VEGF-receptor signal transduction

Hypoxia — a key regulatory factor in tumour growth

2002 • 4,942 citations

Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice

1995 • 3,977 citations

Activation of Vascular Endothelial Growth Factor Gene Transcription by Hypoxia-Inducible Factor 1

1996 • 3,851 citations

Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia

2003 • 3,707 citations

Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation

1999 • 3,529 citations

Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis

2000 • 2,700 citations

Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium

1995 • 2,650 citations

Regulation of endothelium-derived nitric oxide production by the protein kinase Akt

1999 • 2,577 citations

Neuropilin-1 Is Expressed by Endothelial and Tumor Cells as an Isoform-Specific Receptor for Vascular Endothelial Growth Factor

1998 • 2,440 citations

Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway

1998 • 1,963 citations

Impaired recruitment of bone-marrow–derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth

2001 • 1,874 citations

Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis

2001 • 1,707 citations

Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor.

1994 • 1,661 citations

Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1

1996 • 1,355 citations

Targeted Deficiency or Cytosolic Truncation of the VE-cadherin Gene in Mice Impairs VEGF-Mediated Endothelial Survival and Angiogenesis

1999 • 1,291 citations

VEGF-D promotes the metastatic spread of tumor cells via the lymphatics

2001 • 1,217 citations

Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice

1998 • 1,077 citations

Effects of Angiogenesis Inhibitors on Multistage Carcinogenesis in Mice

1999 • 990 citations

Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics

2002 • 939 citations

Cardiovascular Failure in Mouse Embryos Deficient in VEGF Receptor-3

1998 • 876 citations

The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities

1996 • 855 citations

p38 MAP kinase activation by vascular endothelial growth factor mediates actin reorganization and cell migration in human endothelial cells

1997 • 847 citations

A requirement for neuropilin-1 in embryonic vessel formation

1999 • 830 citations

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

2001 • 816 citations

Selective Requirement for Src Kinases during VEGF-Induced Angiogenesis and Vascular Permeability

1999 • 802 citations

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3

2001 • 759 citations

A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

2001 • 729 citations

Molecular mechanisms of lymphangiogenesis in health and disease

2002 • 709 citations

VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism

2002 • 706 citations

Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells

1998 • 695 citations

Vascular and haematopoietic stem cells: novel targets for anti-angiogenesis therapy?

2002 • 685 citations

Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188

1999 • 681 citations

Angiogenesis-Independent Endothelial Protection of Liver: Role of VEGFR-1

2003 • 658 citations

A highly conserved vascular permeability factor secreted by a variety of human and rodent tumor cell lines.

1986 • 641 citations

Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1+ stem cells from bone-marrow microenvironment

2002 • 638 citations

Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications

2002 • 636 citations

Abnormal lymphatic vessel development in neuropilin 2 mutant mice

2002 • 619 citations

VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells

1999 • 563 citations

Vascular Permeability Factor/Vascular Endothelial Growth Factor Induces Lymphangiogenesis as well as Angiogenesis

2002 • 552 citations

Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: Therapeutic implications

2002 • 535 citations

Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling

2002 • 512 citations

Flt-1, vascular endothelial growth factor receptor 1, is a novel cell surface marker for the lineage of monocyte-macrophages in humans

2001 • 504 citations

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

1992 • 495 citations

Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice

1999 • 466 citations

Neovasculature induced by vascular endothelial growth factor is fenestrated.

1997 • 441 citations

Vascular Endothelial Growth Factor Can Substitute for Macrophage Colony-Stimulating Factor in the Support of Osteoclastic Bone Resorption

1999 • 438 citations

Vascular Growth Factors and Lymphangiogenesis

2002 • 412 citations

A Vascular Endothelial Growth Factor Antagonist Is Produced by the Human Placenta and Released into the Maternal Circulation1

1998 • 408 citations

The Neuropilins Multifunctional Semaphorin and VEGF Receptors that Modulate Axon Guidance and Angiogenesis

2002 • 348 citations

Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis.

2001 • 345 citations

Expression of the vascular endothelial growth factor (VEGF) receptor gene, KDR, in hematopoietic cells and inhibitory effect of VEGF on apoptotic cell death caused by ionizing radiation.

