Review: Alzheimer's Amyloid β-Peptide-Associated Free Radical Oxidative Stress and Neurotoxicity

Free radicals in biology and medicine

1991 • 17,840 citations

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

Alzheimer's Disease: The Amyloid Cascade Hypothesis

1992 • 6,649 citations

Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes

1991 • 6,550 citations

Critical Stability Constants

1982 • 6,081 citations

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

Free Radicals in Biology and Medicine

1990 • 4,962 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

1991 • 4,120 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Diffusible, nonfibrillar ligands derived from Aβ _1–42 are potent central nervous system neurotoxins

1998 • 3,404 citations

Protein Oxidation and Aging

1992 • 2,687 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Evaluation of the probe 2',7'-dichlorofluorescin as an indicator of reactive oxygen species formation and oxidative stress

1992 • 2,536 citations

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

1992 • 2,520 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease

1997 • 2,394 citations

Oxidative Stress Hypothesis in Alzheimer's Disease

1997 • 2,355 citations

Seeding “one-dimensional crystallization” of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?

1993 • 2,146 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

The carboxy terminus of the .beta. amyloid protein is critical for the seeding of amyloid formation: Implications for the pathogenesis of Alzheimer's disease

1993 • 1,951 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Free Radicals in Biology

1976 • 1,879 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Spin Trapping: ESR parameters of spin adducts 1474 1528V

1987 • 1,660 citations

Two amyloid precursor protein transgenic mouse models with Alzheimer disease-like pathology

1997 • 1,438 citations

Beta-amyloid neurotoxicity requires fibril formation and is inhibited by congo red.

1994 • 1,313 citations

Excess brain protein oxidation and enzyme dysfunction in normal aging and in Alzheimer disease.

1991 • 1,290 citations

Widespread Peroxynitrite-Mediated Damage in Alzheimer’s Disease

1997 • 1,241 citations

Age-related changes in oxidized proteins.

1987 • 1,229 citations

NMDA-dependent superoxide production and neurotoxicity

1993 • 1,188 citations

Oxidative stress: the paradox of aerobic life

1995 • 1,152 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

1999 • 1,070 citations

Amyloid β-Protein Fibrillogenesis

1999 • 1,041 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

1998 • 988 citations

Neurotoxicity of a Fragment of the Amyloid Precursor Associated with Alzheimer's Disease

1989 • 904 citations

Oxidation of methionyl residues in proteins: Tools, targets, and reversal

1995 • 860 citations

In vitro aging of ß-amyloid protein causes peptide aggregation and neurotoxicity

1991 • 833 citations

Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons

1996 • 833 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Advanced glycation end products contribute to amyloidosis in Alzheimer disease.

1994 • 791 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

1995 • 784 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

Oxidative Alterations in Alzheimer's Disease

1999 • 772 citations

Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain

1993 • 759 citations

Alzheimer's Disease: A Central Role for Amyloid

1994 • 749 citations

Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

1999 • 748 citations

Processing of the Amyloid Protein Precursor to Potentially Amyloidogenic Derivatives

1992 • 737 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis

1997 • 727 citations

Advanced Maillard reaction end products are associated with Alzheimer disease pathology.

1994 • 712 citations

Structure‐Activity Analyses of β‐Amyloid Peptides: Contributions of the β25–35 Region to Aggregation and Neurotoxicity

1995 • 691 citations

Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease

1998 • 677 citations

Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease

1995 • 641 citations

APPSW Transgenic Mice Develop Age-related Aβ Deposits and Neuropil Abnormalities, but no Neuronal Loss in CA1

1997 • 640 citations

Protein-bound acrolein: Potential markers for oxidative stress

1998 • 622 citations

Mitochondrial dysfunction in neurodegenerative diseases

1998 • 606 citations

Water-soluble Aβ(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains

1996 • 603 citations

Evidence of neuronal oxidative damage in Alzheimer's disease.

1996 • 602 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

Microglial response to amyloid plaques in APPsw transgenic mice.

1998 • 580 citations

The isoprostanes: Unique bioactive products of lipid peroxidation

1997 • 561 citations

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death

1995 • 559 citations

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

1993 • 557 citations

Amyloid‐β Deposition in Alzheimer Transgenic Mice Is Associated with Oxidative Stress

1998 • 549 citations

Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation

1997 • 543 citations

An Assessment of Oxidative Damage to Proteins, Lipids, and DNA in Brain from Patients with Alzheimer's Disease

1997 • 526 citations

Acrolein Is a Product of Lipid Peroxidation Reaction

1998 • 521 citations

β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease

1993 • 520 citations

Alzheimer Neuropathologic Alterations in Aged Cognitively Normal Subjects

1999 • 518 citations

An in vivo model for the neurodegenerative effects of beta amyloid and protection by substance P.

