ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2

Short-Term Effects of Nose-Only Cigarette Smoke Exposure on Glutathione Redox Homeostasis, Cytochrome P450 1A1/2 and Respiratory Enzyme Activities in Mice Tissues

2013 • 47,043 citations

Electrospray Ionization for Mass Spectrometry of Large Biomolecules

1989 • 7,324 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Congenital Jaundice in Rats with a Mutation in a Multidrug Resistance-Associated Protein Gene

1996 • 827 citations

cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats

1996 • 641 citations

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

1994 • 635 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

Tissue distribution of the multidrug resistance protein.

1996 • 473 citations

A human canalicular multispecific organic anion transporter (cMOAT) gene is overexpressed in cisplatin-resistant human cancer cell lines with decreased drug accumulation.

1996 • 473 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

1994 • 435 citations

Hepatobiliary secretion of organic compounds; molecular mechanisms of membrane transport

1995 • 385 citations

Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome

1996 • 372 citations

Hereditary Chronic Conjugated Hyperbilirubinemia in Mutant Rats Caused by Defective Hepatic Anion Transport

1985 • 352 citations

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

1990 • 299 citations

Expression and localization of the conjugate export pump encoded by the MRP2 (cMRP/cMOAJ) gene in liver

1997 • 269 citations

ATP-dependent 17β-Estradiol 17-(β-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP)

1996 • 265 citations

The excretion of bilirubin as a diglucuronide giving the direct van den Bergh reaction

1957 • 256 citations

Investigation of the substrate specificity of a cloned expressed human bilirubin UDP-glucuronosyltransferase: UDP-sugar specificity and involvement in steroid and xenobiotic glucuronidation

1994 • 239 citations

Specificity of human UDP-Glucuronosyltransferases and xenobiotic glucuronidation

1995 • 220 citations

Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system.

1991 • 203 citations

Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies.

1994 • 196 citations

Analysis of bilirubin and bilirubin mono- and di-conjugates. Determination of their relative amounts in biological samples

1980 • 181 citations

ATP-dependent transport of taurocholate across the hepatocyte canalicular membrane mediated by a 110-kDa glycoprotein binding ATP and bile salt.

1991 • 176 citations

Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver

1994 • 165 citations

Characterization of the ATP‐dependent leukotriene C₄ export carrier in mastocytoma cells

1994 • 157 citations

Biliary excretion of bile acid conjugates in a hyperbilirubinemic mutant sprague-dawley rat

1991 • 154 citations

THE IDENTIFICATION OF “DIRECT-REACTING” BILIRUBIN AS BILIRUBIN GLUCURONIDE

1957 • 143 citations

Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion

1987 • 143 citations

Separate transport systems for biliary secretion of sulfated and unsulfated bile acids in the rat.

1988 • 142 citations

Selective hepatobiliary transport defect for organic anions and neutral steroids in mutant rats with hereditary-conjugated hyperbilirubinemia

1987 • 140 citations

ATP-dependent taurocholate transport by rat liver canalicular membrane vesicles*1, *2

1991 • 136 citations

Comparison in different species of biliary bilirubin-IX α conjugates with the activities of hepatic and renal bilirubin-IX α-uridine diphosphate glycosyltransferases

1977 • 130 citations

Differential inhibition by cyclosporins of primary‐active ATP‐dependent transporters in the hepatocyte canalicular membrane

1993 • 128 citations

The canalicular conjugate export pump encoded by the cmrp/cmoat gene.

1996 • 92 citations

Two distinct mechanisms for bilirubin glucuronide transport by rat bile canalicular membrane vesicles. Demonstration of defective ATP-dependent transport in rats (TR-) with inherited conjugated hyperbilirubinemia.

1992 • 89 citations

The Liver: Biology and Pathobiology

2002 • 87 citations

The isolation and characterization of bilirubin diglucuronide, the major bilirubin conjugate in dog and human bile

1976 • 80 citations

ATP-dependent organic anion transport system in normal and TR- rat liver canalicular membranes

1992 • 65 citations

ATP‐dependent leukotriene export from mastocytoma cells

1991 • 64 citations

Analysis of MRP gene expression and function in HL60 cells isolated for resistance to adriamycin.

1994 • 60 citations

ATP stimulates the uptake of S‐dinitrophenylglutathione by rat liver plasma membrane vesicles

1988 • 57 citations

Expression of the multidrug resistance-associated protein (MRP) gene in human lung tumours and normal tissue as determined by in situ hybridisation

1994 • 54 citations

Noninvasive assessment of hepatobiliary and renal elimination of cysteinyl leukotrienes by positron emission tomography

1995 • 37 citations

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