FROM VACUOLAR GS-X PUMPS TO MULTISPECIFIC ABC TRANSPORTERS

Identification of the Cystic Fibrosis Gene: Cloning and Characterization of Complementary DNA

1989 • 7,327 citations

Distantly related sequences in the alpha- and beta-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold.

1982 • 5,284 citations

Exploring the Metabolic and Genetic Control of Gene Expression on a Genomic Scale

1997 • 4,531 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

Stress-Induced Phenylpropanoid Metabolism.

1995 • 3,751 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

The Glut athione S-Transferase Supergene Family: Regulation of GST and the Contribution of the lsoenzymes to Cancer Chemoprotection and Drug Resistance Part I

1995 • 3,492 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

H2O2 from the oxidative burst orchestrates the plant hypersensitive disease resistance response

1994 • 2,757 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Glutathione Transferases—Structure and Catalytic Activit

1988 • 1,751 citations

THE FUNCTIONS AND REGULATION OF GLUTATHIONE S-TRANSFERASES IN PLANTS

1996 • 1,349 citations

Structural model of ATP-binding proteing associated with cystic fibrosis, multidrug resistance and bacterial transport

1990 • 1,149 citations

Prosite: a dictionary of sites and patterns in proteins

1992 • 952 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

A glutathione S-transferase involved in vacuolar transfer encoded by the maize gene Bronze-2

1995 • 660 citations

The ATP-dependent glutathione S-conjugate export pump

1992 • 656 citations

cDNA Cloning of the Hepatocyte Canalicular Isoform of the Multidrug Resistance Protein, cMrp, Reveals a Novel Conjugate Export Pump Deficient in Hyperbilirubinemic Mutant Rats

1996 • 641 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

The yeast STE6 gene encodes a homologue of the mammalian multidrug resistance P-glycoprotein

1989 • 604 citations

Phosphatidylcholine translocase: A physiological role for the mdr2 gene

1994 • 600 citations

Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis.

1988 • 589 citations

A new pathway for vacuolar cadmium sequestration in Saccharomyces cerevisiae : YCF1-catalyzed transport of bis(glutathionato)cadmium

1997 • 580 citations

Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.

1996 • 569 citations

Generation of cAMP-Activated Chloride Currents by Expression of CFTR

1991 • 550 citations

The Heavy Metal-Binding Peptides of Plants

1990 • 534 citations

Oxidative Stress in Plants

2020 • 528 citations

Lipid Peroxidation: Mechanisms, Analysis, Enzymology and Biological Relevance

1985 • 520 citations

Higher plant metabolism of xenobiotics: the ???green liver??? concept

1994 • 504 citations

Plant metabolism of xenobiotics

1992 • 490 citations

Subcellular Localization of Cadmium and Cadmium-Binding Peptides in Tobacco Leaves

1990 • 472 citations

Transport of Metal-binding Peptides by HMT1, A Fission Yeast ABC-type Vacuolar Membrane Protein

1995 • 468 citations

MgATP-Dependent Transport of Phytochelatins Across the Tonoplast of Oat Roots

1995 • 460 citations

Complete inventory of the yeast ABC proteins

1997 • 455 citations

Saccharomyces cerevisiae STE6 gene product: a novel pathway for protein export in eukaryotic cells.

1989 • 443 citations

The Yeast Cadmium Factor Protein (YCF1) Is a Vacuolar Glutathione S-Conjugate Pump

1996 • 442 citations

PDR5, a novel yeast multidrug resistance conferring transporter controlled by the transcription regulator PDR1.

1994 • 439 citations

Amplification of a Gene Related to Mammalian mdr Genes in Drug-Resistant Plasmodium falciparum

1989 • 439 citations

PHYTOCHELATINS

1990 • 437 citations

Detoxication of base propenals and other alpha,beta-unsaturated aldehyde products of radical reactions and lipid peroxidationby human glutathione transferases.

1994 • 412 citations

Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter.

1992 • 410 citations

Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex

1992 • 407 citations

Electrogenic Ion Pumps

1981 • 403 citations

Glutathione metabolism and possible biological roles in higher plants

1980 • 395 citations

Virus proteins that counteract host immune defenses

1992 • 392 citations

Gene Families: The Taxonomy of Protein Paralogs and Chimeras

1997 • 387 citations

ATP-dependent glutathione S-conjugate 'export' pump in the vacuolar membrane of plants

1993 • 379 citations

The ABC of channel regulation

1995 • 375 citations

A yeast metal resistance protein similar to human cystic fibrosis transmembrane conductance regulator (CFTR) and multidrug resistance-associated protein.

