An improved polarized rat hepatoma hybrid cell line: generation and comparison with its hepatoma relatives and hepatocytes in vivo

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

Quantitative estimation of proteins by electrophoresis in agarose gel containing antibodies

1966 • 4,504 citations

Polyacrylamide Gel Electrophoresis of Viral Proteins

1971 • 1,477 citations

Apoptosis: Mechanisms and Roles in Pathology

1991 • 1,368 citations

The Biochemistry of Glycoproteins and Proteoglycans

1980 • 1,231 citations

Membrane properties of living mammalian cells as studied by enzymatic hydrolysis of fluorogenic esters.

1966 • 1,150 citations

Cell-cell and cell-matrix interactions differentially regulate the expression of hepatic and cytoskeletal genes in primary cultures of rat hepatocytes.

1988 • 534 citations

Spheroidal aggregate culture of rat liver cells: histotypic reorganization, biomatrix deposition, and maintenance of functional activities.

1985 • 508 citations

The galactose-specific recognition system of mammalian liver: The route of ligand internalization in rat hepatocytes

1980 • 484 citations

Biogenesis of the rat hepatocyte plasma membrane in vivo: comparison of the pathways taken by apical and basolateral proteins using subcellular fractionation.

1987 • 383 citations

Characterization of differentiated and dedifferentiated clones from a rat hepatoma

1975 • 381 citations

Regulation of Hepatic Metabolism

1976 • 314 citations

An electron microscope autoradiographic study of the carbohydrate recognition systems in rat liver. I. Distribution of 125I-ligands among the liver cell types.

1979 • 310 citations

Isolation of rat hepatocyte plasma membranes. I. Presence of the three major domains.

1983 • 306 citations

Studies on a mammalian hepatic binding protein specific for asialoglycoproteins. Evidence for receptor recycling in isolated rat hepatocytes.

1980 • 270 citations

Receptor-mediated endocytosis of epidermal growth factor by hepatocytes in the perfused rat liver: ligand and receptor dynamics.

1984 • 265 citations

Apoptotic hepatocytes become insoluble in detergents and chaotropic agents as a result of transglutaminase action

1989 • 254 citations

Complete amino acid sequence of human intestinal aminopeptidase N as deduced from cloned cDNA

1988 • 241 citations

Transport models for secretory IgA and secretory IgM.

1981 • 240 citations

Cloning and Expression of a cDNA Coding for a Rat Liver Plasma Membrane Ecto-ATPase

1989 • 240 citations

A QUANTITATIVE COMPARISON OF FORMATION OF SPONTANEOUS AND VIRUS-PRODUCED VIABLE HYBRIDS

1969 • 230 citations

WIF-B cells: an in vitro model for studies of hepatocyte polarity.

1993 • 209 citations

Endocytosis and signals for internalization

1991 • 209 citations

Long-term culture of adult rat hepatocyte spheroids

1992 • 201 citations

Antibody-induced linkages of plasma membrane proteins to intracellular actomyosin-containing filaments in cultured fibroblasts.

1977 • 193 citations

Primary Structure of Rat Liver Dipeptidyl Peptidase IV Deduced from Its cDNA and Identification of the NH2-Terminal Signal Sequence as the Membrane-anchoring Domain

1989 • 180 citations

The liver and IgA: Immunological, cell biological and clinical implications

1989 • 177 citations

Isolated rat hepatocyte couplets: a primary secretory unit for electrophysiologic studies of bile secretory function.

1984 • 150 citations

Evidence for a continual exchange of 5′-nucleotidase between the cell surface and cytoplasmic membranes in cultured rat fibroblasts

1982 • 147 citations

Identification of rat hepatocyte plasma membrane proteins using monoclonal antibodies.

1985 • 140 citations

Biochemical characterization of domain-specific glycoproteins of the rat hepatocyte plasma membrane.

1985 • 134 citations

Transcellular transport of polymeric IgA in the rat hepatocyte: biochemical and morphological characterization of the transport pathway.

1985 • 134 citations

5'nucleotidase is sorted to the apical domain of hepatocytes via an indirect route [published erratum appears in J Cell Biol 1993 Nov;123(3):following 767]

1992 • 121 citations

Immunofluorescence analysis of the time-course of extinction, reexpression, and activation of albumin production in rat hepatoma-mouse fibroblast heterokaryons and hybrids.

