RANK-L and RANK: T Cells, Bone Loss, and Mammalian Evolution

Dendritic cells and the control of immunity

1998 • 14,345 citations

Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation

1998 • 5,369 citations

Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density

1997 • 5,058 citations

An endotoxin-induced serum factor that causes necrosis of tumors.

1975 • 4,522 citations

Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL

1998 • 4,184 citations

The TNF and TNF Receptor Superfamilies

2001 • 3,533 citations

OPGL is a key regulator of osteoclastogenesis, lymphocyte development and lymph-node organogenesis

1999 • 3,340 citations

ROLE OF CYTOKINES IN RHEUMATOID ARTHRITIS

1996 • 2,527 citations

osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification

1998 • 2,473 citations

A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function

1997 • 2,257 citations

Activated T cells regulate bone loss and joint destruction in adjuvant arthritis through osteoprotegerin ligand

1999 • 1,832 citations

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

1991 • 1,630 citations

Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand

1999 • 1,621 citations

CD40 AND CD154 IN CELL-MEDIATED IMMUNITY

1998 • 1,546 citations

Proapoptotic Bcl-2 Relative Bim Required for Certain Apoptotic Responses, Leukocyte Homeostasis, and to Preclude Autoimmunity

1999 • 1,500 citations

RANK is essential for osteoclast and lymph node development

1999 • 1,417 citations

Consequences of Cell Death

2000 • 1,382 citations

T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-γ

2000 • 1,302 citations

Tumor Necrosis Factor α Stimulates Osteoclast Differentiation by a Mechanism Independent of the Odf/Rankl–Rank Interaction

2000 • 1,268 citations

TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling

1999 • 1,267 citations

Identity of Osteoclastogenesis Inhibitory Factor (OCIF) and Osteoprotegerin (OPG): A Mechanism by which OPG/OCIF Inhibits Osteoclastogenesisin Vitro¹

1998 • 1,211 citations

Osteoprotegerin Is a Receptor for the Cytotoxic Ligand TRAIL

1998 • 1,177 citations

RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism

2000 • 1,119 citations

The immune responses in CD40-deficient mice: Impaired immunoglobulin class switching and germinal center formation

1994 • 1,099 citations

TRANCE Is a Novel Ligand of the Tumor Necrosis Factor Receptor Family That Activates c-Jun N-terminal Kinase in T Cells

1997 • 1,054 citations

Requirement for NF-κB in osteoclast and B-cell development

1997 • 994 citations

Osteopetrosis in mice lacking NF-κB1 and NF-κB2

1997 • 988 citations

Initiation of liver growth by tumor necrosis factor: Deficient liver regeneration in mice lacking type I tumor necrosis factor receptor

1997 • 937 citations

Reduction of atherosclerosis in mice by inhibition of CD40 signalling

1998 • 917 citations

Organ-Specific Disease Provoked by Systemic Autoimmunity

1996 • 880 citations

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

1997 • 869 citations

A Gender Gap in Autoimmunity

1999 • 856 citations

Development of peripheral lymphoid organs and natural killer cells depends on the helix–loop–helix inhibitor Id2

1999 • 841 citations

TRANCE/RANKL Knockout Mice Are Protected from Bone Erosion in a Serum Transfer Model of Arthritis

2001 • 803 citations

Mice deficient for the CD40 ligand

1994 • 753 citations

Maternal-Fetal Calcium and Bone Metabolism During Pregnancy, Puerperium, and Lactation*

1997 • 731 citations

The Osteoclast Differentiation Factor Osteoprotegerin-Ligand Is Essential for Mammary Gland Development

2000 • 731 citations

RANK Is the Essential Signaling Receptor for Osteoclast Differentiation Factor in Osteoclastogenesis

1998 • 729 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

Tumor Necrosis Factor-α Induces Differentiation of and Bone Resorption by Osteoclasts

