NF-κB2 is required for the establishment of central tolerance through an Aire-dependent pathway

Control of Regulatory T Cell Development by the Transcription Factor Foxp3

2003 • 7,902 citations

Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

2017 • 4,003 citations

Tolerogenic Dendritic Cells

2003 • 3,131 citations

An essential role for Scurfin in CD4+CD25+ T regulatory cells

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Projection of an Immunological Self Shadow Within the Thymus by the Aire Protein

2002 • 2,371 citations

Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-κB

1995 • 1,849 citations

Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide

2001 • 1,659 citations

Targeted disruption of the p50 subunit of NF-κB leads to multifocal defects in immune responses

1995 • 1,184 citations

Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self

2001 • 1,043 citations

The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB Pathways

2002 • 891 citations

Aire regulates negative selection of organ-specific T cells

2003 • 789 citations

The Lymphotoxin β Receptor Controls Organogenesis and Affinity Maturation in Peripheral Lymphoid Tissues

1998 • 710 citations

DEVELOPMENT AND MATURATION OF SECONDARY LYMPHOID TISSUES

1999 • 636 citations

The Cellular Mechanism of Aire Control of T Cell Tolerance

2005 • 622 citations

Promiscuous gene expression in thymic epithelial cells is regulated at multiple levels

2005 • 540 citations

Aire deficient mice develop multiple features of APECED phenotype and show altered immune response

2002 • 463 citations

Alymphoplasia is caused by a point mutation in the mouse gene encoding Nf-κb-inducing kinase

1999 • 448 citations

Mice Deficient in Nuclear Factor (NF)-κB/p52 Present with Defects in Humoral Responses, Germinal Center Reactions, and Splenic Microarchitecture

1998 • 433 citations

Defective Lymphotoxin-β Receptor-Induced NF-κB Transcriptional Activity in NIK-Deficient Mice

2001 • 407 citations

Nuclear Factor (NF)-κB2 (p100/p52) Is Required for Normal Splenic Microarchitecture and B Cell–mediated Immune Responses

1998 • 396 citations

Thymic Medullary Epithelial Cell Differentiation, Thymocyte Emigration, and the Control of Autoimmunity Require Lympho–Epithelial Cross Talk via LTβR

2003 • 361 citations

Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters

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Dendritic Cell Apoptosis in the Maintenance of Immune Tolerance

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A new mutation, aly, that induces a generalized lack of lymph nodes accompanied by immunodeficiency in mice

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NF-κB RelA-deficient Lymphocytes: Normal Development of T Cells and B Cells, Impaired Production of IgA and IgG1 and Reduced Proliferative Responses

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Interdependence of cortical thymic epithelial cell differentiation and T-lineage commitment

1998 • 292 citations

Gene Dosage–limiting Role ofAirein Thymic Expression, Clonal Deletion, and Organ-specific Autoimmunity

2004 • 291 citations

Dependence of Self-Tolerance on TRAF6-Directed Development of Thymic Stroma

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Normal Thymic Architecture and Negative Selection Are Associated with Aire Expression, the Gene Defective in the Autoimmune-Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED)

2000 • 261 citations

Dendritic Cells in Immunity and Tolerance—Do They Display Opposite Functions?

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Mature T Cells Depend on Signaling through the IKK Complex

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NF-κB-Inducing Kinase Establishes Self-Tolerance in a Thymic Stroma-Dependent Manner

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Regulation of secondary lymphoid organ development by the nuclear factor‐κB signal transduction pathway

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Lymphotoxin pathway directs thymic Aire expression

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RNA and protein expression of the murine autoimmune regulator gene (Aire) in normal, RelB-deficient and in NOD mouse

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Epithelial heterogeneity in the murine thymus: fucose-specific lectins bind medullary epithelial cells.

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Coordination between NF-κB family members p50 and p52 is essential for mediating LTβR signals in the development and organization of secondary lymphoid tissues

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Epithelial heterogeneity in the murine thymus: a cell surface glycoprotein expressed by subcapsular and medullary epithelium.

1991 • 93 citations

Identification of a Role for NF-κB2 in the Regulation of Apoptosis and in Maintenance of T Cell-Mediated Immunity toToxoplasma gondii

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Increased antigen presenting cell‐mediated T cell activation in mice and patients without the autoimmune regulator

2006 • 81 citations

Pancreatic Hormone Expression in the Murine Thymus: Localization in Dendritic Cells and Macrophages

1998 • 78 citations

CD4+ CD25+ Regulatory T Cell Repertoire Formation in Response to Varying Expression of a neo-Self-Antigen

2004 • 76 citations

Cutting Edge: NF-κB2 Is a Negative Regulator of Dendritic Cell Function

2004 • 50 citations

Dendritic Cells in Human Thymus and Periphery Display a Proinsulin Epitope in a Transcription-Dependent, Capture-Independent Fashion

2005 • 44 citations

Expression of tissue‐specific autoantigens in the hematopoietic cells leads to activation‐induced cell death of autoreactive T cells in the secondary lymphoid organs

2004 • 29 citations