1981 • 114 citations

A domain-specific marker for the hepatocyte plasma membrane: localization of leucine aminopeptidase to the bile canalicular domain.

1983 • 111 citations

Receptor-mediated endocytosis of asialoglycoproteins by rat liver hepatocytes: biochemical characterization of the endosomal compartments.

1985 • 109 citations

Intracellular and transcellular transport of secretory component and albumin in rat hepatocytes.

1983 • 100 citations

Reestablishment of cell polarity of rat hepatocytes in primary culture

1993 • 93 citations

Endogenous and exogenous domain markers of the rat hepatocyte plasma membrane.

1985 • 92 citations

[27] Karyotyping

1979 • 86 citations

Formation of plasma membrane domains in rat hepatocytes and hepatoma cell lines in culture

1988 • 84 citations

HNF4 and HNF1 as well as a panel of hepatic functions are extinguished and reexpressed in parallel in chromosomally reduced rat hepatoma-human fibroblast hybrids.

1993 • 73 citations

Solubilization and purification of rat liver 5′-nucleotidase by use of a zwitterionic detergent and a monoclonal-antibody immunoadsorbent

1982 • 72 citations

The establishment of hepatocyte cell surface polarity during fetal liver development

1987 • 72 citations

Hybrid cell lines constitute a potential reservoir of polarized cells: isolation and study of highly differentiated hepatoma-derived hybrid cells able to form functional bile canaliculi in vitro.

1991 • 67 citations

cDNA cloning for a bile canaliculus domain-specific membrane glycoprotein of rat hepatocytes.

1987 • 66 citations

Expression of the rat CD26 Antigen (dipeptidyl peptidase IV) on subpopulations of rat lymphocytes

1991 • 65 citations

The Effect of Cholinergic Substances on the Discharges from Thermal Receptors.

1953 • 64 citations

The Formation of Bile Canaliculi in Human Hepatoma Cell Lines

1990 • 63 citations

Secretory component: The polymeric immunoglobulin receptor

1985 • 63 citations

Transcellular transport of fluorescein in hepatocyte monolayers: evidence for functional polarity of cells in culture.

1982 • 56 citations

Transepithelial transport and mucosal defence II: secretion of IgA

1992 • 54 citations

Ligand- and weak base-induced redistribution of asialoglycoprotein receptors in hepatoma cells.

1987 • 51 citations

Dynamics of four rat liver plasma membrane proteins and polymeric IgA receptor. Rates of synthesis and selective loss into the bile.

1992 • 45 citations

Immunoperoxidase localization of albumin and fibrinogen in rat liver fixed by perfusion or immersion: effect of saponin on the intracellular penetration of labeled antibodies.

1982 • 41 citations

Preservation of hepatocyte plasma membrane domains during cell division in situ in regenerating rat liver

1986 • 40 citations

External and Internal Signals for Epithelial Cell Surface Polarization

1989 • 40 citations

Mechanisms of Bile Secretion: lnsights from the Isolated Rat Hepatocyte Couplet

1988 • 37 citations

A domain-specific marker for the hepatocyte plasma membrane. III. Isolation of bile canalicular membrane by immunoadsorption.

1984 • 30 citations

Identification of cell surface dipeptidylpeptidase IV in human fibroblasts

1983 • 28 citations

Dedifferentiated variants of a rat hepatoma: Partial reversion induced by cell aggregation

1980 • 28 citations

Localisation of 5′-nucleotidase in a rat liver cell line using a monoclonal antibody and indirect immunofluorescent labelling

1983 • 23 citations

Coordinate secretion of mouse alphafetoprotein, mouse albumin and rat albumin by mouse hepatoma‐rat hepatoma hybrid cells

1980 • 22 citations

MONOCLONAL ANTIBODIES RECOGNIZING THE SECRETED AND MEMBRANE DOMAINS OF THE IgA DIMER RECEPTOR*

1983 • 22 citations

Ligand-induced modulation of the hepatic receptor for asialoglycoproteins in the human hepatoblastoma cell line, Hep G2.

1987 • 22 citations

Cytochemical reactivity of T? lymphocytes in human lymphatic tissue for dipeptidylaminopeptidase IV

1982 • 21 citations

An ultrastructural study of rat hepatoma cells in culture, their variants and revertants

1986 • 11 citations

Aminopeptidases and Proteolipids of Intestinal Brush Border

1983 • 10 citations

The Giemsa-11 technique for species-specific chromosome differentiation

1984 • 9 citations