Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Rapid induction of Alzheimer A beta amyloid formation by zinc

1994 • 1,483 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

The Wilson disease gene is a copper transporting ATPase with homology to the Menkes disease gene

1993 • 1,345 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Iron accumulation in Alzheimer disease is a source of redox-generated free radicals

1997 • 1,304 citations

Acute Phase Proteins with Special Reference to C-Reactive Protein and Related Proteins (Pentaxins) and Serum Amyloid A Protein

1983 • 1,283 citations

The cellular prion protein binds copper in vivo

1997 • 1,263 citations

Neurobiology of Zinc and Zinc-Containing Neurons

1989 • 1,075 citations

Assembly and aggregation properties of synthetic Alzheimer's A4/beta amyloid peptide analogs.

1992 • 982 citations

Apolipoprotein E allele–specific antioxidant activity and effects on cytotoxicity by oxidative insults and β–amyloid peptides

1996 • 876 citations

Reduction of β‐amyloid peptide₄₂ in the cerebrospinal fluid of patients with Alzheimer's disease

1995 • 684 citations

Solution conformations and aggregational properties of synthetic amyloid β-peptides of Alzheimer's disease

1992 • 618 citations

Water-soluble Aβ(N-40, N-42) Oligomers in Normal and Alzheimer Disease Brains

1996 • 603 citations

Beta amyloid protein deposition in the brain after severe head injury: implications for the pathogenesis of Alzheimer's disease.

1994 • 563 citations

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

1993 • 557 citations

Solution Structures of β Peptide and Its Constituent Fragments: Relation to Amyloid Deposition

1991 • 531 citations

Morphology and Toxicity of Aβ-(1-42) Dimer Derived from Neuritic and Vascular Amyloid Deposits of Alzheimer's Disease

1996 • 482 citations

Analysis of Heterogeneous βA4 Peptides in Human Cerebrospinal Fluid and Blood by a Newly Developed Sensitive Western Blot Assay

1996 • 477 citations

Biochemistry of Copper

1991 • 473 citations

βA4 amyloid protein deposition in brain after head trauma

1991 • 465 citations

Alzheimer's disease amyloidogenic glycoprotein: expression pattern in rat brain suggests a role in cell contact.

1988 • 444 citations

Amyloid β-protein deposition in tissues other than brain in Alzheimer's disease

1989 • 433 citations

pH-dependent structural transitions of Alzheimer amyloid peptides

1991 • 376 citations

Amyloid β protein (Aβ) deposition: Aβ42(43) precedes Aβ40 in down Syndrome

1995 • 372 citations

Physical, Morphological and Functional Differences between pH 5.8 and 7.4 Aggregates of the Alzheimer's Amyloid Peptide A β

1996 • 329 citations

Modulation of A beta adhesiveness and secretase site cleavage by zinc.

1994 • 327 citations

Arthritis and Allied Conditions

1990 • 319 citations

Conservation of the sequence of the Alzheimer's disease amyloid peptide in dog, polar bear and five other mammals by cross-species polymerase chain reaction analysis

1991 • 311 citations

Zinc-induced Alzheimer's Aβ1–40 Aggregation Is Mediated by Conformational Factors

1997 • 307 citations

An important role of heparan sulfate proteoglycan (perlecan) in a model system for the deposition and persistence of fibrillar aβ-amyloid in rat brain

1994 • 304 citations

Synovial fluid pH, lactate, oxygen and carbon dioxide partial pressure in various joint diseases

1971 • 291 citations

Surfactant properties of Alzheimer's A beta peptides and the mechanism of amyloid aggregation.

1994 • 261 citations

Enzyme Activities in Relation to pH and Lactate in Postmortem Brain in Alzheimer‐Type and Other Dementias

1990 • 252 citations

Isolation and characterization of amyloid P component from Alzheimer's disease and other types of cerebral amyloidosis.

1988 • 244 citations

Immunohistochemical characterization of alterations in the distribution of amyloid precursor proteins and beta-amyloid peptide after experimental brain injury in the rat

1996 • 242 citations

Glucose regulation and cognitive functions: relation to Alzheimer's disease and diabetes

1996 • 238 citations

Intrinsic stoichiometric equilibrium constants for the binding of zinc(II) and copper(II) to the high affinity site of serum albumin.

1993 • 214 citations

NMR studies of amyloid .beta.-peptides: proton assignments, secondary structure, and mechanism of an .alpha.-helix .fwdarw. .beta.-sheet conversion for a homologous, 28-residue, N-terminal fragment

1992 • 184 citations

Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.

1996 • 183 citations

Proteins of iron storage and transport

1986 • 173 citations

Protein chemical and immunocytochemical studies of meningovascular β-amyloid protein in Alzheimer's disease and normal aging

1988 • 173 citations

Amyloid β‐Protein Induces Its Own Production in Cultured Degenerating Cerebrovascular Smooth Muscle Cells

1995 • 162 citations

Structural Determinants of the Alzheimer's Amyloid β‐Peptide

1994 • 154 citations

Distribution of β‐amyloid protein in the brain following severe head injury

1995 • 145 citations

Insulin aggregation in artificial delivery systems

1980 • 143 citations

The Soluble Form of Alzheimer′s Amyloid β Protein Is Complexed to High Density Lipoprotein 3 and Very High Density Lipoprotein in Normal Human Plasma

1994 • 139 citations

The Effect of pH upon Human Transferrin: Selective Labelling of the Two Iron‐binding Sites

1976 • 137 citations

Decreased RNA Polymerase Activity in Mammalian Zinc Deficiency

1972 • 132 citations

Metals and Oxidative Damage in Neurological Disorders

1997 • 126 citations

Soluble Amyloid β-Protein Is a Marker of Alzheimer Amyloid in Brain But Not in Cerebrospinal Fluid

1994 • 126 citations

Brain tissue accumulates 67copper by two ligand-dependent saturable processes. A high affinity, low capacity and a low affinity, high capacity process.