1991 • 516 citations

Evidence for a membrane defect in Alzheimer disease brain.

1992 • 514 citations

Aging renders the brain vulnerable to amyloid β-protein neurotoxicity

1998 • 513 citations

Increased Peroxidation and Reduced Antioxidant Enzyme Activity in Alzheimer's Disease

1998 • 497 citations

Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease

1996 • 482 citations

Modification of histidine residues in proteins by reaction with 4-hydroxynonenal.

1992 • 481 citations

Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease

1998 • 467 citations

Radical AGEing in Alzheimer's disease

1995 • 464 citations

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

1994 • 462 citations

Autopsy Samples of Alzheimer's Cortex Show Increased Peroxidation In Vitro

1990 • 456 citations

Relative abundance of Alzheimer A beta amyloid peptide variants in Alzheimer disease and normal aging.

1994 • 455 citations

Alzheimer's disease and oxidative stress: implications for novel therapeutic approaches

1999 • 446 citations

Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal

1997 • 440 citations

Potentially Amyloidogenic, Carboxyl-Terminal Derivatives of the Amyloid Protein Precursor

1992 • 432 citations

Regional membrane phospholipid alterations in Alzheimer's disease.

1998 • 422 citations

Formation of Isoprostane-like Compounds (Neuroprostanes) in Vivo from Docosahexaenoic Acid

1998 • 421 citations

Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

1997 • 416 citations

β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease

1994 • 406 citations

Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease

1997 • 403 citations

Protein oxidation and proteolysis during aging and oxidative stress

1989 • 396 citations

Protein‐Bound Acrolein

1999 • 394 citations

Development of Alzheimer-related neurofibrillary changes in the neocortex inversely recapitulates cortical myelogenesis

1996 • 390 citations

Chapter 7 Protein Oxidation Processes in Aging Brain

1997 • 389 citations

Inhibitory sites in enzymes: Zinc removal and reactivation by thionein

1999 • 387 citations

Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease.

1996 • 373 citations

Amyloid-beta aggregation: selective inhibition of aggregation in mixtures of amyloid with different chain lengths

1994 • 370 citations

Secondary structure of amyloid beta peptide correlates with neurotoxic activity in vitro.

1994 • 363 citations

Advances in Alzheimer's disease

1991 • 358 citations

Potent Neuroprotective Properties against the Alzheimer β-Amyloid by an Endogenous Melatonin-related Indole Structure, Indole-3-propionic Acid

1999 • 351 citations

β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease

1997 • 350 citations

RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

1997 • 345 citations

Clusterin (apoJ) Alters the Aggregation of Amyloid β-Peptide (Aβ1-42) and Forms Slowly Sedimenting Aβ Complexes That Cause Oxidative Stress

1995 • 343 citations

Methionine residues may protect proteins from critical oxidative damage

1999 • 335 citations

Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons

1995 • 333 citations

Apolipoprotein E Affects the Rate of Alzheimer Disease Expression: β-Amyloid Burden Is a Secondary Consequence Dependent on APOE Genotype and Duration of Disease

1994 • 332 citations

Discussion

1999 • 331 citations

Presence of soluble amyloid β–peptide precedes amyloid plaque formation in Down's syndrome

1996 • 328 citations

Evidence of oxidative stress and in vivo neurotoxicity of beta-amyloid in a transgenic mouse model of Alzheimer's disease: a chronic oxidative paradigm for testing antioxidant therapies in vivo.