1994 • 364 citations

Proton-Coupled Sugar and Amino Acid Transporters in Plants

1993 • 359 citations

Oxidative stress in plants

1995 • 351 citations

Synthesis of Phytoalexins in Sorghum as a Site-Specific Response to Fungal Ingress

1990 • 339 citations

Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein

1992 • 328 citations

Tonoplast energization: Two H⁺ pumps, one membrane

1987 • 317 citations

Old Enzymes for a New Job (Herbicide Detoxification in Plants)

1996 • 301 citations

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

1990 • 299 citations

Immunochemical detection of the multidrug resistance-associated protein MRP in human multidrug-resistant tumor cells by monoclonal antibodies.

1994 • 284 citations

Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics.

1995 • 283 citations

AtMRP1 gene of Arabidopsis encodes a glutathione S -conjugate pump: Isolation and functional definition of a plant ATP-binding cassette transporter gene

1997 • 276 citations

An ABC‐transporter of Arabidopsis thaliana has both glutathione‐conjugate and chlorophyll catabolite transport activity

1998 • 273 citations

AtMRP2, an Arabidopsis ATP Binding Cassette Transporter Able to Transport Glutathione S-Conjugates and Chlorophyll Catabolites: Functional Comparisons with AtMRP1

1998 • 269 citations

Plant cytochrome p450

1994 • 254 citations

Vacuolar H+-Translocating Pyrophosphatase

1993 • 238 citations

Membrane topology distinguishes a subfamily of the ATP‐binding cassette (ABC) transporters

1997 • 237 citations

Multidrug resistance mediated by the multidrug resistance protein (MRP) gene

1996 • 235 citations

Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia.

1990 • 229 citations

Membrane Topology of the Multidrug Resistance Protein (MRP)

1997 • 215 citations

Cadmium tolerance mediated by the yeast AP-1 protein requires the presence of an ATP-binding cassette transporter-encoding gene, YCF1.

1994 • 214 citations

Membrane Topology and Glycosylation of the Human Multidrug Resistance-associated Protein

1996 • 209 citations

Crop Photosynthesis: Spatial and Temporal Determinants

1993 • 194 citations

Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels.

1995 • 191 citations

Evolution of Glutathione Metabolism

1991 • 182 citations

Expression and RNA Splicing of the Maize Glutathione S-Transferase Bronze2 Gene Is Regulated by Cadmium and Other Stresses

1997 • 176 citations

The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1.

1996 • 170 citations

Structure-activity relationships of 4-hydroxyalkenals in the conjugation catalysed by mammalian glutathione transferases

1987 • 163 citations

Genetics and biochemistry of yeast multidrug resistance

1994 • 157 citations

Altered Drug-stimulated ATPase Activity in Mutants of the Human Multidrug Resistance Protein

1996 • 154 citations

Degradation of glutathione S‐conjugates by a carboxypeptidase in the plant vacuole

1996 • 147 citations

The GS-X Pump in Plant, Yeast, and Animal Cells: Structure, Function, and Gene Expression

1997 • 144 citations

Structure of an mdr-like gene from Arabidopsis thaliana. Evolutionary implications.

1992 • 142 citations

Evidence for an alternate model of human P-glycoprotein structure and biogenesis.

1993 • 138 citations

ATP/Mg2+-dependent Cardiac Transport System for Glutathione S-Conjugates

1989 • 137 citations

Interactions oftrans-cinnamic acid, its related phenolic allelochemicals, and abscisic acid in seedling growth and seed germination of lettuce

1993 • 135 citations

ATP-dependent S-(2,4-dinitrophenyl)glutathione transport in canalicular plasma membrane vesicles from rat liver

1991 • 132 citations

Study of membrane orientation and glycosylated extracellular loops of mouse P-glycoprotein by in vitro translation.

1991 • 132 citations

Different Energization Mechanisms Drive the Vacuolar Uptake of a Flavonoid Glucoside and a Herbicide Glucoside

1996 • 127 citations

Structure and expression of the messenger RNA encoding the murine multidrug resistance protein, an ATP-binding cassette transporter.

1996 • 108 citations

Location of a protease-hypersensitive region in the multidrug resistance protein (MRP) by mapping of the epitope of MRP-specific monoclonal antibody QCRL-1.

