β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease

Free Radicals in Biology and Medicine

1990 • 4,962 citations

Personal Communication

1997 • 2,763 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Oxidative Stress in Neurodegenerative Diseases

1996 • 1,336 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Amyloid β-Protein and the Genetics of Alzheimer's Disease

1996 • 794 citations

Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation

1995 • 784 citations

Alzheimer's Disease: A Central Role for Amyloid

1994 • 749 citations

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha-phenylnitrone.

1991 • 734 citations

Neurotrophic Factors Attenuate Glutamate‐Induced Accumulation of Peroxides, Elevation of Intracellular Ca²⁺ Concentration, and Neurotoxicity and Increase Antioxidant Enzyme Activities in Hippocampal Neurons

1995 • 616 citations

Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes

1994 • 462 citations

Secreted Forms of β-Amyloid Precursor Protein Protect Hippocampal Neurons against Amyloid β-Peptide-Induced Oxidative Injury

1994 • 445 citations

Peroxynitrite‐Induced Cytotoxicity in PC12 Cells: Evidence for an Apoptotic Mechanism Differentially Modulated by Neurotrophic Factors

1995 • 292 citations

Inhibition of Amyloid β Protein Aggregation and Neurotoxicity by Rifampicin

1996 • 288 citations

Alzheimer's disease: Advances in clinical and basic research

1994 • 134 citations

Detection of alkyl, alkoxyl, and alkyperoxyl radicals from the thermolysis of azobis(isobutyronitrile) by ESR/spin trapping. Evidence for double spin adducts from liquid-phase chromatography and mass spectroscopy

1990 • 118 citations

Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach

2001 • 114 citations

β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimerʼs disease

1995 • 114 citations

Oxygen Radicals and the Disease Process

1998 • 108 citations

Alzheimer's Disease Amyloid β Peptide 25-35 Is Localized in the Membrane Hydrocarbon Core: X-Ray Diffraction Analysis

1996 • 103 citations

Induction of Superoxide Anion and Nitric Oxide Production in Cultured Microglia^a

1994 • 94 citations

Inhibitors of free radical formation fail to attenuate direct β‐amyloid_25–35 peptide‐mediated neurotoxicity in rat hippocampal cultures

1994 • 89 citations

Prevention of Hyperoxia‐Induced Alterations in Synaptosomal Membrane‐Associated Proteins by N‐tert‐Butyl‐α‐Phenylnitrone and 4‐Hydroxy‐2,2,6,6‐Tetramethylpiperidin‐1‐oxyl (Tempol)

1996 • 74 citations

Glutamine Synthetase‐Induced Enhancement of β‐Amyloid Peptide Aβ(1–40) Neurotoxicity Accompanied by Abrogation of Fibril Formation and Aβ Fragmentation

1996 • 61 citations

Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal Neurons

1995 • 57 citations

Kinetics and Mechanism of Iron(III) Removal from Citrate by Desferrioxamine B and 3-Hydroxy-1,2-Dimethyl-4-Pyridone

1994 • 51 citations

Inhibition of Age-Induced β-Amyloid Neurotoxicity in Rat Hippocampal Cells

1996 • 42 citations

α-1-Antichymotrypsin interaction with Aβ (1–40) inhibits fibril formation but does not affect the peptide toxicity

1996 • 41 citations

Biofunctional membranes: an EPR study of active site structure and stability of papain non-covalently immobilized on the surface of modified poly(ether) sulfone membranes through the avidin-biotin linkage

1996 • 38 citations

Enhancement of β‐Amyloid Peptide Aβ(1–40)‐Mediated Neurotoxicity by Glutamine Synthetase

1995 • 38 citations

Effect of lipopolysaccharide on the physical conformation of the erythrocyte cytoskeletal proteins

1995 • 36 citations

Effect of 2-cyclohexene-1-one-induced glutathione diminution on ischemia/reperfusion-induced alterations in the physical state of brain synaptosomal membrane proteins and lipids

1997 • 33 citations

The acute neurotoxic effect of β-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F

1994 • 30 citations

Spin Labeling of Membrane Proteins in Mammalian Brain Synaptic Plasma Membranes: Partial Characterization

1992 • 28 citations

Alpha 1-antichymotrypsin interaction with A beta (1-42) does not inhibit fibril formation but attenuates the peptide toxicity.

1996 • 21 citations

α1-Antichymotrypsin interaction with Aβ(1–42) does not inhibit fibril formation but attenuates the peptide toxicity

1996 • 16 citations