1988 • 123 citations

Cerebrospinal fluid levels of amyloid β‐protein in alzheimer's disease: Inverse correlation with severity of dementia and effect of apolipoprotein e genotype

1995 • 116 citations

Aggregation and Metal‐Binding Properties of Mutant Forms of the Amyloid Aβ Peptide of Alzheimer's Disease

1996 • 116 citations

Characterization of the Binding of Amyloid‐β Peptide to Cell Culture‐Derived Native Apolipoprotein E2, E3, and E4 Isoforms and to Isoforms from Human Plasma

1997 • 113 citations

Amyloid β protein levels in cerebrospinal fluid are elevated in early‐onset Alzheimer's disease

1994 • 102 citations

Acidic pH enables caeruloplasmin to catalyse the modification of low‐density lipoprotein

1994 • 100 citations

THE DISTRIBUTION OF COPPER IN HUMAN BRAIN

1960 • 99 citations

Assessment of Amyloid β Protein in Cerebrospinal Fluid as an Aid in the Diagnosis of Alzheimer's Disease

1996 • 93 citations

Amyloidosis: a familiar problem in the light of current pathogenetic developments.

1983 • 82 citations

New advances in inclusion-body myositis

1993 • 80 citations

Polyclonals to β-amyloid(1–42) identify most plaque and vascular deposits in Alzheimer cortex, but not striatum

1994 • 79 citations

The Structure of Neuritic Plaques in the Cerebral Cortex of Aged Rats

1981 • 78 citations

Alzheimer amyloid-beta peptide forms denaturant-resistant complex with type epsilon 3 but not type epsilon 4 isoform of native apolipoprotein E.

1996 • 71 citations

Studies on Inflammation: X. The Cytological Picture of an Inflammatory Exudate in Relation to its Hydrogen Ion Concentration.

1934 • 55 citations

Native Complex Formation between Apolipoprotein E Isoforms and the Alzheimer's Disease Peptide Aβ

1996 • 54 citations

pH-Dependent Conformations of the Amyloid .beta.(1-28) Peptide Fragment Explored Using Molecular Dynamics

1995 • 53 citations

The effect of pH on the kinetics of iron release from human transferrin

1982 • 52 citations

Zinc Deficiency and Incorporation of 14C-labeled Methionine into Tissue Proteins in Rats

1969 • 52 citations

Ferrous iron release from transferrin by human neutrophil-derived superoxide anion: Effect of pH and iron saturation

1991 • 52 citations

Molecular pathogenesis of beta-amyloidosis in Alzheimer's disease and other cerebral amyloidoses.

1995 • 45 citations

Response : Zinc and Alzheimer's Disease

1995 • 45 citations

Alzheimer Amyloid-β Peptide Forms Denaturant-Resistant Complex with Type ε3 but Not Type ε4 Isoform of Native Apolipoprotein E

1996 • 45 citations

Development of a monoclonal antibody specific for the COOH-terminal of beta-amyloid 1-42 and its immunohistochemical reactivity in Alzheimer's disease and related disorders.

1994 • 44 citations

The binding of transition metal ions in insulin crystals

1968 • 39 citations

Effect of divalent metal ions and pH upon the binding reactivity of human serum amyloid P component, a C-reactive protein homologue, for zymosan. Preferential reactivity in the presence of copper and acidic pH.

1985 • 36 citations

Muscle fiber degeneration in distal myopathy with rimmed vacuole formation

1995 • 34 citations

Spectrophotometric determination of copper with N,N,N′,N′-tetraethylthiuram disulfide and an application of this method for studies on subcellular distribution of copper in rat brain

1970 • 31 citations

Myocardial zinc metabolism in experimental myocardial infarction.

1973 • 29 citations

Molecular Mechanisms of Dementia

1997 • 29 citations

Zinc sulfate and wound healing

1979 • 28 citations

Functional heterogeneity and pH-dependent dissociation properties of human transferrin

1976 • 28 citations

Selective binding of soluble Abeta1-40 and Abeta1-42 to a subset of senile plaques.

1996 • 27 citations

Chemical modification of glucosamine-6-phosphate synthase by diethyl pyrocarbonate: Evidence of histidine requirement for enzymatic activity

1992 • 23 citations

Inflammation-associated amyloidogenesis

1994 • 22 citations

Uptake of 67Cu by Ceruloplasmin In Vitro

1975 • 19 citations

THE BIOLOGIC SIGNIFICANCE OF AMYLOID*

1982 • 16 citations

Two‐dimensional NMR assignment of hyperfine‐shifted resonances of very fast relaxing metal binding sites of proteins by NOE spectroscopy

1993 • 13 citations

Immunohistochemical localization of amyloid beta-protein deposits in extracerebral tissues of patients with Alzheimer's disease.

1993 • 6 citations

Inflammatory diseases and copper

1985 • 4 citations

The titration curve of insulin in the presence of various bivalent metal ions

1968 • 4 citations