A Selective IKK-2 Inhibitor Blocks NF-κB-dependent Gene Expression in Interleukin-1β-stimulated Synovial Fibroblasts

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Missing Pieces in the NF-κB Puzzle

2002 • 3,560 citations

NF-κB at the crossroads of life and death

2002 • 2,684 citations

A cytokine-responsive IκB kinase that activates the transcription factor NF-κB

1997 • 2,137 citations

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

1997 • 2,048 citations

The IκB Kinase Complex (IKK) Contains Two Kinase Subunits, IKKα and IKKβ, Necessary for IκB Phosphorylation and NF-κB Activation

1997 • 1,802 citations

The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β

1998 • 1,561 citations

Control of IκB-α Proteolysis by Site-Specific, Signal-Induced Phosphorylation

1995 • 1,443 citations

Signal-induced site-specific phosphorylation targets I kappa B alpha to the ubiquitin-proteasome pathway.

1995 • 1,296 citations

Duration of Nuclear NF-κB Action Regulated by Reversible Acetylation

2001 • 1,193 citations

Complementation Cloning of NEMO, a Component of the IκB Kinase Complex Essential for NF-κB Activation

1998 • 1,070 citations

Novel Inhibitors of Cytokine-induced IκBα Phosphorylation and Endothelial Cell Adhesion Molecule Expression Show Anti-inflammatory Effects in Vivo

1997 • 1,045 citations

Severe Liver Degeneration in Mice Lacking the IκB Kinase 2 Gene

1999 • 978 citations

IKK-γ is an essential regulatory subunit of the IκB kinase complex

1998 • 950 citations

The Phosphorylation Status of Nuclear NF-ΚB Determines Its Association with CBP/p300 or HDAC-1

2002 • 934 citations

The IKKβ Subunit of IκB Kinase (IKK) is Essential for Nuclear Factor κB Activation and Prevention of Apoptosis

1999 • 922 citations

NF-κB as a Therapeutic Target in Multiple Myeloma

2002 • 906 citations

Positive and Negative Regulation of IκB Kinase Activity Through IKKβ Subunit Phosphorylation

1999 • 855 citations

IκB Kinases Phosphorylate NF-κB p65 Subunit on Serine 536 in the Transactivation Domain

1999 • 812 citations

Mapping of the Inducible IκB Phosphorylation Sites That Signal Its Ubiquitination and Degradation†

1996 • 717 citations

Mutual regulation of the transcriptional activator NF-kappa B and its inhibitor, I kappa B-alpha.

1993 • 639 citations

Signal-induced degradation of I kappa B alpha requires site-specific ubiquitination.

1995 • 558 citations

BMS-345541 Is a Highly Selective Inhibitor of IκB Kinase That Binds at an Allosteric Site of the Enzyme and Blocks NF-κB-dependent Transcription in Mice

2003 • 505 citations

Tumor Necrosis Factor α-induced Phosphorylation of RelA/p65 on Ser529 Is Controlled by Casein Kinase II

2000 • 445 citations

Inducible Nuclear Expression of Newly Synthesized IκBα Negatively Regulates DNA-Binding and Transcriptional Activities of NF-κB

1995 • 442 citations

Transcriptional Activation by NF-κB Requires Multiple Coactivators

1999 • 433 citations

Signal-induced ubiquitination of Ikappa Balpha by the F-box protein Slimb/beta -TrCP

1999 • 424 citations

NF-κB as a primary regulator of the stress response

1999 • 407 citations

Nuclear localization of IκBα promotes active transport of NF-κB from the nucleus to the cytoplasm

1997 • 405 citations

Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

2001 • 375 citations

A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes

2000 • 368 citations

Deficiency of T2K leads to apoptotic liver degeneration and impaired NF-kappaB-dependent gene transcription

2000 • 365 citations

NAK is an IκB kinase-activating kinase

2000 • 365 citations

Activation of NF-kappa B in vivo is regulated by multiple phosphorylations.

1994 • 362 citations

Phosphorylation of IκBα Precedes but Is Not Sufficient for Its Dissociation from NF-κB

1995 • 351 citations

Regulation of the transcriptional activity of the nuclear factor-κB p65 subunit

2002 • 305 citations

The IKK/NF-kappa B pathway.

2002 • 271 citations

An N-terminal nuclear export signal is required for the nucleocytoplasmic shuttling of Ikappa Balpha

1999 • 264 citations

IκB-independent control of NF-κB activity by modulatory phosphorylations

2001 • 241 citations

The IKK/NF-κB pathway

2002 • 239 citations

Nuclear Retention of IκBα Protects It from Signal-induced Degradation and Inhibits Nuclear Factor κB Transcriptional Activation

1999 • 232 citations

Activation of Nuclear Transcription Factor NF-κB by Interleukin-1 Is Accompanied by Casein Kinase II-mediated Phosphorylation of the p65 Subunit

1997 • 208 citations

RelA/p65 is a molecular target for the immunosuppressive action of protein kinase A.

1995 • 198 citations

In Vivo Stimulation of IκB Phosphorylation Is Not Sufficient To Activate NF-κB

1995 • 164 citations

IKK-i and TBK-1 are Enzymatically Distinct from the Homologous Enzyme IKK-2

2002 • 138 citations

IκB Family Members Function by Different Mechanisms

2001 • 124 citations

Effect of proteasome inhibitors on monocytic IκB-α and -β depletion, NF-κB activation, and cytokine production

1998 • 64 citations

Characterization of the Recombinant IKK1/IKK2 Heterodimer

2000 • 62 citations

Nuclear factor κB (NF-κB) pathway as a therapeutic target in rheumatoid arthritis

1999 • 54 citations

IκB kinase-α and -β genes are coexpressed in adult and embryonic tissues but localized to different human chromosomes

1998 • 20 citations