The IκB Function of NF-κB2 p100 Controls Stimulated Osteoclastogenesis

NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

1998 • 5,178 citations

Bone Resorption by Osteoclasts

2000 • 3,797 citations

The ubiquitinproteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB

1994 • 2,124 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling Pathway

2001 • 1,333 citations

TNF-α induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand

2000 • 1,330 citations

MAP3K-related kinase involved in NF-KB induction by TNF, CD95 and IL-1

1997 • 1,294 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

Osteopetrosis in mice lacking NF-κB1 and NF-κB2

1997 • 988 citations

NF-κB-Inducing Kinase Regulates the Processing of NF-κB2 p100

2001 • 807 citations

Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts

2000 • 715 citations

BAFF-induced NEMO-independent processing of NF-κB2 in maturing B cells

2002 • 674 citations

Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-α

2000 • 666 citations

Role of cytokines and inflammatory mediators in tissue destruction

1993 • 611 citations

Identification and Characterization of the New Osteoclast Progenitor with Macrophage Phenotypes Being Able to Differentiate into Mature Osteoclasts

2000 • 597 citations

Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2

1997 • 552 citations

The NF-κB Activation Pathway: A Paradigm in Information Transfer from Membrane to Nucleus

1999 • 485 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

CD40 regulates the processing of NF-kappaB2 p100 to p52

2002 • 435 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

Identification and Characterization of a Constitutively Active STAT5 Mutant That Promotes Cell Proliferation

1998 • 426 citations

Osteoclast Differentiation Factor Acts as a Multifunctional Regulator in Murine Osteoclast Differentiation and Function

1999 • 412 citations

The precursor of NF-κB p50 has IκB-like functions

1992 • 409 citations

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

2001 • 407 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Interleukin-1 receptor antagonist and tumor necrosis factor binding protein decrease osteoclast formation and bone resorption in ovariectomized mice.

1994 • 341 citations

Theoretical perspective: A new model for the regulation of bone resorption, with particular reference to the effects of bisphosphonates

1996 • 331 citations

A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

1994 • 327 citations

Lipopolysaccharide-stimulated osteoclastogenesis is mediated by tumor necrosis factor via its P55 receptor.

1997 • 277 citations

Interleukin-4 Reversibly Inhibits Osteoclastogenesis via Inhibition of NF-κB and Mitogen-activated Protein Kinase Signaling

2002 • 202 citations

Essential Role of Nuclear Factor (NF)-κB–Inducing Kinase and Inhibitor of κb (Iκb) Kinase α in Nf-κb Activation through Lymphotoxin β Receptor, but Not through Tumor Necrosis Factor Receptor I

2001 • 200 citations

A role for TGFβ1 in osteoclast differentiation and survival

2000 • 195 citations

Gastric Hyperplasia and Increased Proliferative Responses of Lymphocytes in Mice Lacking the COOH-terminal Ankyrin Domain of NF-κB2

1997 • 178 citations

Abnormal Immune Function of Hemopoietic Cells from Alymphoplasia (aly) Mice, a Natural Strain with Mutant NF-κB-Inducing Kinase

2000 • 164 citations

Dimerization of NF-KB2 with RelA(p65) regulates DNA binding, transcriptional activation, and inhibition by an I kappa B-alpha (MAD-3).

1993 • 135 citations

Lymphotoxin and lipopolysaccharide induce NF‐κB‐p52 generation by a co‐translational mechanism

2003 • 127 citations

Endogenous Production of TGF-β Is Essential for Osteoclastogenesis Induced by a Combination of Receptor Activator of NF-κB Ligand and Macrophage-Colony- Stimulating Factor

2000 • 124 citations

The generation of nfkb2 p52: mechanism and efficiency

1999 • 114 citations

Transcriptional Regulation of NF-κB2: Evidence for κB-Mediated Positive and Negative Autoregulation

1994 • 112 citations

NF-κB p100 (Lyt-10) is a Component of H2TF1 and can Function as an IκB-Like Molecule

1993 • 106 citations

Both N- and C-Terminal Domains of RelB Are Required for Full Transactivation: Role of the N-Terminal Leucine Zipper-Like Motif

1993 • 87 citations

Lineage-Restricted Function of Nuclear Factor κB–Inducing Kinase (Nik) in Transducing Signals via Cd40

2000 • 69 citations

Dimerization of NF-KB2 with RelA(p65) Regulates DNA Binding, Transcriptional Activation, and Inhibition by an IκB-α (MAD-3)

1993 • 43 citations

Genomic organization and chromosomal mapping of mouse nuclear factor kappa B 2 ( NFKB2 )

1999 • 9 citations