1998 • 327 citations

Membrane Lipids, Selectively Diminished in Alzheimer Brains, Suggest Synapse Loss as a Primary Event in Early‐Onset Form (Type I) and Demyelination in Late‐Onset Form (Type II)

1994 • 321 citations

Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors

1997 • 307 citations

Comparison of Neurodegenerative Pathology in Transgenic Mice Overexpressing V717F β-Amyloid Precursor Protein and Alzheimer’s Disease

1996 • 301 citations

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

1995 • 292 citations

Alzheimer's disease – synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts

1998 • 292 citations

Inhibition of Amyloid β Protein Aggregation and Neurotoxicity by Rifampicin

1996 • 288 citations

Increased DNA Oxidation and Decreased Levels of Repair Products in Alzheimer's Disease Ventricular CSF

1999 • 283 citations

Decreased glutathione transferase activity in brain and ventricular fluid in Alzheimer's disease

1998 • 275 citations

The Lipid Peroxidation Product, 4‐Hydroxy‐2‐trans‐Nonenal, Alters the Conformation of Cortical Synaptosomal Membrane Proteins

1997 • 270 citations

Advanced glycation endproducts in ageing and Alzheimer's disease

1997 • 267 citations

Vitamin E and Alzheimer disease: the basis for additional clinical trials

2000 • 263 citations

Effects of injected Alzheimer beta-amyloid cores in rat brain.

1991 • 255 citations

Decrease in Peptide Methionine Sulfoxide Reductase in Alzheimer's Disease Brain

1999 • 251 citations

Cerebrospinal fluid F₂‐isoprostane levels are increased in Alzheimer's disease

1998 • 241 citations

Free radical oxidation of brain proteins in accelerated senescence and its modulation by N -tert-butyl-α-phenylnitrone

1997 • 234 citations

Vitamin E Prevents Alzheimer's Amyloid ß-Peptide (1-42)-Induced Neuronal Protein Oxidation and Reactive Oxygen Species Production

2000 • 231 citations

Amyloid β Peptide (25–35) Inhibits Na⁺‐Dependent Glutamate Uptake in Rat Hippocampal Astrocyte Cultures

1996 • 225 citations

Modified-Peptide Inhibitors of Amyloid β-Peptide Polymerization

1999 • 216 citations

α ₂ -macroglobulin associates with β-amyloid peptide and prevents fibril formation

1998 • 216 citations

beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger.

1996 • 214 citations

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

1996 • 212 citations

A Critical Review of Spin Trapping in Biological Systems

1980 • 212 citations

Aggregation State and Neurotoxic Properties of Alzheimer Beta-Amyloid Peptide

1995 • 205 citations

Nordihydroguaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation

1994 • 202 citations

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

1990 • 196 citations

Bcl‐2 Protects Isolated Plasma and Mitochondrial Membranes Against Lipid Peroxidation Induced by Hydrogen Peroxide and Amyloid β‐Peptide

1998 • 188 citations

Oxidatively Induced Structural Alteration of Glutamine Synthetase Assessed by Analysis of Spin Label Incorporation Kinetics: Relevance to Alzheimer's Disease

1997 • 187 citations

Oligomerization of Endogenous and Synthetic Amyloid β-Protein at Nanomolar Levels in Cell Culture and Stabilization of Monomer by Congo Red

1998 • 184 citations

Methionine residue 35 is important in amyloid β-peptide-associated free radical oxidative stress

1999 • 171 citations

Alzheimer .beta.-Amyloid Peptide 25-35: Electrostatic Interactions with Phospholipid Membranes

1994 • 171 citations

Peroxynitrite‐Induced Alterations in Synaptosomal Membrane Proteins

1999 • 165 citations

In-vivo glutathione elevation protects against hydroxyl free radical-induced protein oxidation in rat brain

2000 • 164 citations

Metallothionein/disulfide interactions, oxidative stress, and the mobilization of cellular zinc

1995 • 160 citations

ALZHEIMER'S DISEASE AND RELATED DISORDERS

2001 • 158 citations

Amyloid β-peptide polymerization studied using fluorescence correlation spectroscopy

1999 • 156 citations

31P Nuclear Magnetic Resonance Study of the Brain in Alzheimerʼs Disease

1988 • 149 citations

Quantitation of amyloid beta-protein (A beta) in the cortex during aging and in Alzheimer's disease.

1998 • 146 citations

Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration

1999 • 145 citations

Clinical Correlates of Cortical and Nucleus Basalis Pathology in Alzheimer Dementia

1994 • 140 citations

The Expression of Key Oxidative Stress-Handling Genes in Different Brain Regions in Alzheimer's Disease

1998 • 136 citations

Alzheimer's disease: Advances in clinical and basic research

1994 • 134 citations

Low concentrations of estradiol reduce β-amyloid (25–35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells

1997 • 133 citations

Protective effects of asiaticoside derivatives against beta-amyloid neurotoxicity

1999 • 133 citations

4-Hydroxynonenal, a Product of Lipid Peroxidation, Damages Cholinergic Neurons and Impairs Visuospatial Memory in Rats

1998 • 133 citations

E-4-hydroxy-2-nonenal is cytotoxic and cross-links cytoskeletal proteins in P19 neuroglial cultures.

