Multidrug Resistance Protein (MRP)-mediated Transport of Leukotriene C4 and Chemotherapeutic Agents in Membrane Vesicles

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

1994 • 850 citations

Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells.

1994 • 777 citations

The human multidrug resistance-associated protein MRP is a plasma membrane drug-efflux pump.

1994 • 685 citations

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

1994 • 635 citations

Overexpression of the gene encoding the multidrug resistance-associated protein results in increased ATP-dependent glutathione S-conjugate transport.

1994 • 621 citations

Role of glutathione in the export of compounds from cells by the multidrug-resistance-associated protein.

1995 • 501 citations

ATP-dependent transport of glutathione S-conjugates by the multidrug resistance-associated protein.

1994 • 435 citations

Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.

1987 • 343 citations

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

1990 • 299 citations

ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump

1996 • 290 citations

Characterization of a new drug-resistant human myeloma cell line that expresses P-glycoprotein.

1986 • 275 citations

ATP-dependent 17β-Estradiol 17-(β-D-Glucuronide) Transport by Multidrug Resistance Protein (MRP)

1996 • 265 citations

Increased vinblastine binding to membrane vesicles from multidrug-resistant KB cells.

1986 • 255 citations

Regulation by glutathione of drug transport in multidrug-resistant human lung tumour cell lines overexpressing multidrug resistance-associated protein

1995 • 206 citations

GS-X pump is functionally overexpressed in cis-diamminedichloroplatinum (II)-resistant human leukemia HL-60 cells and down-regulated by cell differentiation.

1994 • 204 citations

Detection of the M(r) 190,000 multidrug resistance protein, MRP, with monoclonal antibodies.

1994 • 196 citations

Characterization of the ATP‐dependent leukotriene C₄ export carrier in mastocytoma cells

1994 • 157 citations

Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein

1993 • 147 citations

Characterization of the M(r) 190,000 multidrug resistance protein (MRP) in drug-selected and transfected human tumor cell.

1995 • 145 citations

Mechanisms of multidrug resistance in HL60 cells

1989 • 140 citations

ATP/Mg2+-dependent Cardiac Transport System for Glutathione S-Conjugates

1989 • 137 citations

Purification to homogeneity and the N-terminal sequence of human leukotriene C4 synthase: a homodimeric glutathione S-transferase composed of 18-kDa subunits.

1993 • 128 citations

Derivation and preliminary characterisation of adriamycin resistant lines of human lung cancer cells

1986 • 123 citations

Multidrug Resistance and Chemosensitization: Therapeutic Implications for Cancer Chemotherapy

1990 • 116 citations

Transport properties of P-glycoprotein in plasma membrane vesicles from multidrug-resistant Chinese hamster ovary cells

1992 • 114 citations

Leukotrienes: Biosynthesis, transport, inactivation, and analysis

1992 • 90 citations

A Possible Role of Glutathione as an Endogenous Agonist at the N‐Methyl‐<scp>d</scp>‐Aspartate Recognition Domain in Rat Brain

1995 • 67 citations

ATP‐dependent leukotriene export from mastocytoma cells

1991 • 64 citations

Multiple Canalicular Transport Mechanisms for Glutathione S-Conjugates

1995 • 63 citations

Leukotriene C4 uses a probenecid-sensitive export carrier that does not recognize leukotriene B4.

1992 • 57 citations

Functional expression of P-glycoprotein encoded by the mouse mdr3 gene in yeast cells.

1993 • 56 citations

The 1991 Merck Frosst Award. Multidrug resistance in small cell lung cancer

1992 • 55 citations

Characterization and functional reconstitution of the multidrug transporter

1995 • 49 citations

Functional studies of P-glycoprotein in inside-out plasma membrane vesicles derived from murine erythroleukemia cells overexpressing MDR 3. Properties and kinetics of the interaction of vinblastine with P-glycoprotein and evidence for its active mediated transport.

1994 • 49 citations

Evidence for leukotriene C₄ transport mediated by an ATP‐dependent glutathione S‐conjugate carrier in rat heart and liver plasma membranes

1989 • 48 citations

Photoaffinity Labeling of P-Glycoprotein in Multidrug-Resistant Cells

1992 • 39 citations

Membrane transport of conjugated and unconjugated bile acids into hepatocytes is susceptible to SH-blocking reagents

1990 • 26 citations

Facile Preparation of Inside-Out Plasma Membrane Vesicles from Tumor Cells for Functional Studies of Pharmacologically Relevant Translocating ATPases

1995 • 7 citations