The free radical antioxidant vitamin E protects cortical synaptosomal membranes from amyloid beta-peptide(25-35) toxicity but not from hydroxynonenal toxicity: relevance to the free radical hypothesis of Alzheimer's disease.
Data up to Jan 2025
Total Citations Per Year
Abstract
References (56)
Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays
1983 • 52,849 citations
Free radicals in biology and medicine
1991 • 17,840 citations
Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes
1991 • 6,550 citations
Protein Oxidation and Aging
1992 • 2,687 citations
A Controlled Trial of Selegiline, Alpha-Tocopherol, or Both as Treatment for Alzheimer's Disease
1997 • 2,394 citations
Oxidative Stress Hypothesis in Alzheimer's Disease
1997 • 2,355 citations
Hydrogen peroxide mediates amyloid β protein toxicity
1994 • 2,065 citations
A model for beta-amyloid aggregation and neurotoxicity based on free radical generation by the peptide: relevance to Alzheimer disease.
1994 • 1,085 citations
Oxidative stress and the pathogenesis of Parkinson's disease
1996 • 967 citations
Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides
1996 • 876 citations
Estrogens Attenuate and Corticosterone Exacerbates Excitotoxicity, Oxidative Injury, and Amyloid β‐Peptide Toxicity in Hippocampal Neurons
1996 • 833 citations
Amyloid β-Protein and the Genetics of Alzheimer's Disease
1996 • 794 citations
Brain Regional Correspondence Between Alzheimer's Disease Histopathology and Biomarkers of Protein Oxidation
1995 • 784 citations
A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide
1997 • 779 citations
Evidence that 4-Hydroxynonenal Mediates Oxidative Stress-Induced Neuronal Apoptosis
1997 • 727 citations
Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer's disease
1995 • 641 citations
17-β Estradiol Protects Neurons from Oxidative Stress-Induced Cell Death in Vitro
1995 • 612 citations
Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death
1995 • 559 citations
Amyloid β-Peptide Impairs Glucose Transport in Hippocampal and Cortical Neurons: Involvement of Membrane Lipid Peroxidation
1997 • 543 citations
β-Amyloid precursor protein metabolites and loss of neuronal Ca2+ homeostasis in Alzheimer's disease
1993 • 520 citations
Impairment of Glucose and Glutamate Transport and Induction of Mitochondrial Oxidative Stress and Dysfunction in Synaptosomes by Amyloid β‐Peptide: Role of the Lipid Peroxidation Product 4‐Hydroxynonenal
1997 • 440 citations
β-Amyloid Peptide Free Radical Fragments Initiate Synaptosomal Lipoperoxidation in a Sequence-Specific Fashion: Implications to Alzheimer′s Disease
1994 • 406 citations
Elevated 4-Hydroxynonenal in Ventricular Fluid in Alzheimer’s Disease
1997 • 403 citations
Chapter 7 Protein Oxidation Processes in Aging Brain
1997 • 389 citations
Advances in Alzheimer's disease
1991 • 358 citations
β-Amyloid-Associated Free Radical Oxidative Stress and Neurotoxicity: Implications for Alzheimer's Disease
1997 • 350 citations
Direct evidence of oxidative injury produced by the Alzheimer's β-Amyloid peptide (1–40) in cultured hippocampal neurons
1995 • 333 citations
Inhibition of Amyloid β Protein Aggregation and Neurotoxicity by Rifampicin
1996 • 288 citations
The Lipid Peroxidation Product, 4‐Hydroxy‐2‐trans‐Nonenal, Alters the Conformation of Cortical Synaptosomal Membrane Proteins
1997 • 270 citations
Free radical oxidation of brain proteins in accelerated senescence and its modulation by N -tert-butyl-α-phenylnitrone
1997 • 234 citations
Amyloid β Peptide (25–35) Inhibits Na+‐Dependent Glutamate Uptake in Rat Hippocampal Astrocyte Cultures
1996 • 225 citations
beta-Amyloid toxicity in organotypic hippocampal cultures: protection by EUK-8, a synthetic catalytic free radical scavenger.
