Proteasome inhibitor PS-341 inhibits human myeloma cell growth in vivo and prolongs survival in a murine model.

Tumor Angiogenesis and Metastasis — Correlation in Invasive Breast Carcinoma

1991 • 5,657 citations

STRUCTURE AND FUNCTIONS OF THE 20S AND 26S PROTEASOMES

1996 • 2,408 citations

The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.

2001 • 1,520 citations

Proteasome inhibitors: a novel class of potent and effective antitumor agents.

1999 • 1,447 citations

How Proteolysis Drives the Cell Cycle

1996 • 1,277 citations

NF-κB as a Therapeutic Target in Multiple Myeloma

2002 • 906 citations

Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition.

2001 • 544 citations

The Proteasome, a Novel Protease Regulated by Multiple Mechanisms

1999 • 540 citations

Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma.

2001 • 481 citations

The ubiquitin‐proteasome pathway and proteasome inhibitors

2001 • 428 citations

Vascular endothelial growth factor triggers signaling cascades mediating multiple myeloma cell growth and migration

2001 • 420 citations

Distinct 19 S and 20 S subcomplexes of the 26 S proteasome and their distribution in the nucleus and the cytoplasm.

1994 • 395 citations

The role of the ubiquitin-proteasome pathway in apoptosis

1999 • 382 citations

Biologic sequelae of nuclear factor–κB blockade in multiple myeloma: therapeutic applications

2002 • 382 citations

The proteasome pathway is required for cytokine-induced endothelial-leukocyte adhesion molecule expression

1995 • 354 citations

Proteasome Inhibition Measurements: Clinical Application

2000 • 308 citations

Catalytic Activities of the 20 S Proteasome, a Multicatalytic Proteinase Complex

2000 • 301 citations

Tumor growth inhibition induced in a murine model of human Burkitt's lymphoma by a proteasome inhibitor.

1998 • 277 citations

Dynamics of proteasome distribution in living cells

1997 • 269 citations

26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer

2001 • 263 citations

Proteasome inhibitors as potential novel anticancer agents

1999 • 157 citations

Proteasome inhibitor PS-341, a potential therapeutic agent for adult T-cell leukemia.

2002 • 145 citations

The Proteasome Is Involved in Angiogenesis

1998 • 131 citations

Regulation of transcription factors by protein degradation

2000 • 99 citations

S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice.

2002 • 90 citations

The specificity of proteasomes: impact on MHC class I processing and presentation of antigens

1999 • 76 citations

Proteasome inhibitors: fromin vitro uses to clinical trials

2000 • 39 citations