The expression of several mitochondrial and nuclear genes encoding the subunits of electron transport chain enzyme complexes, cytochrome c oxidase, and NADH dehydrogenase, in different brain regions in Alzheimer's disease.

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

1997 • 71,835 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Clinical diagnosis of Alzheimer's disease

1984 • 27,279 citations

Sequence and organization of the human mitochondrial genome

1981 • 9,348 citations

A Laboratory manual

1989 • 6,833 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

The molecular pathology of Alzheimer's disease

1991 • 2,603 citations

Diagnosis of Alzheimer's Disease

1985 • 2,482 citations

Oxidative Stress Hypothesis in Alzheimer's Disease

1997 • 2,355 citations

Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease

1994 • 1,020 citations

Cytochrome oxidase deficiency in Alzheimer's disease

1990 • 581 citations

Brain Cytochrome Oxidase in Alzheimer's Disease

1992 • 526 citations

Cortical Cytochrome Oxidase Activity Is Reduced in Alzheimer's Disease

1994 • 502 citations

Electron transport chain defects in Alzheimer's disease brain

1994 • 483 citations

Increased Nuclear DNA Oxidation in the Brain in Alzheimer's Disease

1998 • 467 citations

Mitochondria, free radicals, and neurodegeneration

1996 • 425 citations

Consensus recommendations for the postmortem diagnosis of Alzheimer's disease. The National Institute on Aging, and Reagan Institute Working Group on Diagnostic Criteria for the Neuropathological Assessment of Alzheimer's Disease.

1997 • 419 citations

Bioenergetic and oxidative stress in neurodegenerative diseases

1995 • 365 citations

Energy Thresholds in Brain Mitochondria

1998 • 354 citations

β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease

1997 • 350 citations

RETRACTED: Mutations in mitochondrial cytochrome c oxidase genes segregate with late-onset Alzheimer disease

1997 • 345 citations

The presence of nucleosomes on a DNA template prevents initiation by RNA polymerase II in vitro

1986 • 339 citations

Calcium Homeostasis and Reactive Oxygen Species Production in Cells Transformed by Mitochondria from Individuals with Sporadic Alzheimer’s Disease

1997 • 253 citations

Mitochondrial membrane fluidity and oxidative damage to mitochondrial DNA in aged and AD human brain

1997 • 211 citations

Sequences of 20 subunits of NADH: Ubiquinone oxidoreductase from bovine heart mitochondria

1992 • 180 citations

Alzheimer's Disease Brain: Alterations in RNA Levels and in a Ribonuclease-Inhibitor Complex

1984 • 173 citations

Structure and assembly of cytochrome c oxidase

1990 • 145 citations

Apparent mtDNA heteroplasmy in Alzheimer’s disease patients and in normals due to PCR amplification of nucleus-embedded mtDNA pseudogenes

1997 • 137 citations

The Expression of Key Oxidative Stress-Handling Genes in Different Brain Regions in Alzheimer's Disease

1998 • 136 citations

Cytochrome C Oxidase in Alzheimer's Disease Brain

1995 • 135 citations

Cytochrome oxidase in Alzheimer's disease: Biochemical, histochemical, and immunohistochemical analyses of the visual and other systems

1997 • 120 citations

Down-regulation of Mammalian Mitochondrial RNAs During Oxidative Stress

1997 • 119 citations

Human Diseases with Defects in Oxidative Phosphorylation. 2. F1F0 ATP-Synthase Defects in Alzheimer Disease Revealed by Blue Native Polyacrylamide Gel Electrophoresis

1995 • 117 citations

Evidence for Physiological Down-regulation of Brain Oxidative Phosphorylation in Alzheimer's Disease

1996 • 116 citations

Distribution of brain cytochrome oxidase activity in various neurodegenerative diseases

1995 • 109 citations

Functional Alterations in Alzheimer's Disease: Selective Loss of Mitochondrial-encoded Cytochrome Oxidase mRNA in the Hippocampal Formation

1994 • 107 citations

Lack of assembly of mitochondrial DNA-encoded subunits of respiratory NADH dehydrogenase and loss of enzyme activity in a human cell mutant lacking the mitochondrial ND4 gene product.

1993 • 104 citations

Decreased expression of nuclear and mitochondrial DNA-encoded genes of oxidative phosphorylation in association neocortex in Alzheimer disease

1997 • 91 citations

Selective messenger RNA reduction in Alzheimer's disease

1988 • 90 citations

Functional Alterations in Alzheimerʼs Disease

1993 • 88 citations

Cytochrome c oxidase: structure, function, and membrane topology of the polypeptide subunits

1991 • 88 citations

Free radical theory of aging: Alzheimer’s disease pathogenesis

1995 • 86 citations

Characterization of Messenger RNA from the Cerebral Cortex of Control and Alzheimer‐Afflicted Brain

1986 • 80 citations

Differential susceptibility of human skeletal muscle proteins to free radical induced oxidative damage: a histochemical, immunocytochemical and electron microscopical study in vitro

1996 • 79 citations

Changes in Chromatin Structure Associated with Alzheimer's Disease

1981 • 78 citations

Probing a Role of Subunit IV of the -type Ubiquinol Oxidase by Deletion and Cross-linking Analyses

1996 • 75 citations

Brain Energy Metabolizing Enzymes in Alzheimer's Disease: α‐Ketoglutarate Dehydrogenase Complex and Cytochrome Oxidase^a

1997 • 69 citations

Brain Energy Metabolism, Cognitive Function and Down-regulated Oxidative Phosphorylation in Alzheimer Disease

1996 • 65 citations

Regulation of the expression of mitochondrial proteins: relationship between mtDNA copy number and cytochrome-c oxidase activity in human cells and tissues

1993 • 58 citations

Recovery and measurement of specific RNA species from postmortem brain tissue: A general reduction in Alzheimer's disease detected by molecular hybridization

1986 • 55 citations

Gene expression of ND4, a subunit of complex I of oxidative phosphorylation in mitochondria, is decreased in temporal cortex of brains of Alzheimer's disease patients

1996 • 51 citations

Quantitative cytochemistry of cytochrome oxidase and cellular morphometry of the human inferior colliculus in control and Alzheimer's patients

1997 • 44 citations

Pathogenesis of Decreased Glucose Turnover and Oxidative Phosphorylation in Ischemic and Trauma‐Induced Dementia of the Alzheimer Type

1997 • 34 citations

Mitochondrial- and nuclear-encoded subunits of cytochrome oxidase in neurons: Differences in compartmental distribution, correlation with enzyme activity, and regulation by neuronal activity

1996 • 26 citations

Role of Nuclear-Encoded Subunits of Mitochondrial Cytochrome c Oxidase in Proton Pumping Revealed by Limited Enzymic Proteolysis

1994 • 22 citations