1996 • 132 citations

β‐Amyloid Neurotoxicity In Vitro: Evidence of Oxidative Stress but Not Protection by Antioxidants

1997 • 125 citations

Alzheimer's disease and related disorders

1990 • 125 citations

Free radicals in Alzheimer’s disease

1998 • 123 citations

Protein Oxidation in Aging Braina

1992 • 123 citations

EPR Spin-Trapping Studies of the Hydroxyl Radical Scavenging Activity of Carnosine and Related Dipeptides

1994 • 119 citations

Transgenic mice expressing Alzheimer amyloid precursor proteins

1998 • 119 citations

Alzheimer's disease : advances in clinical and basic research

1993 • 118 citations

β-amyloid peptide in vitro toxicity: Lot-to-lot variability

1992 • 116 citations

Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach

2001 • 114 citations

β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimerʼs disease

1995 • 114 citations

Redox control of secondary structure in a designed peptide

1993 • 113 citations

The antioxidant vitamin E modulates amyloid beta-peptide-induced creatine kinase activity inhibition and increased protein oxidation: implications for the free radical hypothesis of Alzheimer's disease.

1999 • 111 citations

Oxidation of Cytosolic Proteins and Expression of Creatine Kinase BB in Frontal Lobe in Different Neurodegenerative Disorders

1999 • 109 citations

Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach

2013 • 107 citations

Amyloid β‐Peptides Increase Annular and Bulk Fluidity and Induce Lipid Peroxidation in Brain Synaptic Plasma Membranes

1997 • 105 citations

Spin Labeling in Disease

1982 • 104 citations

Alzheimer's Disease Amyloid β Peptide 25-35 Is Localized in the Membrane Hydrocarbon Core: X-Ray Diffraction Analysis

1996 • 103 citations

The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease.

1998 • 102 citations

Vitamin Ε as an Antioxidant/Free Radical Scavenger Against Amyloid β-Peptide-Induced Oxidative Stress in Neocortical Synaptosomal Membranes and Hippocampal Neurons in Culture: Insights into Alzheimer's Disease

1999 • 101 citations

Gluthatione level is altered in lymphoblasts from patients with familial Alzheimer's disease

1999 • 100 citations

[48] Amyloid β-peptide-associated free radical oxidative stress, neurotoxicity, and Alzheimer's disease

1999 • 100 citations

The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease.

1999 • 97 citations

Brain membrane fluidity and lipid peroxidation in Alzheimer's disease

1990 • 95 citations

Electron paramagnetic resonance investigations of free radical-induced alterations in neocortical synaptosomal membrane protein infrastructure

1994 • 95 citations

Alzheimer's amyloid β-peptide associated free radicals increase rat embryonic neuronal polyamine uptake and ornithine decarboxylase activity: protective effect of vitamin E

1999 • 95 citations

Amyloid β Peptides Do Not Form Peptide-derived Free Radicals Spontaneously, but Can Enhance Metal-catalyzed Oxidation of Hydroxylamines to Nitroxides

1999 • 94 citations

Increased Susceptibility of Alzheimer's Disease Temporal Cortex to Oxygen Free Radical-Mediated Processes

1997 • 91 citations

Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease

1997 • 91 citations

Inhibitors of free radical formation fail to attenuate direct β‐amyloid_25–35 peptide‐mediated neurotoxicity in rat hippocampal cultures

1994 • 89 citations

Altered energy metabolism in Alzheimer's disease

1996 • 89 citations

3-Nitropropionic acid induced in vivo protein oxidation in striatal and cortical synaptosomes: insights into Huntington's disease

2000 • 86 citations

Role of spermine in amyloid ?-peptide-associated free radical-induced neurotoxicity

2001 • 85 citations

β-Amyloid toxicity in organotypic cultures : protection by EUK-8, a synthetic catalytic free radical scavenger

1996 • 85 citations

Protease inhibitor coinfusion with amyloid beta-protein results in enhanced deposition and toxicity in rat brain.

