The Tumor Necrosis Factor Family Receptors RANK and CD40 Cooperatively Establish the Thymic Medullary Microenvironment and Self-Tolerance

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

The two NF-κB activation pathways and their role in innate and adaptive immunity

2004 • 2,476 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 • 869 citations

Circuitry of nuclear factor κB signaling

2006 • 861 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution

2002 • 802 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

A CENTRAL ROLE FOR CENTRAL TOLERANCE

2006 • 730 citations

CD40/CD154 Interactions at the Interface of Tolerance and Immunity

2004 • 673 citations

Histone H3 phosphorylation by IKK-α is critical for cytokine-induced gene expression

2003 • 568 citations

A nucleosomal function for IκB kinase-α in NF-κB-dependent gene expression

2003 • 512 citations

Identification of TRAF6, a Novel Tumor Necrosis Factor Receptor-associated Factor Protein That Mediates Signaling from an Amino-terminal Domain of the CD40 Cytoplasmic Region

1996 • 484 citations

RANK signals from CD4+3− inducer cells regulate development of Aire-expressing epithelial cells in the thymic medulla

2007 • 463 citations

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis

2001 • 450 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells

2006 • 443 citations

Nuclear cytokine-activated IKKα controls prostate cancer metastasis by repressing Maspin

2007 • 421 citations

The Cytokine RANKL Produced by Positively Selected Thymocytes Fosters Medullary Thymic Epithelial Cells that Express Autoimmune Regulator

2008 • 405 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

The IκB Function of NF-κB2 p100 Controls Stimulated Osteoclastogenesis

2003 • 278 citations

A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts

2003 • 276 citations

Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma

2005 • 272 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

Different Cytokines Induce Surface Lymphotoxin-αβ on IL-7 Receptor-α Cells that Differentially Engender Lymph Nodes and Peyer's Patches

2002 • 240 citations

Receptor-Specific Signaling for Both the Alternative and the Canonical NF-κB Activation Pathways by NF-κB-Inducing Kinase

2004 • 231 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin

2007 • 207 citations

Back to Central Tolerance

2004 • 202 citations

Transcription of the RelB gene is regulated by NF-κB

2001 • 200 citations

Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I

2001 • 200 citations

Biology of the TRANCE axis

2003 • 197 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

2000 • 185 citations

Generating intrathymic microenvironments to establish T-cell tolerance

2007 • 184 citations

The role of TRAF6 in signal transduction and the immune response

2004 • 134 citations

NF-κB2 is required for the establishment of central tolerance through an Aire-dependent pathway

2006 • 128 citations

Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation

2002 • 111 citations

The Lymphotoxin Pathway Regulates Aire-Independent Expression of Ectopic Genes and Chemokines in Thymic Stromal Cells

2008 • 107 citations

Characteristics and Biological Functions of TRAF6

2007 • 101 citations

Lymphotoxin Pathway and Aire Influences on Thymic Medullary Epithelial Cells Are Unconnected

2007 • 95 citations

Essential Role of IκB Kinase α in Thymic Organogenesis Required for the Establishment of Self-Tolerance

2006 • 86 citations

Thymus dysfunction and chronic inflammatory disease in gp39 transgenic mice

1997 • 86 citations

A Role for the IκB Family Member Bcl-3 in the Control of Central Immunologic Tolerance

2007 • 69 citations

Thymic Overexpression of CD40 Ligand Disrupts Normal Thymic Epithelial Organization

1997 • 56 citations

Cloning of the APECED gene provides new insight into human autoimmunity

1999 • 52 citations

NIK Is Involved in Nucleosomal Regulation by Enhancing Histone H3 Phosphorylation by IKKα

2006 • 50 citations

Developmental Stage-Dependent Collaboration between the TNF Receptor-Associated Factor 6 and Lymphotoxin Pathways for B Cell Follicle Organization in Secondary Lymphoid Organs

2007 • 22 citations