Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin

Multifunctional strands in tight junctions

2001 • 2,392 citations

Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Claudin-based tight junctions are crucial for the mammalian epidermal barrier

2002 • 1,412 citations

Positional cloning of the APECED gene

1997 • 1,385 citations

An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains

1997 • 1,155 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

A Single Gene Product, Claudin-1 or -2, Reconstitutes Tight Junction Strands and Recruits Occludin in Fibroblasts

1998 • 923 citations

Multiorgan inflammation and hematopoietic abnormalities in mice with a targeted disruption of RelB, a member of the NF-κB/Rel family

1995 • 810 citations

Expression of relB is required for the development of thymic medulla and dendritic cells

1995 • 794 citations

A CENTRAL ROLE FOR CENTRAL TOLERANCE

2006 • 730 citations

Journey through the thymus: stromal guides for T-cell development and selection

2006 • 690 citations

Clostridium perfringens Enterotoxin Fragment Removes Specific Claudins from Tight Junction Strands

1999 • 609 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Central Tolerance to Tissue-specific Antigens Mediated by Direct and Indirect Antigen Presentation

2004 • 474 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Formation of a functional thymus initiated by a postnatal epithelial progenitor cell

2006 • 381 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

Claudin-based barrier in simple and stratified cellular sheets

2002 • 355 citations

Multi-PDZ Domain Protein 1 (MUPP1) Is Concentrated at Tight Junctions through Its Possible Interaction with Claudin-1 and Junctional Adhesion Molecule

2002 • 350 citations

Self-representation in the thymus: an extended view

2004 • 339 citations

Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium

2006 • 331 citations

Developmental control point in induction of thymic cortex regulated by a subpopulation of prothymocytes

1995 • 295 citations

Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Generation of a complete thymic microenvironment by MTS24+ thymic epithelial cells

2002 • 290 citations

Development of Autoimmunity against Transcriptionally Unrepressed Target Antigen in the Thymus of Aire-Deficient Mice

2005 • 287 citations

Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma

2005 • 272 citations

Molecular Cloning and Functional Characterization of the Receptor for Clostridium perfringens Enterotoxin

1997 • 272 citations

TRAF6 Is a Critical Factor for Dendritic Cell Maturation and Development

2003 • 269 citations

Differential expression of PD-L1 and PD-L2, ligands for an inhibitory receptor PD-1, in the cells of lymphohematopoietic tissues

2002 • 269 citations

Identification and Characterization of Thymic Epithelial Progenitor Cells

2002 • 269 citations

Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

Developing a new paradigm for thymus organogenesis

2004 • 242 citations

Stepwise development of thymic microenvironments in vivo is regulated by thymocyte subsets

2000 • 219 citations

Thymus medulla consisting of epithelial islets each derived from a single progenitor

2001 • 211 citations

Functional evidence for a single endodermal origin for the thymic epithelium

2004 • 209 citations

NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

2004 • 207 citations

Analysis of thymic stromal cell populations using flow cytometry

2002 • 206 citations

Thymic epithelial cells provide unique signals for positive selection of CD4+CD8+ thymocytes in vitro.

1994 • 197 citations

Lymphotoxin pathway directs thymic Aire expression

2003 • 193 citations

Cell migration and the control of post-natal T-cell lymphopoiesis in the thymus

2003 • 186 citations

Thymic generation and regeneration

2003 • 144 citations

Thymic microenvironments, 3-D versus 2-D?

1999 • 139 citations

Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage

2001 • 135 citations

Alteration of intra-pancreatic target-organ specificity by abrogation of Aire in NOD mice

2006 • 117 citations

Organization of thymic medullary epithelial heterogeneity: implications for mechanisms of epithelial differentiation

2002 • 111 citations

Features of Medullary Thymic Epithelium Implicate Postnatal Development in Maintaining Epithelial Heterogeneity and Tissue-Restricted Antigen Expression

2006 • 79 citations

Contrasting models of promiscuous gene expression by thymic epithelium

2005 • 67 citations

T Cell Tolerance to a Neo-Self Antigen Expressed by Thymic Epithelial Cells: The Soluble Form Is More Effective Than the Membrane-Bound Form

2003 • 52 citations