The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

ABC Transporters: From Microorganisms to Man

1992 • 3,956 citations

BIOCHEMISTRY OF MULTIDRUG RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER

1993 • 3,515 citations

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Leukotrienes and Lipoxins: Structures, Biosynthesis, and Biological Effects

1987 • 2,237 citations

THE BIOCHEMISTRY OF P-GLYCOPROTEIN-MEDIATED MULTIDRUG RESISTANCE

1989 • 2,060 citations

Leukotriene C: a slow-reacting substance from murine mastocytoma cells.

1979 • 992 citations

Overexpression of multidrug resistance-associated protein (MRP) increases resistance to natural product drugs.

1994 • 635 citations

In vivo circumvention of P-glycoprotein-mediated multidrug resistance of tumor cells with SDZ PSC 833.

1991 • 364 citations

Multidrug resistance in a human small cell lung cancer cell line selected in adriamycin.

1987 • 343 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

ATP-dependent primary active transport of cysteinyl leukotrienes across liver canalicular membrane. Role of the ATP-dependent transport system for glutathione S-conjugates.

1990 • 299 citations

The MRP gene associated with a non-P-glycoprotein multidrug resistance encodes a 190-kDa membrane bound glycoprotein.

1993 • 297 citations

Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D₄ receptor antagonist

1989 • 266 citations

Defective ATP-dependent bile canalicular transport of organic anions in mutant (TR-) rats with conjugated hyperbilirubinemia.

1990 • 229 citations

Cyclosporins as drug resistance modifiers

1992 • 205 citations

Multidrug Resistance

1989 • 166 citations

Canalicular transport of reduced glutathione in normal and mutant Eisai hyperbilirubinemic rats.

1992 • 162 citations

Characterization of the ATP‐dependent leukotriene C₄ export carrier in mastocytoma cells

1994 • 157 citations

Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein

1993 • 147 citations

Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion

1987 • 143 citations

ATP-dependent S-(2,4-dinitrophenyl)glutathione transport in canalicular plasma membrane vesicles from rat liver

1991 • 132 citations

Differential inhibition by cyclosporins of primary‐active ATP‐dependent transporters in the hepatocyte canalicular membrane

1993 • 128 citations

Restoration of daunomycin retention in multidrug-resistant P388 cells by submicromolar concentrations of SDZ PSC 833, a nonimmunosuppressive cyclosporin derivative

1991 • 126 citations

The Identification of a Distinct Export Step following the Biosynthesis of Leukotriene C4 by Human Eosinophils

1989 • 125 citations

Hepatic Transport and Bile Secretion: Physiology and Pathophysiology

1994 • 111 citations

Leukotrienes: Biosynthesis, transport, inactivation, and analysis

1992 • 90 citations

Purification of human leukotriene C4 synthase.

1992 • 81 citations

Human leukotriene C4 synthase expression in dimethyl sulfoxide-differentiated U937 cells.

1992 • 68 citations

The use of alkaline-phosphatase-conjugated second antibody for the visualization of electrophoretically separated proteins recognized by monoclonal antibodies

1983 • 67 citations

ATP‐dependent leukotriene export from mastocytoma cells

1991 • 64 citations

Leukotriene C4 uses a probenecid-sensitive export carrier that does not recognize leukotriene B4.

1992 • 57 citations

ATP stimulates the uptake of S‐dinitrophenylglutathione by rat liver plasma membrane vesicles

1988 • 57 citations

ATP-dependent multispecific organic anion transport system in rat erythrocyte membrane vesicles

1992 • 56 citations

The 1991 Merck Frosst Award. Multidrug resistance in small cell lung cancer

1992 • 55 citations

[63] Glutathione transferase isoenzymes from rat liver cytosol

1985 • 52 citations

In vivo and in vitro pharmacokinetics and metabolism of vincaalkaloids in rat II. Vinblastine and Vincristine

1990 • 40 citations

Identification of etoposide glucuronide as a major metabolite of etoposide in the rat and rabbit.

1988 • 37 citations

Direct photoaffinity labeling of leukotriene binding sites

1989 • 34 citations

Functional Reconstitution of ATP‐Dependent Transporters from the Solubilized Hepatocyte Canalicular Membrane

1994 • 22 citations

Hepatobiliary elimination of the peroxisome proliferator nafenopin by conjugation and subsequent atp-dependent transport across the canalicular membrane

1994 • 18 citations