1995 • 311 citations

Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus

1994 • 310 citations

Vascular Permeability Factor (VPF)/Vascular Endothelial Growth Factor (VEGF) Receptor-1 Down-modulates VPF/VEGF Receptor-2-mediated Endothelial Cell Proliferation, but Not Migration, through Phosphatidylinositol 3-Kinase-dependent Pathways

2001 • 301 citations

The ins and outs of APC and β‐catenin nuclear transport

2002 • 278 citations

Sphingosine Kinase Mediates Vascular Endothelial Growth Factor-Induced Activation of Ras and Mitogen-Activated Protein Kinases

2002 • 275 citations

Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites

2003 • 272 citations

Vascular Endothelial Growth Factor Induction of the Angiogenic Phenotype Requires Ras Activation

2001 • 261 citations

Receptor Chimeras Indicate That the Vascular Endothelial Growth Factor Receptor-1 (VEGFR-1) Modulates Mitogenic Activity of VEGFR-2 in Endothelial Cells

2000 • 236 citations

Lymphatic endothelium: a new frontier of metastasis research

2002 • 229 citations

Placental Growth Factor (PlGF) and Its Receptor Flt‐1 (VEGFR‐1)

2002 • 200 citations

Pathways of Macromolecular Extravasation Across Microvascular Endothelium in Response to VPF/VEGF and Other Vasoactive Mediators

1999 • 180 citations

The FLT4 gene encodes a transmembrane tyrosine kinase related to the vascular endothelial growth factor receptor.

1993 • 164 citations

Signalling properties of FLT4, a proteolytically processed receptor tyrosine kinase related to two VEGF receptors.

1994 • 163 citations

VEGFR‐3 in adult angiogenesis

2001 • 159 citations

Expression of Vascular Endothelial Growth Factor Receptors 1, 2, and 3 in Quiescent Endothelia

2002 • 157 citations

VEGF-C signaling pathways through VEGFR-2 and VEGFR-3 in vasculoangiogenesis and hematopoiesis

2000 • 155 citations

Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers

2001 • 146 citations

The Phosphorylated 1169-Tyrosine Containing Region of Flt-1 Kinase (VEGFR-1) Is a Major Binding Site for PLCγ

1997 • 124 citations

VEGF-Induced Activation of Phosphoinositide 3-Kinase Is Dependent on Focal Adhesion Kinase

2001 • 123 citations

VEGF‐induced paracellular permeability in cultured endothelial cells involves urokinase and its receptor

2003 • 120 citations

VRAP Is an Adaptor Protein That Binds KDR, a Receptor for Vascular Endothelial Cell Growth Factor

2000 • 120 citations

Small GTP-Binding Protein Rac Is an Essential Mediator of Vascular Endothelial Growth Factor-Induced Endothelial Fenestrations and Vascular Permeability

2003 • 119 citations

Overexpression of VEGF in Testis and Epididymis Causes Infertility in Transgenic Mice: Evidence for Nonendothelial Targets for VEGF

1998 • 116 citations

Identification of Vascular Endothelial Growth Factor Receptor-1 Tyrosine Phosphorylation Sites and Binding of SH2 Domain-containing Molecules

1998 • 112 citations

Two human FLT4 receptor tyrosine kinase isoforms with distinct carboxy terminal tails are produced by alternative processing of primary transcripts.

1993 • 110 citations

Lymphatic endothelial regulation, lymphoedema, and lymph node metastasis

2002 • 80 citations

The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells

2000 • 75 citations

Modulation of VEGFR-2–mediated endothelial-cell activity by VEGF-C/VEGFR-3

2003 • 61 citations

Insights into the Molecular Pathogenesis and Targeted Treatment of Lymphedema

2002 • 61 citations

The Shc-related adaptor protein, Sck, forms a complex with the vascular-endothelial-growth-factor receptor KDR in transfected cells

2000 • 45 citations

HERV-K-T47D-Related Long Terminal Repeats Mediate Polyadenylation of Cellular Transcripts

2000 • 41 citations

Vascular endothelial growth factor gene regulation and action in diabetic retinopathy

2002 • 36 citations