1998 • 85 citations

Melatonin prevents β‐amyloid‐induced lipid peroxidation

1998 • 83 citations

Actions of Neurotoxic β‐Amyloid on Calcium Homeostasis and Viability of PC12 Cells Are Blocked by Antioxidants but Not by Calcium Channel Antagonists

1996 • 81 citations

Oxidative Modification of Glutamine Synthetase by Amyloid Beta Peptide

1997 • 80 citations

Vitamin E protects against Alzheimer's amyloid peptide (25–35)-induced changes in neocortical synaptosomal membrane lipid structure and composition

1998 • 78 citations

Glutathione transferase protects neuronal cultures against four hydroxynonenal toxicity

1998 • 76 citations

Prevention of Hyperoxia‐Induced Alterations in Synaptosomal Membrane‐Associated Proteins by N‐tert‐Butyl‐α‐Phenylnitrone and 4‐Hydroxy‐2,2,6,6‐Tetramethylpiperidin‐1‐oxyl (Tempol)

1996 • 74 citations

Chapter 26 Reduced neuronal activity and reactivation in Alzheimer's disease

1998 • 74 citations

Structural Characterization of Arachidonyl Radicals Formed by Prostaglandin H Synthase-2 and Prostaglandin H Synthase-1 Reconstituted with Mangano Protoporphyrin IX

1998 • 74 citations

Ischemia/reperfusion-induced changes in membrane proteins and lipids of gerbil cortical synaptosomes

1995 • 72 citations

Coupling of ml Muscarinic Receptors to G Protein in Alzheimer Disease

1991 • 65 citations

Side Chain Fragmentation of N-Terminal Threonine or Serine Residue Induced through Intramolecular Proton Transfer to Hydroxy Sulfuranyl Radical Formed at Neighboring Methionine in Dipeptides

1994 • 64 citations

β-Amyloid-induced toxicity in rat hippocampal cells: In vitro evidence for the involvement of free radicals

1995 • 63 citations

Protease Inhibitor Coinfusion with Amyloid β-Protein Results in Enhanced Deposition and Toxicity in Rat Brain

1998 • 62 citations

Relationships between cell density, glutathione and proliferation of A549 human lung adenocarcinoma cells treated with acrolein

1997 • 62 citations

Glutamine Synthetase‐Induced Enhancement of β‐Amyloid Peptide Aβ(1–40) Neurotoxicity Accompanied by Abrogation of Fibril Formation and Aβ Fragmentation

1996 • 61 citations

Temporal Relations Among Amyloid β-Peptide-Induced Free-Radical Oxidative Stress, Neuronal Toxicity, and Neuronal Defensive Responses

1998 • 61 citations

Aβ(25–35) peptide displays H2O2-like reactivity towards aqueous FE2+, nitroxide spin probes, Ant) synaptosomal membrane proteins

1995 • 59 citations

Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal Neurons

1995 • 57 citations

Enhanced Phosphodiestric Breakdown of Phosphatidylinositol Bisphosphate After Experimental Brain Injury

1994 • 57 citations

In vivo modulation of rodent glutathione and its role in peroxynitrite-induced neocortical synaptosomal membrane protein damage

1999 • 54 citations

Eicosanoids and Isoeicosanoids: Indices of Cellular Function and Oxidant Stress ,

1998 • 53 citations

Characterization of 8‐Epiprostaglandin F_2α as aMarker of Amyloid β‐Peptide‐Induced Oxidative Damage

1999 • 46 citations

Disruption of Brain Cell Ion Homeostasis in Alzheimer's Disease by Oxy Radicals, and Signaling Pathways That Protect Therefrom

1997 • 45 citations

Amyloid β-peptide(1–40)-mediated oxidative stress in cultured hippocampal neurons

1998 • 43 citations

Inhibition of Age-Induced β-Amyloid Neurotoxicity in Rat Hippocampal Cells

1996 • 42 citations

α-1-Antichymotrypsin interaction with Aβ (1–40) inhibits fibril formation but does not affect the peptide toxicity

1996 • 41 citations

Increased immunostaining for l-ornithine decarboxylase occurs in neocortical neurons of Alzheimer's disease patients

1995 • 41 citations

Oxidativer Streß in der Pathogenese von Morbus Alzheimer und antioxidative Neuroprotektion

1998 • 39 citations

Enhancement of β‐Amyloid Peptide Aβ(1–40)‐Mediated Neurotoxicity by Glutamine Synthetase

1995 • 38 citations

Amyloid β-peptide spin trapping I

1995 • 38 citations

Free radicals and lipid peroxidation do not mediate β-amyloid-induced neuronal cell death

1999 • 38 citations

Effect of lipopolysaccharide on the physical conformation of the erythrocyte cytoskeletal proteins

1995 • 36 citations

A model for beta-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: implications of "molecular shrapnel" for Alzheimer's disease.