2000 • 700 citations

The Ligand for Osteoprotegerin (OPGL) Directly Activates Mature Osteoclasts

1999 • 697 citations

Estrogen Stimulates Gene Expression and Protein Production of Osteoprotegerin in Human Osteoblastic Cells*

1999 • 657 citations

Developing Lymph Nodes Collect CD4 + CD3 − LTβ + Cells That Can Differentiate to APC, NK Cells, and Follicular Cells but Not T or B Cells

1997 • 654 citations

Severe osteopetrosis, defective interleukin‐1 signalling and lymph node organogenesis in TRAF6‐deficient mice

1999 • 639 citations

DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES

1999 • 636 citations

Interleukin-1β and tumor necrosis factor-α, but not interleukin-6, stimulate osteoprotegerin ligand gene expression in human osteoblastic cells

1999 • 633 citations

Inherited Human Caspase 10 Mutations Underlie Defective Lymphocyte and Dendritic Cell Apoptosis in Autoimmune Lymphoproliferative Syndrome Type II

1999 • 631 citations

Distinct Roles in Lymphoid Organogenesis for Lymphotoxins α and β Revealed in Lymphotoxin β–Deficient Mice

1997 • 590 citations

TRANCE, a TNF Family Member, Activates Akt/PKB through a Signaling Complex Involving TRAF6 and c-Src

1999 • 583 citations

Cell biology of the osteoclast

1999 • 560 citations

In Vivo Detection of Dendritic Cell Antigen Presentation to CD4+ T Cells

1997 • 560 citations

Osteoprotegerin Reverses Osteoporosis by Inhibiting Endosteal Osteoclasts and Prevents Vascular Calcification by Blocking a Process Resembling Osteoclastogenesis

2000 • 559 citations

Involvement of p38 Mitogen-activated Protein Kinase Signaling Pathway in Osteoclastogenesis Mediated by Receptor Activator of NF-κB Ligand (RANKL)

2000 • 511 citations

Functional human T-cell immunity and osteoprotegerin ligand control alveolar bone destruction in periodontal infection

2000 • 497 citations

Osteoprotegerin blocks bone cancer-induced skeletal destruction, skeletal pain and pain-related neurochemical reorganization of the spinal cord

2000 • 496 citations

Successful treatment of active ankylosing spondylitis with the anti–tumor necrosis factor α monoclonal antibody infliximab

2000 • 492 citations

Protein Expression and Functional Difference of Membrane-Bound and Soluble Receptor Activator of NF-κB Ligand: Modulation of the Expression by Osteotropic Factors and Cytokines

2000 • 491 citations

Tumor Necrosis Factor-α (TNF) Stimulates RANKL-induced Osteoclastogenesis via Coupling of TNF Type 1 Receptor and RANK Signaling Pathways

2001 • 476 citations

Mutations in TNFRSF11A, affecting the signal peptide of RANK, cause familial expansile osteolysis

2000 • 473 citations

The TRAF Family of Signal Transducers Mediates NF-κB Activation by the TRANCE Receptor

1998 • 458 citations

Osteoprotegerin inhibits prostate cancer–induced osteoclastogenesis and prevents prostate tumor growth in the bone

2001 • 453 citations

Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis

2001 • 450 citations

Calcium homeostasis and bone metabolism during pregnancy, lactation, and postweaning: a longitudinal study

1995 • 433 citations

Evidence for a Role of a Tumor Necrosis Factor-α (TNF-α)-converting Enzyme-like Protease in Shedding of TRANCE, a TNF Family Member Involved in Osteoclastogenesis and Dendritic Cell Survival

1999 • 414 citations

Characterization of the Intracellular Domain of Receptor Activator of NF-κB (RANK)

1998 • 408 citations

Role of Lymphotoxin and the Type I TNF Receptor in the Formation of Germinal Centers

1996 • 386 citations

The regulation of the expression of gp39, the CD40 ligand, on normal and cloned CD4+ T cells.