1996 • 106 citations

How Plants Dispose of Chlorophyll Catabolites

1996 • 101 citations

Catabolites of chlorophyll in senescing barley leaves are localized in the vacuoles of mesophyll cells

1988 • 100 citations

MEMBRANE TRANSPORT CARRIERS

1996 • 98 citations

ACTIVATION OF PROMUTAGENS BY GREEN PLANTS

1993 • 97 citations

apd1 +, a Gene Required for Red Pigment Formation in ade6 Mutants of Schizosaccharomyces pombe, Encodes an Enzyme Required for Glutathione Biosynthesis: A Role for Glutathione and a Glutathione-Conjugate Pump

1997 • 94 citations

Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats.

1993 • 93 citations

Detoxification of xenobiotics in plant cells by glutathione conjugation and vacuolar compartmentalization: a fluorescent assay using monochlorobimane

1997 • 92 citations

A herbicide antidote (safener) induces the activity of both the herbicide detoxifying enzyme and of a vacuolar transporter for the detoxified herbicide

1994 • 92 citations

Magnesium Adenosine 5[prime]-Triphosphate-Energized Transport of Glutathione-S-Conjugates by Plant Vacuolar Membrane Vesicles

1995 • 89 citations

Vacuolar uptake of the phytoalexin medicarpin by the glutathione conjugate pump

1997 • 85 citations

Chloroplast senescence

1992 • 82 citations

Accumulation of Coumarylglucosides in Vacuoles of Barley Mesophyll Protoplasts

1985 • 78 citations

Tridiphane [2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane] an atrazine synergist: Enzymatic conversion to a potent glutathione S-transferase inhibitor

1986 • 77 citations

Molecular cloning and expression of a cyclic AMP-activated chloride conductance regulator: a novel ATP-binding cassette transporter.

1996 • 70 citations

Multiple transport systems for organic anions across the bile canalicular membrane.

1994 • 68 citations

1-Chloro-2,4-Dinitrobenzene-Elicited Increase in Vacuolar Glutathione-S-Conjugate Transport Activity

1995 • 62 citations

Differential expression of genes coding for ABC transporters after treatment of Arabidopsis thaliana with xenobiotics

1997 • 60 citations

ATP stimulates the uptake of S‐dinitrophenylglutathione by rat liver plasma membrane vesicles

1988 • 57 citations

Transport of Oxidized Glutathione into Barley Vacuoles: Evidence for the Involvement of the Glutathione-S-Conjugate ATPase

1993 • 51 citations

Mutational analysis of the Saccharomyces cerevisiae ATP‐binding cassette transporter protein Ycf1p

1997 • 51 citations

Glutathione S-cinnamoyl transferases in plants

1991 • 47 citations

GLUTATHIONE AND GLUCOSIDE CONJUGATION IN HERBICIDE SELECTIVITY

1991 • 47 citations

A potato cDNA encoding a homologue of mammalian multidrug resistant P-glycoprotein

1996 • 45 citations

Rapid metabolism of isoflavonoids in elicitor-treated cell suspension cultures of Pueraria lobata

1995 • 45 citations

Direct energization of bile acid transport into plant vacuoles.

1993 • 44 citations

Directly Energized Uptake of β-Estradiol 17-(β-d-Glucuronide) in Plant Vacuoles Is Strongly Stimulated by Glutathione Conjugates

1998 • 43 citations

Cloning and expression analyses of AtMRP4, a novel MRP-like gene from Arabidopsis thaliana

1998 • 43 citations

Evidence for different transport systems for oxidized glutathione and S-dinitrophenyl glutathione in human erythrocytes

1986 • 37 citations

Cloning and characterisation of a novel P-glycoprotein homologue from barley

1997 • 31 citations

Effect of N,N-diallyl-2,2-dichloroacetamide (R-25788) on efflux and synthesis of glutathione in tobacco suspension cultures

1982 • 31 citations

ATP-dependent transport of organic anions in secretory vesicles of Saccharomyces cerevisiae.

1994 • 30 citations

Accumulation and metabolism of medicarpin and maackiain malonylglucosides in elicited chickpea (Cicer arietinum L.) cell suspension cultures

1993 • 29 citations

Tonoplast Adenosine Triphosphatase and Inorganic Pyrophosphatase

1990 • 24 citations

Genomic and cDNA Sequence Tags of the Hyperthermophilic Archaeon Pyrobaculum Aerophilum

1996 • 16 citations

Doxorubicin selection for MDR1/P-glycoprotein reduces swelling-activated K+ and Cl- currents in MES-SA cells

1996 • 15 citations

Detoxification of xenobiotics by plant cells: characterisation of vacuolar amphiphilic organic anion transporters

1996 • 12 citations

Regulation of canalicular transport activities.

1996 • 8 citations

Activation of corn glutathione S-transferase enzymes B coumaric acid and 7-hydroxycoumarin

1993 • 8 citations