Genistein modulates the decreased drug accumulation in non-P-glycoprotein mediated multidrug resistant tumour cells

Genistein, a specific inhibitor of tyrosine-specific protein kinases.

1987 • 3,773 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Quantitative analysis of MDR1 (multidrug resistance) gene expression in human tumors by polymerase chain reaction.

1990 • 736 citations

Inhibitory effects of the tyrosine kinase inhibitor genistein on mammalian DNA topoisomerase II.

1989 • 559 citations

Overexpression of a M(r) 110,000 vesicular protein in non-P-glycoprotein-mediated multidrug resistance.

1993 • 508 citations

Immunohistochemical detection of P-glycoprotein: prognostic correlation in soft tissue sarcoma of childhood.

1990 • 462 citations

Reversal mechanism of multidrug resistance by verapamil: direct binding of verapamil to P-glycoprotein on specific sites and transport of verapamil outward across the plasma membrane of K562/ADM cells.

1989 • 367 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

Multifactorial drug resistance in an adriamycin-resistant human small cell lung carcinoma cell line.

1987 • 266 citations

Phorbol esters induce multidrug resistance in human breast cancer cells.

1988 • 241 citations

MDR1 Gene Expression in Lung Cancer

1989 • 182 citations

Different mechanisms of decreased drug accumulation in doxorubicin and mitoxantrone resistant variants of the MCF7 human breast cancer cell line

1991 • 165 citations

Subcellular distribution of daunorubicin in P-glycoprotein-positive and -negative drug-resistant cell lines using laser-assisted confocal microscopy.

1991 • 160 citations

Reduced DNA topoisomerase II activity and drug-induced DNA cleavage activity in an adriamycin-resistant human small cell lung carcinoma cell line.

1990 • 157 citations

Non-P-glycoprotein mediated mechanism for multidrug resistance precedes P-glycoprotein expression during in vitro selection for doxorubicin resistance in a human lung cancer cell line

1991 • 156 citations

Pharmacological and biological evidence for differing mechanisms of doxorubicin resistance in two human tumor cell lines.

1988 • 154 citations

Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein

1993 • 147 citations

Transfection with Protein Kinase Cα Confers Increased Multidrug Resistance to MCF-7 Cells Expressing P-Glycoprotein

1991 • 146 citations

Mechanisms of multidrug resistance in HL60 cells

1989 • 140 citations

Overexpression of the MDRL gene in blast cells from patients with acute myelocytic leukemia is associated with decreased anthracycline accumulation that can be restored by cyclosporin‐A

1990 • 136 citations

The Biochemistry Of P-Glycoprotein-Mediated Multidrug Resistance

1989 • 132 citations

Membrane transport of anthracyclines

1982 • 121 citations

Mechanisms of multidrug resistance in HL60 cells: detection of resistance-associated proteins with antibodies against synthetic peptides that correspond to the deduced sequence of P-glycoprotein.

1990 • 116 citations

Correlation of MDR1 Gene Expression With Chemotherapy in Neuroblastoma

1989 • 112 citations

Regulation by phorbol ester and protein kinase C inhibitors, and by a protein phosphatase inhibitor (okadaic acid), of P-glycoprotein phosphorylation and relationship to drug accumulation in multidrug-resistant human KB cells.

1992 • 111 citations

The antiproliferative effects of tyrosine kinase inhibitors tyrphostins on a human squamous cell carcinoma in vitro and in nude mice.

1991 • 111 citations

Analysis of P-glycoprotein phosphorylation in HL60 cells isolated for resistance to vincristine.

1991 • 109 citations

Effect of calcium antagonists on the chemosensitivity of two multidrug-resistant human tumour cell lines which do not overexpress P-glycoprotein

1989 • 107 citations

Early multidrug resistance, defined by changes in intracellular doxorubicin distribution, independent of P-glycoprotein

1991 • 106 citations

Quantitative Determination of Factors Contributing to Doxorubicin Resistance in Multidrug-Resistant Cells

1989 • 102 citations

Energy-dependent processes involved in reduced drug accumulation in multidrug-resistant human lung cancer cell lines without P-glycoprotein expression

1992 • 100 citations

Effects of the tyrosine-kinase inhibitor genistein on DNA synthesis and phospholipid-derived second messenger generation in mouse 10T1/2 fibroblasts and rat liver T51B cells

1989 • 89 citations

Modulation of P-glycoprotein phosphorylation and drug transport by sodium butyrate

1992 • 85 citations

Retention of activity by selected anthracyclines in a multidrug resistant human large cell lung carcinoma line without P-glycoprotein hyperexpression

1991 • 66 citations

Binding of an optically pure photoaffinity analogue of verapamil, LU-49888, to P-glycoprotein from multidrug-resistant human leukemic cell lines.

1990 • 63 citations

Increase of daunorubicin and vincristine accumulation in multidrug resistant human ovarian carcinoma cells by a monoclonal antibody reacting with P-glycoprotein

1988 • 58 citations

Quantification by laser scan microscopy of intracellular doxorubicin distribution

1992 • 52 citations

Probing daunorubicin accumulation defects in non‐P‐glycoprotein expressing multidrug‐resistant cell lines using digitonin

1992 • 30 citations

Herbimycin A, an inhibitor of tyrosine kinase, prolongs survival of mice inoculated with myeloid leukemia C1 cells with high expression of v-abl tyrosine kinase.

1992 • 25 citations

Differential sensitivity of multi‐drug‐resistant and ‐sensitive cells to resistance‐modifying agents and the relation with reversal of anthracycline resistance

1990 • 18 citations

Establishment of a human leukemia subline resistant to the growth‐inhibitory effect of 12‐o‐tetradecanoylphorbol 13‐acetate (TPA) and showing non‐P‐glycoprotein‐mediated multi‐drug resistance

1991 • 15 citations

Herbimycin A, an inhibitor of tyrosine kinase, prolongs survival of mice inoculated with myeloid leukemia C1 cells with high expression of v-abl tyrosine kinase.

1992 • 4 citations