1993 • 384 citations

Abnormal development of secondary lymphoid tissues in lymphotoxin β-deficient mice

1997 • 365 citations

STRUCTURE AND FUNCTION OF THE PRE-T CELL RECEPTOR

1997 • 362 citations

Trance, a Tumor Necrosis Factor Family Member, Enhances the Longevity and Adjuvant Properties of Dendritic Cells in Vivo

2000 • 335 citations

Prolactin Controls Mammary Gland Development via Direct and Indirect Mechanisms

1999 • 333 citations

The Involvement of Multiple Tumor Necrosis Factor Receptor (TNFR)-associated Factors in the Signaling Mechanisms of Receptor Activator of NF-κB, a Member of the TNFR Superfamily

1998 • 330 citations

TRANCE, a TNF Family Member, Is Differentially Expressed on T Cell Subsets and Induces Cytokine Production in Dendritic Cells

1999 • 323 citations

TNF-Related Apoptosis-Inducing Ligand (TRAIL) Induces Apoptosis in Fas Ligand-Resistant Melanoma Cells and Mediates CD4 T Cell Killing of Target Cells

1998 • 316 citations

The genetic transformation of bone biology

1999 • 313 citations

OPG/FDCR-1, a TNF Receptor Family Member, Is Expressed in Lymphoid Cells and Is Up-Regulated by Ligating CD40

1998 • 304 citations

Activated Human T Cells Release Bioactive Fas Ligand and APO2 Ligand in Microvesicles

1999 • 302 citations

Diverse roles of the tumor necrosis factor family member TRANCE in skeletal physiology revealed by TRANCE deficiency and partial rescue by a lymphocyte-expressed TRANCE transgene

2000 • 297 citations

Lymph Node Genesis Is Induced by Signaling through the Lymphotoxin β Receptor

1998 • 294 citations

Enforced Expression of Bcl-2 in Monocytes Rescues Macrophages and Partially Reverses Osteopetrosis in op/op Mice

1997 • 292 citations

Osteoprotegerin inhibits osteolysis and decreases skeletal tumor burden in syngeneic and nude mouse models of experimental bone metastasis.

2001 • 291 citations

Animal Models of Arthritis: Relevance to Human Disease

1999 • 288 citations

Maternal-Fetal Calcium and Bone Metabolism During Pregnancy, Puerperium, and Lactation

1997 • 286 citations

Regulation of Peripheral Lymph Node Genesis by the Tumor Necrosis Factor Family Member Trance

2000 • 262 citations

TRANCE, a Tumor Necrosis Factor Family Member Critical for CD40 Ligand–independent T Helper Cell Activation

1999 • 262 citations

IL-12 Alone and in Synergy with IL-18 Inhibits Osteoclast Formation In Vitro

2001 • 251 citations

Epidemiology of Osteoporosis

2001 • 240 citations

Involvement of TNF-Related Apoptosis-Inducing Ligand in Human CD4+ T Cell-Mediated Cytotoxicity

1999 • 230 citations

Peyer’s patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor

1997 • 205 citations

17β-Estradiol Stimulates Expression of Osteoprotegerin by a Mouse Stromal Cell Line, ST-2, via Estrogen Receptor-α*

2001 • 193 citations

Osteoprotegerin, a Crucial Regulator of Bone Metabolism, Also Regulates B Cell Development and Function

2001 • 187 citations

A Chimeric Form of Osteoprotegerin Inhibits Hypercalcemia and Bone Resorption Induced by IL-1β, TNF-α, PTH, PTHrP, and 1,25(OH)2D3

1999 • 186 citations

IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-κB

2001 • 184 citations

Regulation of mammary gland development by tissue interaction.

1999 • 183 citations

Osteoprotegerin mRNA is expressed in primary human osteoblast-like cells: down-regulation by glucocorticoids

1998 • 183 citations

Gender and risk of autoimmune diseases: possible role of estrogenic compounds.

1999 • 183 citations

Colony stimulating factor 1 is required for mammary gland development during pregnancy.