1995 • 36 citations

Amyloid β-peptide spin trapping II

1995 • 35 citations

Pathogenesis of Decreased Glucose Turnover and Oxidative Phosphorylation in Ischemic and Trauma‐Induced Dementia of the Alzheimer Type

1997 • 34 citations

Prevention of ischemia/reperfusion-induced alterations in synaptosomal membrane-associated proteins and lipids by N-tert-butyl-α-phenylnitrone and difluoromethylornithine

1995 • 33 citations

Effect of 2-cyclohexene-1-one-induced glutathione diminution on ischemia/reperfusion-induced alterations in the physical state of brain synaptosomal membrane proteins and lipids

1997 • 33 citations

Expression of heat shock genes in fetal and maternal rabbit brain

1985 • 32 citations

Alzheimerʼs β-amyloid peptide is conformationally modified by apolipoprotein E in vitro

1996 • 32 citations

The acute neurotoxic effect of β-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F

1994 • 30 citations

The role of the amyloid protein precursor (APP) in Alzheimer's disease: does the normal function of APP explain the topography of neurodegeneration?

1998 • 30 citations

Lipid Peroxide Overcomes the Inability of Platelet Secretory Phospholipase A2 to Hydrolyze Membrane Phospholipids in Rabbit Platelets

1997 • 28 citations

Membrane structure in disease and drug therapy

2001 • 28 citations

Phenyl N-Tert-Butyl Nitrone Forms Nitric Oxide as a Result of Its Fe(Iii)-Catalyzed Hydrolysis Or Hydroxyl Radical Adduct Formation

1995 • 27 citations

Age and regional structural characterization of lipid hydrocarbon chains from human lenses by infrared, and near-infrared raman, spectroscopies

1998 • 26 citations

Decreased Level of Creatine Kinase BB in the Frontal Cortex of Alzheimer Patients

1992 • 23 citations

THIS ARTICLE HAS BEEN RETRACTED: Diminished Glutathione Levels Cause Spontaneous and Mitochondria‐Mediated Cell Death in Neurons from Trisomy 16 Mice:

2000 • 23 citations

Pharmacological comparison of UTP‐ and thapsigargin‐induced arachidonic acid release in mouse RAW 264.7 macrophages

1998 • 22 citations

Do Endogenous Volatile Organic Chemicals Measured in Breath Reflect and Maintain CYP2E1 Levelsin Vivo?

1997 • 21 citations

Structural alterations in synaptosomal membrane-associated proteins and lipids by transient middle cerebral artery occlusion in the cat

1995 • 20 citations

β-amyloid-Derived Free Radical Oxidation: A Fundamental Process in Alzheimers Disease

2003 • 20 citations

Membrane Structure in Disease and Drug Therapy

2000 • 19 citations

Age and regional structural characterization of lipid hydrocarbon chains from human lenses by infrared, and near‐infrared raman, spectroscopies

1996 • 18 citations

Binding of amyloid beta-protein to intracellular brain proteins in rat and human.

1998 • 17 citations

VULNERABLE NEURONS IN ALZHEIMER DISEASE ACCUMULATE MITOCHONDRIAL DNA WITH THE COMMON 5KB DELETION

1998 • 13 citations

Modifications of Neurofilament Proteins by Possible Metabolites of Allyl Chloride in Vitro

1995 • 13 citations

ACCUMULATION OF 8-HYDROXY-GUANOSINE IN NEURONAL CYTOPLASM INDICATES MITOCHONDRIAL DAMAGE AND RADICAL PRODUCTION ARE EARLY FEATURES OF ALZHEIMER DISEASE

1998 • 13 citations

Strategic Thoughts on the Alzheimer’s Disease Amyloid Protein Precursor: The Way Forward

1994 • 7 citations

Alzheimer's amyloid β-peptide (1–42)-induced oxidative stress and neurotoxicity: Role of methionine residue 35 and CU(II) and prevention by vitamin E

2000 • 4 citations

Alzheimer’s Amyloid β-Peptide-Associated Oxidative Stress: Brain Membrane Lipid Peroxidation and Protein Oxidation

2000 • 1 citations

Deleted Work

1955 • 0 citations