Multispecific organic anion transporter is responsible for the biliary excretion of the camptothecin derivative irinotecan and its metabolites in rats.

Intracellular roles of SN-38, a metabolite of the camptothecin derivative CPT-11, in the antitumor effect of CPT-11.

1991 • 855 citations

The Current Status of Camptothecin Analogues as Antitumor Agents

1993 • 614 citations

Metabolic fate of irinotecan in humans: correlation of glucuronidation with diarrhea.

1994 • 503 citations

A kinetic and Mechanistic Study of the Hydrolysis of Camptothecin and Some Analogues

1992 • 456 citations

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

1989 • 406 citations

Validation of a recording spectrophotometric method for measurement of membrane-associated Mg- and NaK-ATPase activity.

1979 • 341 citations

The structural basis of camptothecin interactions with human serum albumin: impact on drug stability

1994 • 316 citations

Phase I and pharmacokinetic trial of weekly CPT-11.

1993 • 300 citations

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

1990 • 299 citations

Metabolism and pharmacokinetics of the camptothecin analogue CPT-11 in the mouse.

1990 • 292 citations

Comparison of Topoisomerase I Inhibition, DNA Damage, and Cytotoxicity of Camptothecin Derivatives Presently in Clinical Trials

1994 • 291 citations

Phase I Study of Weekly Intravenous Infusions of CPT-11, a New Derivative of Camptothecin, in the Treatment of Advanced Non-Small-Cell Lung Cancer

1991 • 275 citations

An early phase II study of CPT-11: a new derivative of camptothecin, for the treatment of leukemia and lymphoma.

1990 • 234 citations

Recent advances in carrier-mediated hepatic uptake and biliary excretion of xenobiotics.

1996 • 218 citations

Phase I and pharmacological study of the novel topoisomerase I inhibitor 7-ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin (CPT-11) administered as a ninety-minute infusion every 3 weeks.

1994 • 195 citations

Mechanism of glutathione S-conjugate transport in canalicular and basolateral rat liver plasma membranes.

1990 • 164 citations

Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats.

1992 • 162 citations

Relationship between Development of Diarrhea and the Concentration of SN‐38, an Active Metabolite of CPT‐11, in the Intestine and the Blood Plasma of Athymic Mice Following Intraperitoneal Administration of CPT‐11

1993 • 142 citations

ATP-dependent S-(2,4-dinitrophenyl)glutathione transport in canalicular plasma membrane vesicles from rat liver

1991 • 132 citations

Identification and kinetics of a ?-glucuronide metabolite of SN-38 in human plasma after administration of the camptothecin derivative irinotecan

1995 • 128 citations

Phase I Study and Pharmacokinetics of CPT-11 With 5-Day Continuous Infusion

1992 • 122 citations

Experimental studies on biochemical modulation targeting topoisomerase I and II in human tumor xenografts in nude mice

1992 • 112 citations

Reversed-phase high-performance liquid chromatographic method for the simultaneous quantitation of the carboxylate and lactone forms of the camptothecin derivative irinotecan, CPT-11, and its metabolite SN-38 in plasma

1994 • 110 citations

Nonlinear pharmacokinetics of CPT-11 in rats.

1990 • 109 citations

Identification of the metabolites of irinotecan, a new derivative of camptothecin, in rat bile and its biliary excretion

1991 • 101 citations

Protective Effects of Kampo Medicines and Baicalin against Intestinal Toxicity of a New Anticancer Camptothecin Derivative, Irinotecan Hydrochloride (CPT‐11), in Rats

1995 • 97 citations

Kinetic analysis of hepatobiliary transport of organic anions in Eisai hyperbilirubinemic mutant rats.

1993 • 93 citations

Kinetic analysis of hepatobiliary transport for conjugated metabolites in the perfused liver of mutant rats (EHBR) with hereditary conjugated hyperbilirubinemia.

1995 • 75 citations

Pharmacokinetics of irinotecan and its metabolites in human blood, bile, and urine

1995 • 74 citations

A Pharmacokinetic and Pharmacodynamic Analysis of CPT‐11 and Its Active Metabolite SN‐38

1995 • 70 citations

Multiple transport systems for organic anions across the bile canalicular membrane.

1994 • 68 citations

ATP-dependent organic anion transport system in normal and TR- rat liver canalicular membranes

1992 • 65 citations

Multiple Canalicular Transport Mechanisms for Glutathione S-Conjugates

1995 • 63 citations

Different biliary excretion systems for glucuronide and sulfate of a model compound; study using Eisai hyperbilirubinemic rats.

1995 • 60 citations

Pharmacological Correlation between Total Drug Concentration and Lactones of CPT‐11 and SN‐38 in Patients Treated with CPT‐11

1995 • 54 citations

Multiple systems for the biliary excretion of organic anions in rats: liquiritigenin conjugates as model compounds.

1994 • 51 citations

Organic anion-transporting ATPase of rat liver. I. Purification, photoaffinity labeling, and regulation by phosphorylation.

1994 • 37 citations

Study on the mechanisms of diarrhea induced by a new anticancer camptothecin derivative, irinotecan hydrochloride (CPT-11), in rats.

1995 • 33 citations

Characterization of Rose Bengal binding to sinusoidal and bile canalicular plasma membrane from rat liver

1989 • 28 citations

Cytogenetic Effects of CPT-11 and Its Active Metabolite, SN-38 on Human Lymphocytes

1993 • 27 citations

Action of 7-ethylcamptothecin on tumor cells and its disposition in mice.

1987 • 18 citations