1994 • 177 citations

Prostaglandin E2 Induces Expression of Receptor Activator of Nuclear Factor–κB Ligand/Osteoprotegrin Ligand on Pre-B Cells: Implications for Accelerated Osteoclastogenesis in Estrogen Deficiency

2000 • 170 citations

IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor γ1

2001 • 158 citations

Bone Mineral Density in Acute Stroke Patients

2001 • 142 citations

The effects of pregnancy on autoimmune diseases

1998 • 140 citations

Bone Mineral Density and Bone Metabolism in Diabetes Mellitus

1997 • 134 citations

Regulation of Osteoprotegerin mRNA Levels by Prostaglandin E2in Human Bone Marrow Stroma Cells

1998 • 132 citations

A Positive Regulatory Role for Cbl Family Proteins in Tumor Necrosis Factor-related Activation-induced Cytokine (TRANCE) and CD40L-mediated Akt Activation

2001 • 123 citations

Inhibition of cartilage and bone destruction in adjuvant arthritis in the rat by a matrix metalloproteinase inhibitor.

1995 • 109 citations

Lymphocyte in vitro Cytotoxicity: Specific Release of Lymphotoxin-like Materials from Tuberculin-sensitive Lymphoid Cells

1969 • 105 citations

Selective disruption of lymphotoxin ligands reveals a novel set of mucosal lymph nodes and unique effects on lymph node cellular organization

1997 • 104 citations

Osteoprotegerin inhibits osteoclast formation and bone resorbing activity in giant cell tumors of bone

2001 • 103 citations

Tumor Necrosis Factor-α and -β Upregulate the Levels of Osteoprotegerin mRNA in Human Osteosarcoma MG-63 Cells

1998 • 102 citations

Gender differences in autoimmunity: molecular basis for estrogen effects in systemic lupus erythematosus

2001 • 100 citations

Bone Mineral Density and Bone Turnover in Asthmatics Treated with Long-Term Inhaled or Oral Glucocorticoids

1998 • 96 citations

Bone loss in autoimmune chronic active hepatitis on maintenance corticosteroid therapy

1985 • 93 citations

Side-branching in the mammary gland: the progesterone–Wnt connection

2000 • 89 citations

FADD/MORT1, a signal transducer that can promote cell death or cell growth

1999 • 84 citations

Impaired Mammary Gland Development in Cyl-1−/− Mice during Pregnancy and Lactation Is Epithelial Cell Autonomous

1999 • 82 citations

Cartilage destruction and bone erosion in arthritis: the role of tumour necrosis factor alpha

2000 • 64 citations

Activation of c-Jun N-Terminal Kinase and Activator Protein 1 by Receptor Activator of Nuclear Factor κB

2000 • 63 citations

Enhanced prostanoid release from monocytes of patients with rheumatoid arthritis and active systemic lupus erythematosus.

1985 • 53 citations

Arterial calcification in face of osteoporosis in ageing: can we blame oxidized lipids?

1997 • 52 citations

A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?

2000 • 51 citations

Structure of the mouse osteoclastogenesis inhibitory factor (OCIF) gene and its expression in embryogenesis

1998 • 45 citations

Nutritional Deficiencies in the Neonate

1986 • 33 citations

How can we improve the treatment of bone metastases further?

1998 • 32 citations

Suicide by order: Some open questions about the cell-killing activities of the TNF ligand and receptor families

1996 • 30 citations

Vertebral compression fractures at the onset of acute lymphoblastic leukemia in a child.

1991 • 27 citations

Reduced incidence of alcohol related deaths in subjects with rheumatoid arthritis

2000 • 16 citations

New treatments for rheumatoid arthritis

1999 • 13 citations

One-year inhibition of tumor necrosis factor-α: a major success or a larger puzzle?

2001 • 9 citations

TRANCE/RANKL knockout mice are protected from bone erosion in the K/BxN serum transfer model of arthritis

2001 • 5 citations