1996 • 214 citations
The Intracellular Component of Cellular 3‐(4,5‐Dimethylthiazol‐2‐yl)‐2,5‐Diphenyltetrazolium Bromide (MTT) Reduction Is Specifically Inhibited by β‐Amyloid Peptides
1995 • 204 citations
Nordihydroguaiaretic acid protects hippocampal neurons against amyloid β-peptide toxicity, and attenuates free radical and calcium accumulation
1994 • 202 citations
Bcl‐2 Protects Isolated Plasma and Mitochondrial Membranes Against Lipid Peroxidation Induced by Hydrogen Peroxide and Amyloid β‐Peptide
1998 • 188 citations
Oxidatively Induced Structural Alteration of Glutamine Synthetase Assessed by Analysis of Spin Label Incorporation Kinetics: Relevance to Alzheimer's Disease
1997 • 187 citations
Protective effect of transforming growth factor-beta 1 on beta-amyloid neurotoxicity in rat hippocampal neurons.
1996 • 163 citations
4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, Impairs Signal Transduction Associated with Muscarinic Acetylcholine and Metabotropic Glutamate Receptors: Possible Action on Gαq/11
1997 • 134 citations
Increased antioxidant enzyme activity in amyloid beta protein-resistant cells
1996 • 128 citations
Mitochondria and free radicals in neurodegenerative diseases
1997 • 124 citations
Reactive Oxygen Species as Causal Agents in the Neurotoxicity of the Alzheimer's Disease‐Associated Amyloid Beta Peptidea
1996 • 116 citations
β-Amyloid peptide-derived, oxygen-dependent free radicals inhibit glutamate uptake in cultured astrocytes: implications for Alzheimerʼs disease
1995 • 114 citations
Electron paramagnetic resonance investigations of free radical-induced alterations in neocortical synaptosomal membrane protein infrastructure
1994 • 95 citations
Oxidative Modification of Glutamine Synthetase by Amyloid Beta Peptide
1997 • 80 citations
Vitamin E protects against Alzheimer's amyloid peptide (25–35)-induced changes in neocortical synaptosomal membrane lipid structure and composition
1998 • 78 citations
Prevention of Hyperoxia‐Induced Alterations in Synaptosomal Membrane‐Associated Proteins by N‐tert‐Butyl‐α‐Phenylnitrone and 4‐Hydroxy‐2,2,6,6‐Tetramethylpiperidin‐1‐oxyl (Tempol)
1996 • 74 citations
Ischemia/reperfusion-induced changes in membrane proteins and lipids of gerbil cortical synaptosomes
1995 • 72 citations
β-Amyloid-induced toxicity in rat hippocampal cells: In vitro evidence for the involvement of free radicals
1995 • 63 citations
Glutamine Synthetase‐Induced Enhancement of β‐Amyloid Peptide Aβ(1–40) Neurotoxicity Accompanied by Abrogation of Fibril Formation and Aβ Fragmentation
1996 • 61 citations
Inhibition of Age-Induced β-Amyloid Neurotoxicity in Rat Hippocampal Cells
1996 • 42 citations
Amyloid β-peptide spin trapping I
1995 • 38 citations
Prevention of ischemia/reperfusion-induced alterations in synaptosomal membrane-associated proteins and lipids by N-tert-butyl-α-phenylnitrone and difluoromethylornithine
1995 • 33 citations
Effect of 2-cyclohexene-1-one-induced glutathione diminution on ischemia/reperfusion-induced alterations in the physical state of brain synaptosomal membrane proteins and lipids
1997 • 33 citations
The acute neurotoxic effect of β-amyloid on mature cultures of rat hippocampal neurons is attenuated by the anti-oxidant U-78517F
1994 • 30 citations
Principles of biological membrane structure: Alteration of the physical state of one side of the membrane by modulation of the physical state of the op
1990 • 30 citations
β-amyloid-Derived Free Radical Oxidation: A Fundamental Process in Alzheimers Disease
2003 • 20 citations