Amyloid-β peptide–Receptor for Advanced Glycation Endproduct interaction elicits neuronal expression of macrophage-colony stimulating factor: A proinflammatory pathway in Alzheimer disease

Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity

2012 • 8,865 citations

Adhesion receptors of the immune system

1990 • 6,585 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

1996 • 4,118 citations

Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.

1991 • 3,819 citations

Oxidative Stress, Glutamate, and Neurodegenerative Disorders

1993 • 3,746 citations

Secreted amyloid β–protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

1996 • 2,543 citations

Alzheimer-type neuropathology in transgenic mice overexpressing V717F β-amyloid precursor protein

1995 • 2,456 citations

Hydrogen peroxide mediates amyloid β protein toxicity

1994 • 2,065 citations

Neurotrophic and Neurotoxic Effects of Amyloid β Protein: Reversal by Tachykinin Neuropeptides

1990 • 1,975 citations

RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease

1996 • 1,955 citations

The Human Hematopoietic Colony-Stimulating Factors

1987 • 1,728 citations

NF-κB: A pleiotropic mediator of inducible and tissue-specific gene control

1989 • 1,622 citations

Neurodegeneration induced by beta-amyloid peptides in vitro: the role of peptide assembly state

1993 • 1,422 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

1995 • 1,116 citations

A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.

1994 • 1,085 citations

Vascular cell adhesion molecule-1 (VCAM-1) gene transcription and expression are regulated through an antioxidant-sensitive mechanism in human vascular endothelial cells.

1993 • 1,079 citations

Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse.

1990 • 1,012 citations

Advanced glycation endproducts interacting with their endothelial receptor induce expression of vascular cell adhesion molecule-1 (VCAM-1) in cultured human endothelial cells and in mice. A potential mechanism for the accelerated vasculopathy of diabetes.

1995 • 886 citations

Cellular processing of β-amyloid precursor protein and the genesis of amyloid β-peptide

1993 • 809 citations

Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues.

1993 • 764 citations

Factors regulating macrophage production and growth. Purification and some properties of the colony stimulating factor from medium conditioned by mouse L cells.

1977 • 740 citations

Scavenger receptor-mediated adhesion of microglia to β-amyloid fibrils

1996 • 726 citations

beta-Amyloid-(1-42) is a major component of cerebrovascular amyloid deposits: implications for the pathology of Alzheimer disease.

1993 • 713 citations

Microglia in degenerative neurological disease

1993 • 594 citations

Vitamin E protects nerve cells from amyloid βprotein toxicity

1992 • 583 citations

Glycated tau protein in Alzheimer disease: a mechanism for induction of oxidant stress.

1994 • 558 citations

Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells [published erratum appears in Blood 1990 Dec 1;76(11):2420]

1990 • 540 citations

Endothelial nuclear factor-kappa B and the initiation of the atherosclerotic lesion.

1993 • 525 citations

Functional analysis of the human vascular cell adhesion molecule 1 promoter.

1992 • 442 citations

Heme oxygenase-1 is associated with the neurofibrillary pathology of Alzheimer's disease.

1994 • 420 citations

Non-enzymatically glycated tau in Alzheimer's disease induces neuronal oxidant stress resulting in cytokine gene expression and release of amyloid β-peptide

1995 • 401 citations

An immortalized cell line expresses properties of activated microglial cells

1992 • 356 citations

Divalent cation-independent macrophage adhesion inhibited by monoclonal antibody to murine scavenger receptor

1993 • 348 citations

β-Amyloid stimulates glial cells in vitro to produce growth factors that accumulate in senile plaques in Alzheimer's disease

1992 • 291 citations

Involvement of free radicals in dementia of the Alzheimer type: A hypothesis

1990 • 191 citations

Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

1995 • 187 citations

Amyloid beta-protein as a substrate interacts with extracellular matrix to promote neurite outgrowth.

1993 • 179 citations

Activation of Macrophages by Alzheimer β Amyloid Peptide

1994 • 175 citations

Brain Expression of Apolipoproteins E, J, and A‐I in Alzheimer's Disease

1996 • 174 citations

Is Alzheimer's disease an apolipoprotein E amyloidosis?

1995 • 156 citations

Expression of the macrophage scavenger receptor, a multifunctional lipoprotein receptor, in microglia associated with senile plaques in Alzheimer's disease.

1996 • 152 citations

Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis

1994 • 151 citations

The Interaction between Apolipoprotein E and Alzheimer's Amyloid β-Peptide Is Dependent on β-Peptide Conformation

1996 • 129 citations

ApoE immunoreactivity and microglial cells in Alzheimer's disease brain

1995 • 122 citations

Transcriptional Activation of the Macrophage-Colony Stimulating Factor Gene by Minimally Modified LDL

1995 • 99 citations

The amyloid beta-protein of Alzheimer's disease is chemotactic for mononuclear phagocytes

1992 • 94 citations

Inhibitors of free radical formation fail to attenuate direct β‐amyloid_25–35 peptide‐mediated neurotoxicity in rat hippocampal cultures

1994 • 89 citations

Colony‐stimulating factor‐1 receptor (c‐fms)

1988 • 55 citations

Searching for Drugs That Combat Alzheimer's

1996 • 50 citations

The Alzheimer's disease sphinx: a riddle with plaques and tangles.

1994 • 34 citations

Clinical and Neuropathological Correlates of Apolipoprotein E Genotype in Alzheimer's Disease ‐ Window on Molecular Epidemiologya

1996 • 31 citations