2000 • 388 citations

The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization

2000 • 379 citations

Role of B61, the Ligand for the Eck Receptor Tyrosine Kinase, in TNF-α-Induced Angiogenesis

1995 • 368 citations

Lymphangiogenesis and tumor metastasis: myth or reality?

2001 • 364 citations

Ephrin-B2 Selectively Marks Arterial Vessels and Neovascularization Sites in the Adult, with Expression in Both Endothelial and Smooth-Muscle Cells

2001 • 362 citations

Cooperative interactions of laminin 5 gamma2 chain, matrix metalloproteinase-2, and membrane type-1-matrix/metalloproteinase are required for mimicry of embryonic vasculogenesis by aggressive melanoma.

2001 • 359 citations

LYVE-1, the lymphatic system and tumor lymphangiogenesis

2001 • 348 citations

CD13/APN is activated by angiogenic signals and is essential for capillary tube formation

2001 • 311 citations

Expression of EphrinB2 Identifies a Stable Genetic Difference Between Arterial and Venous Vascular Smooth Muscle as Well as Endothelial Cells, and Marks Subsets of Microvessels at Sites of Adult Neovascularization

2001 • 308 citations

The fibronectin isoform containing the ed‐b oncofetal domain: A marker of angiogenesis

1994 • 306 citations

Platelet-derived Growth Factor Receptor β and Vascular Endothelial Growth Factor Receptor 2 Bind to the β3Integrin through Its Extracellular Domain

2000 • 289 citations

Delivery of molecular and cellular medicine to solid tumors

1997 • 268 citations

Disruption of matrix metalloproteinase 2 binding to integrin alpha vbeta 3 by an organic molecule inhibits angiogenesis and tumor growth in vivo

2000 • 264 citations

Trophoblast pseudo-vasculogenesis: faking it with endothelial adhesion receptors

1998 • 246 citations

A Signaling Pathway from the α5β1 and αvβ3 Integrins That Elevatesbcl-2 Transcription

2001 • 241 citations

Molecular regulation of tumor cell vasculogenic mimicry by tyrosine phosphorylation: role of epithelial cell kinase (Eck/EphA2).

2001 • 240 citations

Expression of the high molecular weight melanoma-associated antigen by pericytes during angiogenesis in tumors and in healing wounds.

1990 • 226 citations

Targeted delivery of tissue factor to the ED-B domain of fibronectin, a marker of angiogenesis, mediates the infarction of solid tumors in mice.

2001 • 223 citations

A fibronectin fragment inhibits tumor growth, angiogenesis, and metastasis

2001 • 215 citations

Vasculogenic Mimicry: How Convincing, How Novel, and How Significant?

2000 • 186 citations

NG2 proteoglycan-binding peptides target tumor neovasculature.

1999 • 168 citations

Functional activation of integrin ?v?3 in tumor cells expressing membrane-type 1 matrix metalloproteinase

2000 • 156 citations

RGD-Tachyplesin inhibits tumor growth.

2001 • 155 citations

Targeting tumor vasculature with homing peptides from phage display

2000 • 154 citations

Solution Structures and Integrin Binding Activities of an RGD Peptide with Two Isomers

2001 • 149 citations

Integrins alpha(v)beta3 and alpha(v)beta5 are expressed by endothelium of high-risk neuroblastoma and their inhibition is associated with increased endogenous ceramide.

2000 • 145 citations

Human endothelial cells express integrin receptors on the luminal aspect of their membrane

1992 • 131 citations

Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer

2001 • 108 citations

Correlation of chondroitin sulfate proteoglycan expression on proliferating brain capillary endothelial cells with the malignant phenotype of astroglial cells.

1991 • 105 citations

Lack of specificity of endoglin expression for tumor blood vessels

2001 • 60 citations

A Novel Approach for the Identification of Unique Tumor Vasculature Binding Peptides Using an E. coli Peptide Display Library

2000 • 54 citations

A strategy for antitumor vascular therapy by targeting the vascular endothelial growth factor: receptor complex.

2001 • 54 citations

Expression of Antisense to Integrin Subunit β3Inhibits Microvascular Endothelial Cell Capillary Tube Formation in Fibrin

2000 • 35 citations

Anatomic distribution of intraprostatic lymphatics: Implications for the lymphatic spread of prostate cancer?A preliminary study

2000 • 29 citations

Labeling and distribution of linear peptides identified using in vivo phage display selection for tumors

2000 • 25 citations